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排序方式: 共有74条查询结果,搜索用时 109 毫秒
41.
探讨加用气流阻力负荷(FRL) 状态下流速容量(FV) 曲线检查对初检OSA 患者的意义对象为24 名健康成年男性及21 例男性阻塞性睡眠呼吸暂停(OSA) 患者经整夜多导睡眠仪检查诊断或排除OSA模拟实验结果发现只有同时加上可陷闭管及FRL 时,才出现显著吸气气流受限无FRL时,FV 曲线( 以FEF50/FIF50 比值大于1 为指标) 检查发现OSA的敏感性和特异性分别为33 .3 % 和91 .6 % ,阳性预测率为63 .6 % 加用FRL 时敏感性为76 .2 % ,特异性为75 % ,阳性预测率为72 .2 % 吸、呼气相峰值流速比值及中期峰值流速比值与OSA 严重呈显著相关联合应用加FRL及常规FL曲线检查可能对OSA 患者初筛有较高价值 相似文献
42.
Stenberg D 《Cellular and molecular life sciences : CMLS》2007,64(10):1187-1204
Sleep is regulated by homeostatic and circadian factors, and the regulation of sleep of mammals shares many molecular properties
with the rest state of submammalian species. Several brain structures take part in waking: the basal forebrain, posterior
and lateral hypothalamus, and nuclei in the tegmentum and pons. Active sleep mechanisms are located to the preoptic/anterior
hypothalamic area. In addition to acetylcholine and monoamines, glutamate and hypocretin/orexin are important waking factors.
Gamma-aminobutyric acid and several peptide factors, including cytokines, growth hormone-releasing hormone and prolactin,
are related to sleep promotion. Adenosine is an important homeostatic sleep factor acting in basal forebrain and preoptic
areas through A1 and A2A receptors. Prolonged waking activates inducible nitric oxide synthase in the basal forebrain, which
through energy depletion causes adenosine release and recovery sleep. Numerous genes have been found differentially displayed
in waking compared with sleep, and they relate to neural transmission, synaptic plasticity, energy metabolism and stress protection.
The genetic background of a few sleep disorders has been solved. 相似文献
43.
目的研究两种不同的方法构建皮质发育障碍(DCDs)动物模型中的共同差异表达基因,为进一步研究DCDs形成机制提供基因水平筛选的研究平台。方法用两种方法制备DCDs模型:①射线损伤模型(射线组):采用剂量为1.45 Gy的γ射线照射妊娠15 d的SD大鼠制作子代大鼠DCDs模型;②卡莫司汀(BCNU)药物损伤模型(药物组):妊娠15 d的SD大鼠,腹腔注射BCNU制作子代大鼠DCDs模型。同时设正常对照组。对两种DCDs模型的子代新生鼠(P0)全脑做基因芯片扫描,结果与正常对照组比较,获得两种模型共有的差异基因。结果射线组大鼠与正常比较得到170个差异基因,其中25个上调,145个下调;药物组大鼠与正常比较得到259个差异基因,其中67个上调,192个下调。两组重合的基因共54个,其中3个上调,51个下调。结论皮质发育障碍是一个复杂的病理过程,本实验运用基因芯片技术,对两种不同方法构建的DCDs模型进行了研究,获得两种DCDs模型共有的基因差异表达谱,为进一步研究DCDs形成机制提供了分子生物学平台。 相似文献
44.
45.
关于大学生睡眠状况的调查分析 总被引:2,自引:0,他引:2
本研究采用睡眠状况自评量表,对371名大学生的睡眠状况进行了测量。研究结果表明:⑴有1/2的大学生存在不同程度的睡眠障碍。⑵大学生的睡眠障碍主要是“失眠反应”、“睡眠不足”、“觉醒不足”、“恶梦夜惊”、“睡眠质量差”。⑶相对于低年级的学生,高年级学生的睡眠障碍更加严重。⑷相对于不考研的学生,考研学生的睡眠时间更少,睡眠的质量也更差。 相似文献
46.
