全文获取类型
收费全文 | 3439篇 |
免费 | 117篇 |
国内免费 | 255篇 |
专业分类
系统科学 | 79篇 |
丛书文集 | 88篇 |
教育与普及 | 37篇 |
理论与方法论 | 4篇 |
现状及发展 | 119篇 |
综合类 | 3472篇 |
自然研究 | 12篇 |
出版年
2024年 | 9篇 |
2023年 | 28篇 |
2022年 | 42篇 |
2021年 | 41篇 |
2020年 | 43篇 |
2019年 | 38篇 |
2018年 | 52篇 |
2017年 | 51篇 |
2016年 | 49篇 |
2015年 | 77篇 |
2014年 | 101篇 |
2013年 | 111篇 |
2012年 | 154篇 |
2011年 | 156篇 |
2010年 | 128篇 |
2009年 | 160篇 |
2008年 | 130篇 |
2007年 | 207篇 |
2006年 | 185篇 |
2005年 | 189篇 |
2004年 | 146篇 |
2003年 | 137篇 |
2002年 | 156篇 |
2001年 | 160篇 |
2000年 | 134篇 |
1999年 | 120篇 |
1998年 | 129篇 |
1997年 | 94篇 |
1996年 | 87篇 |
1995年 | 90篇 |
1994年 | 97篇 |
1993年 | 71篇 |
1992年 | 73篇 |
1991年 | 68篇 |
1990年 | 94篇 |
1989年 | 72篇 |
1988年 | 59篇 |
1987年 | 37篇 |
1986年 | 16篇 |
1985年 | 20篇 |
排序方式: 共有3811条查询结果,搜索用时 15 毫秒
261.
贝尔定理与电子自旋 总被引:1,自引:1,他引:0
谭天荣 《青岛大学学报(自然科学版)》2002,15(3):45-50
本文证明,在贝尔定理的证明过程中,实际上用到电子自旋(或其他费米子的自旋)的任意两个分量的联合概率,而这一联合概率却并不存在,因此,贝尔定理言之无物。贝尔的工作的意义是通过“自旋相关函数”的“隐变量表达式”或其他公式,在这种纯属子虚的联合概率与现实的跃迁概率之间建立一种人为的关系,并引出一个矛盾,从而证明这两种概率各自遵循不同的规律。这一工作既不涉及定域性原理也与经典概率论无关。 相似文献
262.
Horvat A Nikezić G Petrović S Kanazir DT 《Cellular and molecular life sciences : CMLS》2001,58(4):636-644
The subsynaptosomal distribution and specific binding of 17beta-estradiol in vitro to mitochondria isolated from presynaptic nerve endings of female rat brain were examined. 17Beta-estradiol is (i) distributed unequally in synaptosomes and mitochondria posses the highest capacity to bind estradiol with respect to the available amount of the hormone. (ii) Estradiol binds specifically to isolated synaptosomal mitochondria. A Michaelis-Menten plot of specific binding was sigmoidal within a concentration range of 0.1-5 nM of added estradiol, with a saturation plateau at 3 nM. Binding of higher estradiol concentrations demonstrated an exponential Michaelis-Menten plot, indicating non-specific binding to mitochondria. Vmax and Km for the sigmoidal-shape range were estimated as 46 +/- 6 fmol of estradiol/mg of mitochondrial proteins and 0.46 +/- 0.07 nM free estradiol respectively. (iii) Estradiol binding is not affected by the removal of ovaries. The results show that inhibition of Na-dependent Ca2+ efflux from mitochondria by estradiol occurs according to an affinity change of the translocator for Na+, at the same estradiol concentrations that show specific binding to mitochondrial membranes. These data imply that physiological concentrations of estradiol, acting on mitochondrial membrane properties, extragenomically modulate the mitochondrial, and consequently the synaptosomal content of Ca2+, and in that way exert a significant change in nerve cell homeostasis. 相似文献
263.
Analysis of nuclear apoptotic process in a cell-free system 总被引:2,自引:0,他引:2
We report an analysis of the apoptotic process of mouse liver nuclei induced in a cell-free carrot cytosol system by cytochrome
c. Typical characteristics of apoptosis were observed, such as chromatin condensation, margination, apoptotic bodies and DNA
ladders. Furthermore, transmission and scanning electron microscope analysis of the apoptotic nuclei detected chromatin-free
nuclear vesicles before apoptotic bodies appeared at a comparatively late phase. When AC-YVAD-CHO, an inhibitor of caspase
6, was introduced into the system, these vesicles and apoptotic bodies disappeared completely within our study sections. We
confirmed the results using whole-mount electron microscopy, and found that although the nuclear lamina was destroyed early,
the nuclear matrix largely remained intact during the course of apoptosis. The nuclear matrix played an important role in
maintaining the integrity of apoptotic cells and connecting the apoptotic bodies and apoptotic nucleus.
