领域本体信息源选取方法研究与实现

构造领域本体所需的信息源选取方法的研究对解决本体的构造质量、构造效率等问题,以及推广与发展领域本体有着重要意义.传统的信息源文档选取方法只考虑概念因素,不能很好地解决该问题.因此,首先利用抽象方法分析了领域本体所需信息源具有的概念性、关系性和预测性等特点.然后,针对这些特点分别采用改进的VSM方法、基于本体关系距离的方法以及神经网络方法计算文档权值.最后,通过编写的软件OnMaker产生模拟数据得到概念、关系和预测3个权值,从而计算出每个文档权值,并使用与"湿地保护"相关的真实文档验证该模型,达到了较好排序选取的效果.     

基于深腾1800机群系统的分子动力学并行仿真研究

介绍了分子动力学并行仿真计算的软硬件环境,分析了现有的几种并行算法,确定采用区域分解法作为并行算法,并在此基础上提出了基于区域二次划分的分子动力学并行仿真算法.另外,阐述了原子链、原子近邻表和原子亲属表的概念,提出了基于永久序号的消息传递策略.最后,设计了分子动力学并行仿真程序,并分别在1、2、3、4台结点机上进行了实验,运行结果表明:加速比随着结点数的增加而增加,并行效率虽略有下降但都在87.5%以上,并行效率并没有随着结点数的增加有明显的降低,说明并行程序具有很好的扩展性.     

一种快速高效二维时域有限元束传播法

提出并建立了一种新型的快速分析平面光波光路器件传输特性的2D时域有限元束传播法(FE-TD-BPM)模型.与常规时域差分格式的有限元束传播法相比,在时域实现了一维有限元(FEM)离散化处理,基于完全匹配层(PML)边界条件给出了全有限元离散化模型.为了验证算法的精度以及速度,模拟分析了直脊波导以及波导光栅,并且与已有文献的计算结果进行比较,结果表明,该算法无条件稳定、计算速度快,与常规时域差分格式的有限元束传播法相差在0.002%以内,并节省了约70%的机时.     

Kaplansky变换在高阶上的推广

给出了高阶Kaplansky变换的定义,并且刻画了高阶Kaplansky变换的基本性质.同时,对v-凝聚整环上的高阶Kaplansky变换进行了系统的研究,证明了若R是v-凝聚整环(分别地,Mori整环),则Ω(s)也是v-凝聚整环(分别地,Mori整环).     

热传导方程的一类区域分解差分算法

把求解区域分成若干个子域,在不同子域中采用不同的计算步长,对方程的紧差分格式在特殊情形下采用区域分解法,并给出相应的先验误差估计式。     

图书馆与大学生知识领域拓宽能力的培养

阐述了大学生知识领域拓宽的必要性,探讨了图书馆在大学生知识领域拓宽中的作用,提出了高校图书馆促进大学生知识领域拓宽的措施.     

单片机总线上多时钟域下数据传递的可靠性研究

对单片机总线上多时钟域下数据传递的可靠性进行研究，阐述了使用寄存器锁存电路、多级锁存电路2种方法解决多时钟域下数据传递可靠性时存在的问题，提出了采用4级锁存并判断跳变沿的方式能确保多时钟域下数据可靠传递的方法，具有很高的应用价值．     

系数优化在改善时间步进算法稳定性中的应用

隐式时间步进算法在求解二维物体的散射时,随着时间的推移,也会出现后时不稳定性的问题.文章在先五步后三步平均公式的基础上利用误差公式对系数进行筛选,改善了原公式在隐式时间步进算法中计算二维物体时产生的后时震荡情况；采用基于时域电场积分方程的隐式时间步进算法,分别计算了TM高斯脉冲入射到无限长导体圆柱和导体方柱时的导体表面...     

Prediction of sites under adaptive evolution in flavin-containing monooxygenases: Selection pattern revisited

Flavin-containing monooxygenase (FMO), like cytochrome P450 (CYP), is a monooxygenase that uses the reducing equivalents of NADPH to reduce one atom of molecular oxygen to water, while the other atom is used to oxidize the substrate. Recently, it was shown that some CYP isoforms have been subject to positive selection. However, it is unknown whether the highly conserved phase I detoxification enzyme, FMO, has undergone similar positive Darwinian selection. We used maximum-likelihood models of codon substitution, evolutionary fingerprinting, and cross species comparison to investigate the occurrence of adaptive evolution in FMO sequences. We used recent genomic data from a range of species, including vertebrates and invertebrates. We present the evidence for the occurrence of adaptive evolution in mammalian FMO 3, 4, 5, and fugu FMOs but not in mammalian FMO 1, FMO 2, frog FMOs, other fish FMOs and invertebrate FMOs. The sites under adaptive evolution were significantly associated with the insertion domain in mammalian FMO 5. We identified specific amino acid sites in FMOs 3–5 that are likely targets for selection based on the patterns of parallel amino acid change. The most likely role of adaptive evolution is the repair of mutations that permitted optimal NADP+ binding and improved catalytic efficiency. The occurrence of positive selection during the evolution of phase I detoxification enzymes such as FMOs 3–5 and fugu FMO suggests the occurrence of both high selection pressure acting on species within their unique habitats and significant changes in intensity and direction (forms of xenobiotics and drugs) resulting from changes in microhabitat and food.     

Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors

The Alzheimer’s amyloid precursor protein (APP) belongs to a conserved gene family that also includes the mammalian APLP1 and APLP2, the Drosophila APPL, and the C. elegans APL-1. The biological function of APP is still not fully clear. However, it is known that the APP family proteins have redundant and partly overlapping functions, which demonstrates the importance of studying all APP family members to gain a more complete picture. When APP was first cloned, it was speculated that it could function as a receptor. This theory has been further substantiated by studies showing that APP and its homologues bind both extracellular ligands and intracellular adaptor proteins. The APP family proteins undergo regulated intramembrane proteolysis (RIP), generating secreted and cytoplasmic fragments that have been ascribed different functions. In this review, we will discuss the APP family with focus on biological functions, binding partners, and regulated processing.