老年人肺心病多器官衰竭84例分析 总被引:1,自引:0,他引:1
分析84例老年人肺心病呼吸衰竭患者并发多器官衰竭、累及器官数目与病死率是正相关关系,累及2—5个器官死亡率分别为34.3%、65.4%、86.7%、100%,其中并发肺性脑病最多,但病死率较低。而肾功能进行性加重预后不佳。揭示老年肺心病患者病程较长,各器官功能减退、免疫功能低下,是导致肺心病多器官衰竭的重要死亡原因。 相似文献
47.
Igor P. Pogribny Frederick A. Beland 《Cellular and molecular life sciences : CMLS》2009,66(14):2249-2261
The pathogenesis of any given human disease is a complex multifactorial process characterized by many biologically significant
and interdependent alterations. One of these changes, specific to a wide range of human pathologies, is DNA hypomethylation.
DNA hypomethylation signifies one of the major DNA methylation states that refers to a relative decrease from the “normal”
methylation level. It is clear that disease by itself can induce hypomethylation of DNA; however, a decrease in DNA methylation
can also have an impact on the predisposition to pathological states and disease development. This review presents evidence
suggesting the involvement of DNA hypomethylation in the pathogenesis of several major human pathologies, including cancer,
atherosclerosis, Alzheimer’s disease, and psychiatric disorders.
The views expressed in this paper do not necessarily represent those of the US Food and Drug Administration. 相似文献
48.
阻塞性睡眠呼吸暂停患者的上气道狭窄与头姿变化 总被引:7,自引:2,他引:5
探讨阻塞性睡眠呼吸暂停(Obstructivesleepapnea,OSA)患者上气道狭窄的程度、头姿改变情况,以及这些形态学指标与病理生理学参数之间的关系。研究对象为86例男性OSA患者及37名健康男性。经整夜多导睡眠仪检查诊断或排除OSA;采用数字化技术摄取受试者头颅侧位片,并用NIHImage软件测定上气道口径、面积及头姿指标共15项。OSA患者各水平上气道前后径均显著小于对照组;经年龄及身高体重指数校正后,上述结果不变。重症OSA患者呈显著头颅前倾。头姿变化指标与呼吸暂停指数及多个水平的气道前后径呈显著相关。亚洲人种OSA患者存在明显及广泛的上气道狭窄;随OSA程度加重及上气道阻塞程度加重,患者可能出现代偿性头姿改变 相似文献
49.
The endophenotype concept was initially proposed to enhance the power of genetic studies of complex disorders. It is closely related to the genetic component in a liability-threshold model; a perfect endophenotype should have a correlation of 1 with the genetic component of the liability to disease. In reality, a putative endophenotype is unlikely to be a perfect representation of the genetic component of disease liability. The magnitude of the correlation between a putative endophenotype and the genetic co... 相似文献
50.
C. Franzini T. Cianci P. Lenzi J. P. Libert J. A. Horne P. L. Parmeggiani 《Cellular and molecular life sciences : CMLS》1986,42(6):604-606
Summary In young rabbits the slope of the temperature in the deep cervical region close to brown adipose tissue increased during desynchronized sleep at low ambient temperature. No increase occurred at neutral ambient temperature. In control rabbits (after disappearance of brown adipose tissue), the slope of deep cervical temperature did not increase during desynchronized sleep at low or neutral ambient temperatures.Preliminary data were reported at the Association des Physiologistes, Réunion de Poitiers, 20–23 June 1983.Acknowledgments. We wish to thank Giuseppe Mancinelli and Leonida Sabattini for technical assistance. This work was supported by a grant from the Consiglio Nazionale delle Ricerche, Rome. J.P.L. wishes to thank NATO for partial financial support during his stay at the Physiology Department in Bologna. 相似文献