脑活动的自组织特征研究

大脑的活动规律是神经科学研究的重点和难点之一，揭示脑的工作原理将有助于真正发现自我，大脑是一个高度的自组织系统，其活动有许多固有特征，相应有许多生物物理解释模型，从不同方面刻画了脑功能，建立一个自组织模型，分析表明该模型可以从神经元活动的共性上来解译脑活动的某些一般规律。     

Serotonin and 5-hydroxyindoleacetic acid concentrations in individual hypothalamic nuclei and other brain areas of rat

Summary Serotonin and 5-hydroxyindoleacetic acid (5-HIAA) were measured in individual nuclei of rat hypothalamus and other brain areas using HPLC with electrochemical detection. 5-HIAA levels were first demonstrated in hypothalamic and some discrete brain areas. The 5-HIAA/5-HT ratio was highest in the n. caudatus putamen, high in the n. ventromedialis and lowest in the n. suprachiasmaticus.     

关于形成创新方案的模式探讨

提出了在组织内部形成创新方案的模式,即组织要在内部组建创新团队,并为团队提供“安全空间”和“新空间”,使创新团队能够从技术、个人、组织等3个角度,研究并提出创新方案,然后,综合基于3个角度创新方案的优点,形成综合最佳方案。     

不同脑负荷脑电特征的近似熵表征研究

目的研究不同生理状态下的脑电特征(EEG)。方法利用一种度量时间序列复杂性的非线性统计方法——近似熵(ApEn)方法。结果近似熵能够有效地反映脑电信号的变化情况。结论近似熵是一种值得重视且很有发展前景的复杂性分析方法。     

《物权法》实施对船舶抵押权之影响研究

船舶抵押权是一项重要的物权制度,《海商法》和《担保法》已就船舶抵押权制度作了规定,而新实施的《物权法》在具体规范上有了较大的改进与突破,其在适用顺序上优于《担保法》并对《海商法》进行了补充与修正。本文就《物权法》实施后在船舶抵押权登记及效力、船舶抵押代位物的范围、船舶抵押权的实现条件及方式、船舶抵押权的诉讼时效等方面进行了阐述。     

美国人效能增强技术发展应用

美国一直在进行士兵“超级”能力方面的研究,采用多项举措推动人效能增强技术发展.从顶层战略设计、科研机构任务、经费持续投入3个方面对美国人效能增强技术发展特点进行了综合分析,概述了美国人效能增强技术在体能、技能、智能等领域研究成果与进展,并分析了美国人效能增强技术的发展趋势和可能导致的社会伦理学问题.     

论营养与智力开发的相关性

本文根据大脑营养学研究近况,论证了营养与智力开发的相关性,并分析了10种营养物质与脑的生理机能的关系.     

Occurrence of retinal and 3-hydroxyretinal in a possible photoreceptor of the silkworm brain involved in photoperiodism

Summary Deficiency of dietary carotenoid and vitamin A caused an absence of photoperiodic response of diapause induction in the silkworm,Bombyx mori, and an addition of vitamin A to the diet restored the response. By high pressure liquid chromatography (HPLC) a possible photoperiodic receptor of the silkworm brain was found to contain both retinal and 3-hydroxyretinal which are chromophores of insect visual pigments. These pieces of evidence suggest that a retinoid protein might function in the photoperiodic response of the silkworm.     

A relevant in vitro rat model for the evaluation of blood-brain barrier translocation of nanoparticles

Poly(MePEG₂₀₀₀cyanoacrylate-co-hexadecylcyanoacrylate) (PEG-PHDCA) nanoparticles have demonstrated their capacity to reach the rat central nervous system after intravenous injection. For insight into the transport of colloidal systems across the blood-brain barrier (BBB), we developed a relevant in vitro rat BBB model consisting of a coculture of rat brain endothelial cells (RBECs) and rat astrocytes. The RBECs used in our model displayed and retained structural characteristics of brain endothelial cells, such as expression of P-glycoprotein, occludin and ZO-1, and immunofluorescence studies showed the specific localization of occludin and ZO1. The high values of transendothelial electrical resistance and low permeability coefficients of marker molecules demonstrated the functionality of this model. The comparative passage of polyhexadecylcyanoacrylate and PEG-PHDCA nanoparticles through this model was investigated, showing a higher passage of PEGylated nanoparticles, presumably by endocytosis. This result was confirmed by confocal microscopy. Thanks to a good in vitro/in vivo correlation, this rat BBB model will help in understanding the mechanisms of nanoparticle translocation and in designing new types of colloidal carriers as brain delivery systems.Received 4 March 2005; accepted 14 April 2005