胰岛素信号通路PI3K／Akt对海马神经元β-淀粉样前体蛋白裂解酶1mRNA水平的影晌

目的通过胰岛素和磷脂酰肌醇-3激酶（P13K）抑制剂渥曼青霉素（wortmannin）对P13K／丝氨酸苏氨酸蛋白激酶（P13K／Akt）信号通路的激活和抑制作用,观察P13K／Akt信号通路对海马神经元β-淀粉样前体蛋白裂解酶1（BACEl）mRNA水平表达的影响。方法20只sD大鼠随机分为空白对照组、假手术组、胰岛素组和渥曼青霉素组,海马立体定向注射胰岛素和P13K抑制剂渥曼青霉素。逆转录一聚合酶链反应（RT-PCR）检测P13K／Akt信号传导下游蛋白Akt以及BACEImRNA水平。结果注射胰岛素的海马P13K信号通路下游信号分子：AktmRNA表达上调（分别较空白和阴性对照组P=0．047,P=0．002）,而BACElmRNA表达下调（分别较空白和阴性对照组P=0．004,P=0．01）。渥曼青霉素组的P13K下游信号分子AktmRNA表达明显被抑制（分别较空白和阴性对照组P=0．002,P=0．039）,同时BACEImRNA的表达较对照组上调（分别较空白和阴性对照组P=0．039,P=0．018）。结论胰岛素信号通路P13K／AM可以调节BACEl的转录水平参与阿尔茨海默病的发病机制。     

NAC1启动子驱动GFP表达的组织特征及对生长素和赤霉素的反应

将拟南芥中转录因子基因NAC1上游调控区1kb克隆到pRD420质粒，构建由NAC1启动子驱动绿色荧光蛋白基因（GFP）表达的植物表达载体，并以此载体转化烟草，对阳性转基因植株研究表明，GFP在根部有较高水平的表达.进一步用生长素、生长素拮抗剂NPA和赤霉素处理，荧光强度的变化表明：该调控区受生长素作用的同时也受赤霉素诱导.初步说明NAC1基因不仅是一个生长素反应基因，同时可能也是一个赤霉素反应基因.     

遗传算法在飞机目标识别中的应用

针对雷达目标识别中特征维数压缩和神经网络的隐含层结点数的确定等关键问题 ,提出了一种基于遗传算法的目标识别方法 ,该方法首先构造了一个符合目标识别这一特定问题的初始种群 ,然后利用遗传算法模拟生物遗传迭代和自然选择的遗传机理 ,通过多次遗传迭代最终收敛于问题的一个满意解。最后将该方法用于对三类飞机目标的分类和识别 ,验证了该方法用于目标分类和识别的可行性和有效性。     

Radau IIA方法对比例延迟微分方程的渐近稳定性

研究Raudau IIA 方法用于求解比例延迟微分方程时的渐近稳定性。近年来比例延迟微分方程数值解的性质已被数位数学家所研究,他们使用的步长都是定步长,一般情况下将推导出较难分析的递推关系,在本文中出于理论和计算两方面的原因,我们研究强制变步长计算方案,这种解法得到不变阶差分方程。我们证明了Raudau IIA 方法是渐近稳定的。     

灰色系统的分离建模方法

首先给出了平移算子和数据序列函数的定义 ,并在平移算子和数据序列函数的基础上提出了一种灰色系统的分离建模方法 .以全国电视机产量的预测为例 ,证明分离建模方法能够提高建模的精度 .这说明分离建模方法是很有意义的.     

浅谈质量与速度

本文论述了在公路建设中工程质量与速度的关系，提高了目前工程质量管理存在的弊病及进行科学管理应抓好的几个环节 。     

DISTRIBUTION OF VORTEX BARRIERS AT DIFFERENT TEMPERATURES FOR TL 2212 FILM

ＴｈｅｅｎｅｒｇｙｂａｒｒｉｅｒｏｆｖｏｒｔｅｘｍｏｔｉｏｎＵｉｓｖｅｒｙｉｍｐｏｒｔａｎｔｉｎｖｏｒｔｅｘｄｙｎａｍｉｃｓ．Ｉｎｔｈｉｓｌｅｔｔｅｒ，ＷｅｒｅｐｏｒｔｓｕｃｈｂａｒｒｉｅｒｄｉｓｔｒｉｂｕｔｉｏｎｆｕｎｃｔｉｏｎＰ（Ｕ）ｄｅｔｅｒｍｉｎｅｄｂｙａｃｓｕｓｃｅｐｔｉｂｉｌｉｔｙ（ａｃｓ）ｔｅｃｈｎｉｑｕｅ．ＴｈｅｅｆｆｅｃｔｓｏｆｆｒｅｑｕｅｎｃｙａｎｄａｃａｍｐｌｉｔｕｄｅｏｎａｃｓｗｅｒｅｍｅａｓｕｒｅｄｆｏｒａｔｈｉｎｆｉｌｍＴｌ２Ｂａ２ＣａＣｕ２Ｏ８ｉｎａｄｃｍａｇｎｅ…     

Effects of the Water in Mixed Solvent on the Epoxidation Reaction of Propylene with TS-1 Catalyst

The epoxidation reaction of propylene and hydrogen peroxide with zeolite catalyst containing titanium-silicalite (TS-1)has been studied, and the reaction in the mixed solvent of water/methanol has been discussed. It is shown that the selective of epoxidation propylene decreases while the selective of propylene glycol increases, when the water content increases in the mixed solvent of me thanol/water.     

Relationships between D1 protein, xanthophyll cycle and photodamage-resistant capacity in rice (Orysa sativa L.)

Relationships between D1 protein, xanthophyll cycle and subspecific difference of photodamage-resistant capacity have been studied in O. japonica rice varieties 02428 and 029 (photoinhibition-tolerance) and O. indica rice varieties 3037 and Palghar (photoinhibition-sensitivity) and their reciprocal cross F1 hybrids after photoinhibitory treatment. It was shown that PSⅡ photochemical efficiency (Fv /Fm) decreased, and xanthophyll cycle from violaxanthin (V), via anaxanthin (A), to zeaxanthin (Z) was enhanced and non-photochemical quenching (qN) increased accordingly in SM-pretreated leaves of rice when the synthesis of D1 protein was inhibited, and that there was a decrease in qN and, as a result, more loss of D1 protein and a big decrease in Fv /Fm in DTT-pretreated leaves when xanthophyll cycle was inhibited. O. japonica subspecies had a higher maintaining capacity of D1 protein and a decrease of Fv /Fm in a more narrow range, and exhibited more resistance against photodamage, as compared with O. indica subspecies. The above physiological indexes in reciprocal cross F1 hybrids, though between the values of their parents, were closer to maternal lines than to paternal lines. Experimental results support the concept that the turnover capacity for D1 protein is an important physiological basis of photoinhibition-tolerance, and will provide the physiological basis for selection of the photoinhibition-tolerant parents and develop a new approach to breed hybrids with high photosynthetic efficiency.     

离心式分子蒸馏设备计算机控制系统

介绍自行研制的离心式分子蒸馏设备（ＬＦＺ－１）的计算机控制系统。该系统采用独特的过程在线仿真技术和多级分布式结构，实现了监督优化控制、自动控制等先进控制功能。