A decrease in the estimated frequency of the extended HLA haplotype B18 CF130 DR3 DQw2 is common to non-insulin-dependent diabetes,juvenile rheumatoid arthritis,and Berger's disease

Extended HLA haplotypes frequencies were estimated from the HLA, C2, Bf and C4 phenotypes of 74 patients with non-insulin-dependent diabetes (NIDD), 92 with juvenile rheumatoid arthritis (JRA), 44 with Berger's disease (BD), 83 with insulin-dependent diabetes (IDD), and 140 healthy controls. The extended HLA haplotype B18 CF130 DR3 DQw2, which is common (around 10% phenotype frequency) in healthy Spaniards and in other populations of paleo-North African origin, was found to be significantly less frequent in NIDD, JRA and BD, whereas its frequency was normal in IDD (although DR3 DQw2 haplotypes were increased in the latter disease). These data support the existence of a common HLA-linked pathogeneic mechanism in NIDD, JRA and BD, and point to a genetic difference between IDD and NIDD at the HLA level. This effect is readily detectable in our population because the uncommon BfF1 allele marks that haplotype instead of the more common BfS, which marks B8 CS01 DR3 DQw2 in other Caucasians. Our results support the hypothesis of strong selective pressures operating at the HLA level to preserve extended HLA haplotypes with advantageous gene sets from dilution by crossing-over. Imbalanced incomplete haplotypes may give rise to inappropriate T-cell repertoire selection in the thymus and/or antigen handling in the periphery, and be partly responsible for the pathogenesis of certain HLA-linked diseases (i.e. NIDD, JRA, and BD).     

瞬态特征小波分析在心率变异性研究中的应用

瞬态分析是心率变异性研究中富有挑战性的课题 .利用小波变换表征信号瞬态特征的能力 ,对静卧 -心算实验诱发的R R间期瞬态边沿进行了李氏指数和平滑因子的分析 .发现健康样本的李氏指数大于冠心病样本 ,并对此进行了初步的解释 .     

The polymerization of sickle hemoglobin in solutions and cells

The polymerization of sickle hemoglobin occurs by the same mechanisms in solutions and in cells, and involves the formation of 14 stranded fibers from hemoglobin molecules which have assumed a deoxy quaternary structure. The fibers form via two types of highly concentration-dependent nucleation processes: homogeneous nucleation in solutions with hemoglobin activity above a critical activity, and heterogeneous nucleation in similarly supersaturated solutions which also contain hemoglobin polymers. The latter pathway is dominant, and creates polymer arrays called domains. The individual polymers bend, but also cross-link, and the resulting mass behaves as a solid. The concentration of polymerized hemoglobin increases exponentially unless clamped by rate limiting effects such as oxygen delivery.     

南昆线膨胀岩路基基床病害整治方法探讨做

简述了南昆线膨胀岩路基分布情况与况及其工程地质特征,并简述了病害情况. 综述了现有的膨胀岩路基基床病害的整治方法. 通过工程实例对南昆线膨胀岩路基基床病害的整治方法进行研究,总结出南昆线膨胀岩路基基床病害较适宜的整治方法.     

浅论新时期大学生的心理卫生

心身疾病是新时期大学生的常见病和多发病，它是我们培养身心健康的跨世纪人士的一大障碍，本阐述了新时期大学生心身疾病产生的原因及其对策，介绍了大学生常见的心身疾病和心理健康的基本标准。     

冠心病发病因素的调查

文章对社区 318名 5 0岁以上的人进行了调查分析。结果表明 :冠心病是社区居民中最常见的疾病之一     

甘薯病毒病的症状类型及田间消长规律

发生在南充的甘薯病毒病的症状共3类16种,其中花叶类2种,坏死类8种,畸形类6种.其田间消长规律是:①多数症状在育苗期表现充分,临近扦插前进入尾声,仅黄色羽斑、紫色羽斑和褐色斑点入秋后才转入高发期.②除黄色斑驳和紫色羽斑的表现不受气温变化的影响外,其它症状表现的适宜气温是20—27℃,超过30℃和低于18℃便出现隐潜现象.各症状对鲜薯产量都有一定的影响,其中黄化矮缩、紫色羽斑和鸡爪叶甚至造成30%左右的大幅度减产.     

眼表上皮疾病的基础与临床研究进展

针对眼表上皮疾病的基础及临床方面进行了系统研究,包括角膜上皮干细胞的生理,眼表免疫,眼表上皮细胞黏蛋白表达及功能,眼表鳞状上皮化生的发病机制,干眼的诊断与治疗,角膜组织工程,新生血管性眼病的发生机制与治疗等,并在这些方向取得了一系列研究成果.     

模糊综合评价法在拱桥健康诊断中的应用研究

应用基于层次分析法的多级模糊综合评判原理来评价拱桥的工作状态,快捷、准确地了解桥梁的整体安全状况,为其加固、改造提供依据．     

高光谱数据在水稻含氮量监测中的应用

利用SVCHR-768便携式地物光谱仪对唱凯示范田基地的水稻进行反射光谱测定,同时采取样本进行氮含量的测定,以及光谱因子的筛选。结果表明,绿峰峰值是水稻氮含量分析的最佳因子,回归分析得到的模型相关系数为0．782,预测精度较好,约为92．5％。