基于模糊PI控制的超声波换能器谐振频率跟踪系统仿真

对于超声波换能器谐振系统,利用传统谐振频率跟踪方法动态性能不甚理想,故而采用模糊控制与PI控制相结合的模糊PI控制方法.首先对超声波发生器系统进行建模,再由模糊规则表、模糊化、反模糊化以及在线仿真整定,确定PI控制器参数,最后以相位差作为模糊PI控制器的输入量,进而得到新的驱动频率控制量,新的驱动频率信号驱动逆变器得到换能器此时所需要的控制频率,即换能器谐振频率.计算机仿真结果表明,模糊PI控制方法使整个系统具有更好的动态和静态性能,能有效地使换能器工作在谐振频率.     

Improvement in the protective performance and adhesion of polypyrrole coating on AZ31 Mg alloys

The electrochemical synthesis of polypyrrole (Ppy) coating on AZ31 magnesium alloy was successfully achieved in a solution containing sodium salicylate and monomer of pyrrole through cyclic voltammetry technique. The effect of potential range, passivation pretreatment and number of cycles of polymerization on the quality and protective performance of the coatings was evaluated using surface analysis and electrochemical techniques. Through taking the advantage of charge transfer resistance, current density, corrosion potential, optical microscopy images and SEM micrographs, the optimum condition of synthesis of a Ppy coating with the best adhesion and corrosion protection was determined. The optimal PPy coating synthesized over AZ31 increases the polarization resistance and decreases the corrosion current more than one order of magnitude and shift the corrosion potential about 200 mV toward nobler potentials. The SEM studies showed that Ppy coating have cauliflower morphology of Ppy grains with a diameter ranging from 20 nm to 60 nm.     

Metformin targets liver tumor-initiating cells through the PI3K/Akt/mTOR survival pathway

Liver tumor-initiating cells （T-ICs） are thought to be inherently resistant to the cytotoxic effects of chemo- therapy, and can self-renewal and maintain tumor-initiating potential. Therefore, effective anticancer research strategies should target the unique properties of T-ICs. In this study, we found that metformin, a first-line drug of choice for the treatment of type 2 diabetes, inhibited liver T-ICs both in vivo and in vitro. Metformin inhibited the formation of hepato- spheres and epithelial-specific antigen-positive （ESA, CD133＋） cell colonies by hepatocellular carcinoma （HCC） cell lines. Metformin also downregulated the expression of several T-IC-related genes which are involved in the signal- ing pathways, governing the self-renewal, proliferation and differentiation of T-ICs. Furthermore, the targeting of liver T-ICs by metformin was PI-3-kinase-Akt-mTOR （PI3K/Akt/ mTOR）-pathway dependent. The PI3K/Akt/mTOR inhibitorLY294002 and rapamycin abolished the inhibitory effect of metformin on CD133＋ cells, and the PI3K/Akt/mTOR stimulator EGF promoted the inhibitory effect of mefformin on CD 133＋ cells. Metformin also dramatically decreased the tumor volume and number of CD133 expressing tumor cells in a xenograft mouse model. Mefformin exerted a synergistic effect with cisplatin to target both T-ICs and non-T-ICs, and resulted in the smallest tumor volume and lowest number of CD133 expressing tumor cells. This study indicates that the antidiabetic drug metformin could potentially be used in combination therapy with chemotherapeutic agents to improve the treatment of liver cancer.     

单区域系统积差调频的改进与仿真

就单区域系统对积差调频方法进行了分析和改造,并用MALAB对其进行了仿真,仿真结果表明：改进后的比例-积差调频动态性能和稳定性有明显的提高.     

二氯磷酰胆碱的合成及分析方法研究

目的 合成可用于生物材料表面改性的活性中间体二氯磷酰胆碱.方法 由三氯氧磷和氯化胆碱在无水条件下用非均相一步法合成二氯磷酰胆碱,并对合成条件进行了探讨,对产物进行了表征和含量测定.结果 产物结构由31P NMR和IR得到证明,产物含量用改进的电位滴定法进行了测定.在最佳反应条件下,收率可以达到100%,目标产物含量可达91%.结论 非均相一步合成二氯磷酰胆碱的方法 可行,改进的电位滴定法适用于磷酸酯/盐混合体系的组分分析.对于提高目标产物的产率及改进合成条件均有指导意义.     

PI型扩展预测自适应控制器及其在造纸过程中的应用研究

建立了一种具有比例积分结构的扩展预测自适应控制器，并在造纸过程中的湿基准与纸浆流量的数学模型中进行了应用仿真研究，仿真结果显示了这种控制器良好的控制效果。     

关于PI证明的若干注记

PI证明是归结证明的一种重要类型,但是在目前所见到的文献中,对PI推理的定义还有一些不妥之处,没有确保PI推理中的每一步归结都是PI归结.文中给出了新的PI推理的定义,弥补了这一缺陷,并对PI归结的完备性定理证明所需的引理给出了两种简化证明.     

A Dynamic Model of Sensibility Analysis in Project Evaluation

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