Received 29 September 2000; revised 10 December 2000; accepted 13 December 2000 相似文献
264.
从等价电子组态的"自旋因式化"出发,导出了nsN~nhN组态的Lα、Lβ取值规则,给出了推求等价电子组态光谱项的简易方法. 相似文献
265.
WANGYutang WENYunyi MANing SHILei 《科学通报(英文版)》2003,48(24):2710-2714
The cardiac protective role of a novel erythro-cyte-derived depressing factor (EDDF) on spontaneous hy-pertensive rats (SHR), calcium overload (CaO) rats and Wistar rats and its mechanism was evaluated. Mean artery pressure (MAP), heart rate (HR) and LVdp/dtmax were measured by physiological recorder. The effect of EDDF on the Ca2+-ATPase activity in myocardial sarcoplasmic reticu-lum (SR) of CaO rats was determined by inorganic phos-phate assay. Calcium transport in myocytes was measured by 45Ca2+ radioactive isotope measurement. The phosphoryla-tion levels of extracellular signal-regulated protein kinases (ERK1/2) in myocardial tissue of SHR and CaO rats were measured by Western blot method. And the ultrastructures of cardiac muscle cells were observed with the transmission electron microscope. The results indicated that EDDF could significantly decrease MAP, HR and LVdp/dtmax in a dose dependent manner (P < 0.05). It seems that the mechanism might relate with activating the Ca2+-APTase, enhancing the uptake and release of Ca2+ from SR (P < 0.05), decreasing the phosphorylation levels of ERK1/2 of myocytes (P < 0.01) and lightening the ultrastructural lesion of cardiac muscle cells. In CaO rats, the Ca2+-ATPase activity decreased clearly com-pared to control (64.99 7.16 vs 94.48 7.68 nmol·min-1 ·mg-1 protein, P < 0.01), while EDDF (100 mg/mL) could significantly increase the activity (87.93 ?9.54 vs 64.99 ?7.16, P < 0.05, n = 7). Both uptake and release rate of Ca2+ (祄ol 45Ca2+/g protein/min) from myocardial SR of CaO rats re-markably decreased compared to control (32.40 ?2.70 and 15.46 ?1.49 vs 61.09 ?10.89 and 25.47 ?4.29, P < 0.05); EDDF (100 mg/mL) could significantly stimulate their activi-ties (50.48 6.76 and 21.76 2.75 vs 32.40 2.70 and 15.46 1.49, P < 0.05). EDDF could evidently down-regulate the phosphorylation of ERK1/2 in myocardial tissue from SHR and CaO rats (P < 0.01), lighten the ultrastructural lesion of cardiac muscle cells of SHR as well. It is concluded that EDDF seems to play protective roles on both structure and function of heart, which closely related with amelioration of Ca2+ transport and inhibition of Ca2+-MAP kinase pathway. 相似文献
266.
Scarborough GA 《Cellular and molecular life sciences : CMLS》2000,57(6):871-883
Living cells require membranes and membrane transporters for the maintenance of life. After decades of biochemical scrutiny, the structures and molecular mechanisms by which membrane transporters catalyze transmembrane solute movements are beginning to be understood. The plasma membrane proton-translocating adenosine triphosphatase (ATPase) is an archetype of the P-type ATPase family of membrane transporters, which are important in a wide variety of cellular processes. The H+-ATPase has been crystallized and its structure determined to a resolution of 8 angstrom in the membrane plane. When considered together with the large body of biochemical information that has been accumulated for this transporter, and for enzymes in general, this new structural information is providing tantalizing insights regarding the molecular mechanism of active ion transport catalyzed by this enzyme. 相似文献
267.
Zheng Xiaojing 《中国科学基金(英文版)》2007,15(1):29-33
It is very necessary for the investigation on mechanism of windblown sand movement to understand and find out effective measures of preventing and reducing danger of windblown sands,which also deals with some general characters and hot spots in the scient 相似文献
268.
269.
分别构造了具有小世界和无标度拓扑结构的束流输运网络,为了实现网络多目标同步控制的目的,把束流输运网络按照需要分成多局域网络,采用多局域网络的全局耦合分局域控制方法,实现了分区局域网络中各自所需的多目标(不动点和周期态等)的稳定控制.该方法可以拓广应用于其他复杂网络的多目标控制. 相似文献
270.
严格求解了由Moniz和Sharp导出的非相对论经典电子方程.结果表明当电子半径大于一个临界长度时,方程的解表现出良好的性质,不会出现奔离和预加速的现象.这个特定的长度也是对经典电动力学适用范围的一个粗略估计. 相似文献