GM(1,N)模型的离散化结构解

针对灰色系统GM(1,N)模型是以差分方程为基础进行参数估计的,而其时间响应函数却是由微分方程的解得到的。从差分方程到微分方程的跨越,缺乏充分的科学基础和理论依据。通过对灰色系统模型建模机理进行深入剖析,利用采样定理和状态转移矩阵在差分方程和微分方程之间架起一座桥梁,通过算例仿真实验证明了该算法的有效性。     

信噪比的估计及其在参数设计中的作用

本文对SN比的估计进行了探讨,给出了另外两个估计公式——极大似然估计、一致最小方差无偏估计。文末以气动换向装置的参数设计为实例,用这两种不同的方法进行设计,所得结论基本上是一致的。     

不分明单位区间及其在不分明拓扑中的应用

不分明单位区间是一个十分重要的不分明拓扑空间,在不分明拓扑中有着广泛的应用.国内外学者已发表了不少文章讨论它的各种性质和应用。本文综述了有关这方面的某些主要研究成果.     

黄体酮对离体大鼠胸主动脉条收缩反应的影响

黄体酮（Pro)可使KC1（60mmol/L)或NE（1umol/L)诱发的肌条收缩明显松弛，IC50分别为70.3和93.9(umol/L)；而戊脉安（Ver)的IC50则分别为0.085和0.766(umol/L).Pro和Ver均可使NE或CaCl2引起的肌条收缩量效曲线右移，最大效应降低，呈非竞争性拮抗；Pro的PD2分别为4.072和4.688,Ver的PD2为5.563和6.456。无钙液中加入NE1umol/L引起肌条收缩（1相），再加入CaCl22.5mmol/L引起再次收缩（2相）；Pro可显著抑制上述两种收缩，而Ver仅对2相收缩有显著抑制作用，以上结果表明4；黄体酮有直接扩张血管作用，它与钙拮抗剂戊脉安相似，对电压依赖性钙通道及受体调控性钙通道均有阻滞作用；此外，它还能抑制NE激活的细胞内钙的释放。     

Induction of chromosomal aberrations by the anthracycline antitumor antibiotics N,N-dimethyldaunomycin and aclacinomycin A

Summary The clastogenic effect of the anthracycline antitumor antibiotics, N,N-dimethyldaunomycin and aclacinomycin A, was studied in a murine hemopoietic cell line (Friend leukemia cells). A dose-dependent increase in chromatid lesions, i.e., achromatic lesions, chromatid breaks, chromatid deletions and triradial or quadriradial chromosomal exchange figures, was found. It appears that the clastogenicity of N,N-dimethyldaunomycin and aclacinomycin A is lower than that of the classic anthracycline, daunomycin, which is also a potent mutagen and carcinogen. The data demonstrate that the capacity of chemicals to induce point mutations and chromosomal aberrations may not necessarily be correlated: aclacinomycin A is devoid of mutagenic activity in bacterial (Salmonella typh.) and mammalian cell (HGPRT) mutagenesis assays, and is non-carcinogenic in rats. Nevertheless, it was now found to possess clastogenic activity.     

N,N-二甲氨基-1,3-二氯丙烷的合成

本文报导了用1,2,3-三氯丙烷与二甲胺为原料,在40℃、有相转移催化剂和碱存在下,合成N,N-二甲氨基-1,3-二氯丙烷新方法。反应4小时完成,其产率为15～20%。此外,还讨论了相转移倦化剂在N-烷基化和消除反应中的作用。     

ATM网络中突发业务处理模型

根据不同业务特性设立四种优先级进行管理，采用轮询方式进行各优先级队列信元的发送处理。设计了ＡＴＭ网络中突发业务处理模型。用Ｍ／Ｍ／１／Ｎ数学模型对突发业务的信元丢失情况进行分析。该模型使突发业务得以公平传输，同时确保服务质量并适用于ＡＴＭ网络节点的信息处理。     

大学新生心理健康状况的调查分析

使用SCL－90评定长沙大学2001级新生的心理健康状况。结果显示，有10．9％的新生存着各种明显的心理健康问题。男女学生、本专科学生之间心理健康水平存在显著差异。     

Multitasking with neurotensin in the central nervous system

The 13-amino acid peptide neurotensin (NT) was discovered over 30 years ago and has been implicated in a wide variety of neurotransmitter and endocrine functions. This review focuses on four areas where there has been substantial recent progress in understanding NT signaling and several functions of the endogenous peptide. The first area concerns the functional activation of the high-affinity NT receptor, NTR-1, including the delineation of the NT binding pocket and receptor domains involved in functional coupling to intracellular signaling pathways. The development of NT receptor antagonists and the application of genetic and molecular genetic approaches have accelerated progress in understanding NT function in several areas, including the involvement of NT in antipsychotic drug actions, psychostimulant sensitization and the modulation of pain, and these are reviewed in that order. There is now substantial evidence indicating that NT is required for certain antipsychotic drug actions and that the peptide plays a key role in stress-induced analgesia.Received 18 March 2005; received after revision 9 May 2005; accepted 23 May 2005