Association of cystatin C level and cardiovascular prognosis for patients with preexisting coronary heart disease： a meta-analysis

The association of circulating levels of cystatin C （CysC） and risk of recurrent cardiovascular events in patients with preexisting coronary heart disease are uncertain. To qualitatively and quantitatively address this issue, we performed a random meta-analysis of results from prospective studies on the topic. We searched elec- tronic and printed sources （up to 16 October 2011） using keywords and retrieved articles for seven prospective studies according to the selection criteria. Data were abstracted and meta-analysis was performed using the random-effects model （RevMan 5.0.23 software）. The cohorts involved 4,576 patients with preexisting coronary heart disease （CHD） and normal or mild chronic kidney disease, and follow-up ranged from 5.6 to 40.6 months. Highest versus lowest baseline CysC level was signifi- cantly associated with increased risk of cardiovascular events （OR 2.30, 95 % CI 1.80-2.94）, all-cause mortality （OR 5.69, 95 % CI 3.70-8.74）, but not with recurrent MI （OR 1.75, 95 % CI 0.77-4.00）. In heterogeneity testing for studies reporting cardiovascular events and all-cause mor- tality, no significant heterogeneity was found, and exclu- sion of any single study did not alter the overall finding. For risk of recurrent MI, significant heterogeneity was found among the five trials （Z2= 13.16, P=0.01, 12 = 70 %） and exclusion of the Taglieri et al. [12] study from the analysis resulted in a rise in relative risk （OR 2.36, 95 % CI 1.09-5.15）. In conclusion, for patients with established CHD, high baseline level of CysC is associated with increased risk of cardiovascular events and all-cause death during long-term follow-up.     

额颞痴呆与Pick病

额颞痴呆(frontotemporal dementia,FTD)是以额颞叶萎缩为特征的一组神经变性疾病。病因认为是轴索病变继发神经细胞改变,机制为常染色体显性遗传。病理为双侧额叶,颞叶前端的局限性萎缩,可累及尾状核、壳核、丘脑、黑质等皮质下结构。起病隐袭,早期症状为行为、人格改变,渐进性发展为认知功能损害,迅速进展为语言障碍,晚期通常沉默不语,不能与人交流,可有行为异常。MRI显示额叶、前颞叶萎缩。确诊依赖于病理学证据,如局限性额颞叶萎缩,神经元和神经胶质发现tau蛋白包涵体及Pick小体细胞。目前无特异性治疗的治疗方法。     

成都市门诊特殊疾病管理的现状与思考

本文通过对成都市门诊特殊疾病基本情况、管理现状及成效和存在问题的分析,探讨解决对策,进而推进门诊特殊疾病管理工作。     

维吾尔族的近亲结婚率及其遗传学效应

不同类型的近亲结婚,在不同程度上提高常染色体隐性遗传病基因的纯合率,从而大大提高常染色体隐性遗传病的发病率,因此近亲结婚是降低民族遗传素质的重要因素.     

中草药防治鳖暴发性传染病

科果介绍鳖常见暴发性传染病的病原和预防措施，重点阐述了实践中筛选出来的防治鳖白点病，红脖子病，疖疮病，白底板病、出血病和腮腺炎等６种暴发性传染病的中草药配伍方剂，及其使用剂量和使用方法。     

广西大学女教工妇科病调查分析

对广西大学８９８名已婚女教工妇科病进行调查分析，结果发现女教工妇科病总发病率为４５．１％，其中几种常见病如子宫颈炎、阴道炎、子宫肌瘤发病率分别为２８．１％，４．７％，４．０％。其次为更年期，为４１．９％，老年期最低，为１１．９％，依据以上的发率规律，提出防治措施。     

Deficiency of kallikrein-like enzyme activities in cerebral tissue of patients with alzheimer's disease

Summary We examined the changes in the intracerebral activities, at the time of postmortem autopsy, in patients with Alzheimer's disease. When compared with the control group, the activity of kallikrein-like enzyme was significantly decreased, while prolyl endopeptidase activity increased, in the patients group. Aprotinin inhibited 50% of the activity of the former enzyme at 2×10^–7M. Taken together with the results of a multivariate study, the above findings may indicate that intracerebral kallikrein deficiency plays an important role in the pathogenesis of Alzheimer's disease.     

棉花枯萎病的解剖学研究

棉花枯萎病是棉花的一种重要病害。本文从植物解剖学研究其病菌入侵途径,病菌与各器官结构的关系。菌丝的入侵主要在苗期感染下胚轴及其根系,亦可见于子叶,在根、茎中菌丝主要定殖于最初形成的次生木质部。文中对被感染的各类细胞做了统计分析,认为不是因导管被菌丝或侵填体堵塞致病。     

苹果轮纹病的发生与防治

介绍了苹果轮纹病的成因，发病机理及症状等，提出了一些综合防治措施，如选栽抗病品种和抗病砧木，加强栽培管理等。