Prolactin, growth hormone and the immune system in humans

Prolactin (PRL) and growth hormone (GH) qualify as lymphoid growth and differentiation factors. Yet, long-standing hyper- or hyposecretion of PRL or GH does not induce any significant alteration of the immune system. Subclinical changes in laboratory parameters (such as chemotaxis or phagocytosis by granulocytes or macrophages or natural killer cell activity) have been reported in some of these conditions. The GH-insulin-like growth factor (IGF)-I axis is dysregulated in ageing, in catabolic states and in critical illness. Immune parameters, such as infection rate, are being monitored during clinical trials with GH or IGF-I. Hyperprolactinaemia may play an aggravating role in systemic lupus erythematosus, in autoimmune thyroiditis and in other autoimmune diseases. The patient may benefit from increased alertness about interactions between the endocrine and immune systems.     

唾液腺多形性腺瘤及癌在多形性腺瘤中hMSH2、hMLH1蛋白的表达和意义

探讨错配修复基因hMSH2、hMLH1蛋自在唾液腺多形性腺瘤及癌在多形性腺瘤中的表达及意义。免疫组织化学SP法检测涎腺多形性腺瘤27例及癌在多形性腺瘤中蜡块标本22例,共49例标本hMSH2、hMLH1蛋白的表达情况。涎腺多形性腺瘤瘤旁正常组织、涎腺多形性腺瘤和癌在多形性腺瘤组织中hMSH2、hMLH1蛋白表达的阳、性率分别为28．57％和42．86％、96．3％和85．19％及90．91％和86．36％。hMSH2及hMLH1在涎腺多形性腺瘤和癌在多形性腺瘤组织中均表达上调。     

直肠管状腺瘤自发破裂1例报告

直肠管状腺瘤自发破裂在临床罕见,死亡率高,因此必须引起临床医生重视.     

54例累及颅底的鼻咽癌、脊索瘤及垂体瘤的MRI影像

目的:探讨累及颅底的鼻咽癌、脊索瘤和垂体瘤MRI影像特点,以期提高对其鉴别诊断水平.方法:搜集经病理证实的累及颅底的28例鼻咽癌、10例脊索瘤及16例垂体瘤,比较分析其MRI表现. 结果:本组鼻咽癌在T1WI上有10例表现为等信号,18例表现为稍低信号;在T2WI上10例表现为等信号,18例表现为稍高信号,形态不规则,边界不清.脊索瘤10例在T1WI上均表现为信号欠均匀,以低信号为主,混杂有等信号,其中有1例伴有斑片状高信号影;T2WI上均表现为不均匀明显高信号,为分叶状肿块,边界较为清楚.垂体瘤16例在T1WI上表现为均匀等信号或稍低信号,边界清楚,其中4例肿瘤内有出血.28例鼻咽癌的肿瘤中心部位均位于一侧的鼻咽侧壁;脊索瘤10例中有9例肿瘤的中心部位在颅底中线处的斜坡,1例肿瘤的中心部位在左侧枕骨、颞骨交界区;16例垂体瘤的肿瘤中心部位位于蝶鞍.结论:根据MRI信号特点、肿瘤中心点部位和边缘情况,大多数累及颅底的鼻咽癌、脊索瘤和垂体瘤可以作出正确诊断.     

体外培养人涎腺多形性腺瘤细胞及表面标记物的初步研究

体外培养15例人涎腺多形性腺瘤原发肿瘤组织,探讨体外培养的细胞与原发肿瘤组织的表面标志物表达情况。运用免疫组化法检测CK5/6、CK7、CK8/18、CK14、CK20,vimentin及肌上皮表面标记物α-SMA、calponin及p63在细胞和肿瘤组织中的表达。结果发现体外培养的多形性腺瘤细胞呈多样形,可同时表达角蛋白、肌上皮表面标记物及波形蛋白,与原发肿瘤表达基本一致。提示体外培养的多形性腺瘤细胞可能大部分来源于肌上皮细胞及导管上皮细胞等,这为研究涎腺多形性腺瘤肿瘤生物学多样性提供了实验依据。     

Case Report： Adrenal myelolipoma within myxoid cortical adenoma associated with Conn＇s syndrome

The coexistence of myelolipoma within adrenal cortical adenoma is extremely rare, for both tumors present usually as separate entities. There are only 16 such cases reported worldwide. To the best of our knowledge, the case we reported here is the first one of myxoid adrenal cortical adenoma associated with myelolipoma reported. A 32-year-old Chinese woman with 4-year history of hypertension was presented in our study. Computed tomography （CT） of the abdomen showed a large heterogeneously-enhancing mass （4.5 cm in diameter） in the left suprarenal region. Clinical history and laboratory results suggest a metabolic disorder as Conn＇s syndrome. The patient underwent a left adrenalectomy, and a histopathological study confirmed the mass to be a myxoid adrenal cortical adenoma containing myelolipoma. The patient was postoperatively well and discharged uneventfully. In the present case report, we also discuss the etiology of simultaneous myelolipoma and adrenal adenoma associated with Conn＇s syndrome, and the methods of the diagnosis and differential diagnosis.