The development and function of regulatory T cells

Regulatory T cells (Tregs) are a critical subset of T cells that mediate peripheral tolerance. There are two types of Tregs: natural Tregs, which develop in the thymus, and induced Tregs, which are derived from naive CD4⁺ T cells in the periphery. Tregs utilize a variety of mechanisms to suppress the immune response. While Tregs are critical for the peripheral maintenance of potential autoreactive T cells, they can also be detrimental by preventing effective anti-tumor responses and sterilizing immunity against pathogens. In this review, we will discuss the development of natural and induced Tregs as well as the role of Tregs in a variety of disease settings and the mechanisms they utilize for suppression. C. J. Workman, A. L. Szymczak-Workman, L. W. Collison, and M. R. Pillai contributed equally.     

卟啉铊及其氰基配合物的205Tl NMR的溶液表征

在有机溶剂中 ,合成制备了新的单核卟啉铊和卟啉铊氰基配合物 ([(tpp) Tl(O2 CCF3) ]和 [(tpp) Tl(CN) ])。通过使用 1 3C富集的 1 3CN配体 2 0 5Tl核磁共振的研究 ,两个配合物的组成都得以清楚的表征 ,表明 2 0 5Tl核磁共振谱是确定溶液中铊配合物组成的一种有效方法     

极小T3LF拓扑空间

对任意完全分配格Ｌ和非空集Ｘ,本文证明了Ｌ＾Ｘ上极小Ｔ３ＬＦ余拓扑的存在性以及这种余拓扑的特征定理,并给出了构造Ｌ＾Ｘ上比给定的非极小Ｔ３ＬＦ余拓扑δ严格弱的Ｔ３ＬＦ余拓扑的一种方法。     

中科院与浙江省科技合作模式研究

院地合作是中国科学院参与区域创新体系建设的重要途径,也是中科院面向国民经济主战场推动科技成果转移转化的重要方式。随着院地合作内涵的不断深化和拓展,合作模式呈现出多层次、多主体、多类型等新特征,但也逐渐暴露出一些问题。文章以组织行为理论相关研究为基础,构建了参与主体、动力机制、发挥作用、服务形式四维分析框架,基于该分析框架,凝练提出了中科院与浙江省科技合作的融合模式、平台模式和精准服务模式,同时发现资源整合力度不够、长效运行机制缺乏、企业创新能力不足等问题制约着二者的科技合作成效。基于上述分析,进一步为深化院地合作提出了相关政策建议。     

相变存储器的高可靠性多值存储设计

基于相变存储器(PCM)已有的2T2R结构,提出一种以比值为导向的状态定义方法,以实现2T2R结构下PCM的多值存储.它在相变电阻具有4态可编写的能力下,可以实现单元内8态存储,同时对小尺寸验证,而对PCM存储电路的优化将使得PCM更具竞争力.同样基于这种以比值为导向的状态定义,一种软硬件相结合的新型纠错码方法使得对全部数据位的错误监测成为可能.     

Polyisoprenyl glycolipids as targets of CD1-mediated T cell responses

T cells are well known to recognize peptide antigens presented by major histocompatibility (MHC) class I or class II molecules. More recently, the CD1 family of antigen-presenting molecules has been shown to present both mammalian and microbial glycolipid antigens for specific recognition by T cells. Human CD1c proteins mediate T cell recognition of polyisoprenyl glycolipids, evolutionarily conserved phosphoglycolipids, which function in glycan synthesis pathways. This family of antigenic molecules is particularly attractive for the study of the molecular features that control T cell recognition of self and foreign glycolipids because natural polyisoprenols from mammals, fungi, protozoa, mycobacteria and eubacteria differ in structure. Moreover, these naturally occurring structural differences can influence their recognition by CD1c-restricted T cells. This review of the structural diversity and evolutionary relationships of polyisoprenoid glycolipids emphasizes those features of polyisoprenyl glycolipid biosynthesis that are relevant to their functions as targets of CD1-mediated T cell responses. Received 16 March 2001; received after revision 19 April 2001; accepted 23 April 2001     

广义逆A(2)T,S的体积

研究了广义逆A（T,S）^（2）是的体积,在不必首先计算出广义逆A（T,S）^（2）的前提下,导出了广义逆A（T,S）^（2）的体积表示,推广了文献[3]中的结果．由此分别给出了A的加权Moore-Penrose逆,Drazin逆Ad及群逆Ag的体积表示式．     

一类工业过程的神经元智能控制

研究了基于自适应神经元的一类工业过程控制问题，分析了闭环系统稳定性与神经元控制器参数的关系，给出了闭环系统稳定的充分条件及神经元学习参数初值的一种方法及学习的收敛性证明。理论分析表明，神经元智能过程控制系统有很强的鲁棒性和适应性，仿真结果表明了其优良的性能。     

HLA-A*0201限制性CTL表位肽的分子力场分析

运用比较分子力场(CoMFA)和比较相似性指数分析(CoMSIA)方法研究了50个HLA-A* 0201限制性CTL表位九肽结构与亲和性间的关系,另外15个表位九肽作为预测集用于检验模型的预测能力。结果表明,采用CoMSIA得到的构效关系模型(q2 =0.608,r2 =0.987,F=440.4,SD=0. 111)要明显优于采用CoMFA得到的构效关系模型。在CoMSIA计算中,当引入疏水场时,三维构效关系模型得到明显改善,通过该三维构效关系模型,可较精确地估算预测集中15个CTL表位肽与HLA-A* 0201间的亲和力(r2pred=0. 703,SD=0. 368)。通过分析分子场等势面图在空间的分布,可以观察到表位肽分子周围的立体及疏水特征对表位肽与HLA-A* 0201间结合亲和力的影响,从而为进一步对CTL表位肽进行结构改造并基于此进行治疗性疫苗分子设计提供理论基础。