Sequence similarity analysis of non-self CTL epitopes and mouse proteins using sequence alignment

This research analyzed amino acid sequence similarity between non-self T cell epitopes recognized by mouse antibodies and mouse proteins. Using sequence alignment,we found that only 8 of 1 108 epitopes are highly similar to mouse protein sequences. The result shows that non-self T cell epitopes are not similar or have little similarity to mouse protein sequences. Furthermore,reviewing the related literature,we also found that the eight epitopes would trigger immune responses in some particular environment,which are ignored by T cells in normal condition. The result suggests that no or low-similarity peptide vaccines can reduce the chance of collateral cross-reactions and enhance the antigen-specific immune response to vaccine.     

Photocatalytic activity of TiO<Subscript>2</Subscript> sensitized by CdS quantum dots under visible-light irradiation

In this paper, CdS quantum dots sensitized TiO2 composite powders (QD-CdS/TiO2) were synthesized by impregnating TiO2 powder into CdS sol with different concentrations. X-ray diffraction pattern (XRD) shows the crystal structures of CdS and TiO2 are cubic phase and anatase phase separately in QD- CdS/TiO2 powder samples; the crystal size of CdS in QD- CdS/TiO2 is about 3-7 nm, while TiO2 crystal size is about 20 nm. With increasing CdS content in QD-CdS/TiO2 composite, the UV-Vis absorption spectrum shifted to the longer wavelength lines, exhibiting obvious quantum size effect. The fluorescence intensity of QD-CdS/TiO2 irradiated by blue light is weaker than that of pure CdS. When the molar ratio of CdS and TiO2 is about 1∶2, the QD-CdS/TiO2 powder has the best catalytic properties under visible-light irradiation, and the degradation rate of rhodamine B (RhB) is up to 92.2% within 60 min.     

关于G/G/1排队模型中排队长度的积分

考虑了一个具有中度正则变化服务时间的G/G/1模型.假设Q(t)是排队长度,则在忙期[0,l]上,Q(t)下方所扫过的面积也具有中度正则变化的性质.     

Colpitts电路中的双涡卷混沌寄生振荡分析

通过在Colpitts振荡器中引入二次反馈项,观察到了新奇的双涡卷吸引子.这个具有反馈项的混沌系统具有3个平衡点,产生不同于Lorenz和Colpitts系统的复杂吸引子.对系统的一些基本特性,如平衡点、稳定性、Lyapunov指数谱、分岔图、相轨与庞加莱截面等进行了详细的分析.     

M2M大型装备远程监控

M2M产生于20世纪90年代中后期,以监控设备和资产为目标而产生.随着社会的不断发展和技术的不断进步,M2M不再是简单的数据在机器间的传输,更重要的是,它是机器与机器间智能化、交互式的通信.利用M2M网络实现大型装备的远程实时监控.对于企业和国家都越发重要.     

一类二阶微分方程的无穷周期解

通过临界点理论和Z2不变群指标理论,证得I(x)有无穷多个临界点,再由变分原理可得方程(2)与方程(3)等价,在改变条件的情况下,得出了一在二阶泛函微分方程存在无穷多个周期解.     

论战时国民政府开发西部取得的成效及其不足

抗战爆发后，随着东南的沦陷，国都的西迁，大后方的地位日见重要。为了抗战建国，国民政府先后制定了一系列发展大后方的政策，诸如扶持建立工业、发展农业、兴办水利、开发交通等。在国家政权力量的介入以及人民的支持下，这些政策的实施取得了一定的效果，使西部社会的各个层面发生了一定的变动，不仅初步改变了西部贫穷落后的面貌，而且有力地支援了抗战。但是由于抗战特殊时期，国民政府无力投巨资于西部的开发；同时由于西部各地方实力派的掣肘，使许多开发措施很难真正付诸实施；加之国民政府自身的短视，对开发西部抱以功利主义的态度，使得开发政策总是因人因时而变，没有长久性和系统性。其开发成果也相应受到了影响。     

Plasmonic biosensors and nanoprobes based on gold nanoshells

Gold nanoshells (GNSs), consisting of a dielectric core coated with gold, have gained extensive attention as they show readily tunable optical properties and good biocompatibility. As highly sensitive and label-free optical biosensors with wide applications, GNSs have been investigated in many fields including drug delivery, immunoassay, cancer treatment, biological sensing and imaging. Taking advantage of the adjustability of the local surface plasmon resonance (LSPR) and the sensitivity of the surfaceenhanced Raman scattering (SERS) signal of GNSs, we have developed diverse applications including plasmonic biosensors and nanoprobes based on GNSs. In this review we introduce plasmonic and electromagnetic properties and fabrication methods of GNSs. We describe research progress in recent years, and highlight several applications of GNSs developed by our group. Finally we provide a brief assessment of future development of GNSs as plasmonic materials that can be integrated with complementary analytical techniques.     

单-6-叠氮-β-环糊精与苯乙炔的点击化反应

利用CuI/NBS这种新型催化体系来促进单-6-叠氮-β-环糊精与苯乙炔之间的偶联反应,通过这个多组分反应可以高效地以炔和叠氮为原料一锅法制备5-碘代-1,4-取代-1,2,3-三氮唑类化合物.