汽－液相变中成核的热力学理论

对现有汽－液相变过程有关文献中关于汽泡形成过程的分析提出了不同看法，并利用热力学理论从亚稳平衡态的特性出发对汽泡形成的热力学机制作出了分析，对系统从液态转变到汽－液共存状态的各阶段作出了说明。     

土坡稳定分析变分法的应用

本文应用土压力变分法理论解决土坡滑裂面型式及稳定安全系数 K 等问题,并可减少试算工作量.该法证明曲线及折线滑裂面是统一的,在一定条件下能相互转化.通过算例初步表明所得结果是可取的.     

时变线性系统的稳定性

本文研究了一般时变线性系统的渐近稳定性。利用构造二次型李雅普诺夫函数的思想,引进一个新的讨论时变线性系统稳定性的方法,得到了较宽和较实用的结果.     

水分对头孢唑林钠药效的影响初探

用平衡湿度法测定了头孢唑林钠的临界相对湿度，在２０℃时约为６７％。同时，通过破坏性实验考察了水分对其药效的影响，初步结果表明，水分每增加１％，效价降低约０．５％。据此，提出了分装操作的若干注意事项。     

多重特征值处分岐解的稳定性

本文讨论形如这类运动方程的平衡态分歧解(即M(x,λ)=0的分歧解)的线性化稳定性问题。本文采用一个算子的K谱概念,考察广义的算子演算,推广了线性泛函中的预解式,进而推广泛函分析中关于谱摄动的某些结果,在半单特征值以及K在KN(L(0))上存在广义逆和由M(x,λ)=0导出的分歧方程为F(u,λ)=0的条件假设下,得到关于平衡态分歧解的线性化稳定性可由关于平衡态分歧解的线性化稳定性确定的结论,将Sattinger,D.H.的结果作为定理3.9当K=I时的特例。     

Elucidation of the relationship between enzyme activity and internal motion using a lysozyme stabilized by cavity-filling mutations

We investigated the activity and the internal motions of a stabilized mutant hen lysozyme (HEL) in which the residues M12 and L56 were mutated to L and F, respectively (LF mutant HEL). The result of the activity measurements against glycol chitin at various temperatures suggested that the temperature dependence of the activity of LF mutant HEL shifted to the high-temperature side compared with that of wild-type HEL. The detailed internal motions of LF mutant HEL in the absence and presence of a substrate analogue, (NAG)₃, were examined by model-free analysis at 35°C. The results showed that the internal motions of LF mutant HEL in the presence of (NAG)₃ were drastically restricted compared with those in wild-type HEL. Our findings thus suggested that the mutation to the stabilized lysozyme restricted internal motions required for the enzymatic reaction.Received 8 February 2005; accepted 10 March 2005Y. Yoshida and T. Ohkuri contributed equally to this work.     

Structural and dynamical features contributing to thermostability in α-amylases

In recent years an increasing number of studies on thermophilic and hyperthermophilic proteins aiming to elucidate determinants of protein thermostability have yielded valuable insights about the relevant mechanisms. In particular, comparison of homologous enzymes with different thermostabilities (isolated from psychrophilic, mesophilic, thermophilic and hyperthermophilic organsims) offers a unique opportunity to determine the strategies of thermal adaptation. In this respect, the medium-sized amylolytic enzyme α-amylase is a well-established representative. Various studies on α-amylases with very different thermostabilities (melting temperature T_m = 40–110°C) report structural and dynamical features as well as thermodynamical properties which are supposed to play key roles in thermal adaptation. Here, results from selected homologous α-amylases are presented and discussed with respect to some new and recently proposed strategies to achieve thermostability.Received 28 February 2005; received after revision 29 April 2005; accepted 19 May 2005     

还原糖和无机盐对蔗糖热稳定性的影响研究

本论文主要研究还原糖和部分无机盐对熔融态和溶液态蔗糖的热稳定性影响。指出，还原糖和部分中性无机盐会降低蔗糖的热稳定性（其中果糖的影响大于葡萄糖；镁离子的影响程度在所测试的无机盐中最为显著），而强碱弱酸类无机盐会提高蔗糖的热稳定性。     

具有表面活性物质的幂律流体沿斜面流动的稳定性

本文研究了具有表面活性物质的幂律流体在重力作用下沿斜面流动的稳定性得到了临界雷诺数R_c作为幂律指数n、浓度w和平板斜率β的函数,并对其稳定性进行分析。     

巷道顶板移动变形的动态数据处理

本文从布设巷道断面动态监测网出发,应用动态平差理论,分析了动态网形的时域可靠性,并应用突变论方法分析了测点位移系统的结构稳定性,提出了分区段分析建模原则,探讨应用门限自回归建模方法,实例验证了以上方法的正确性。