应用蚕豆根尖微核技术对环境物质诱变效应的研究

目的:为探讨环境物质诱变效应实验技术的可行性。方法:利用蚕豆根尖微核技术,应用水样及中药提取液诱变蚕豆根尖微核进行实验方法研究,同时辅以水的理化检验指标,进一步找出水中化学成分与微核的关系。结果:化学毒物有致突变性,而某中药提取液有抑制突变的作用。结论:作为化学毒物致突变性和中药提取液抑制突变研究用蚕豆根尖微核技术是经济实惠的,为今后此方面的研究工作提供科学依据。     

基于TCMSP抗肿瘤中药小分子EGFR-TKI的研究

目的研究分析中药小分子表皮生长因子受体酪氨酸激酶抑制剂(EGFR-TKI)的抗肿瘤情况。方法挖掘中药系统药理学数据库与分析平台(TCMSP)中药小分子表皮生长因子受体抑制剂,利用反向分子对接服务器(DRAR-CPI)进行靶点验证。结果木犀草素、槲皮素、金雀异黄酮、表没食子儿茶素没食子酸酯、漆黄素5种中药小分子与表皮生长因子受体(EGFR)结合良好。结论中药小分子EGFR-TKI能从多个靶点、多种途径抑制肿瘤细胞的生长和扩散,利用中药小分子开发新一代多靶点EGFR-TKI具有广阔的前景。     

人工全髋关节置换术研究现状与展望

人工全髋关节置换术(Total hip arthroplasty THA)是治疗终末期髋关节疾病的快速恢复髋关节功能的有效方法之一,现就人工全髋关节置换术中假体的材料应用与界面配伍、微创手术入路选择、数字骨科发展对THA的意义、手机APP在康复指导和追踪随访中的应用等几方面进行综述.     

Stimuli-responsive polymeric materials for human health applications

Stimuli-responsive polymers have the extraor- dinary ability to change their physical and/or chemical state after they ＂detect＂ a change in their environment; their response depends dramatically on their chemical compo- sition. This property has been used for a plethora of applications; this review highlights their utility for human health. Specifically, this review will highlight efforts in the areas of sensing and biosensing, antimicrobial/antifouling coatings, tissue engineering and regenerative medicine, and drug delivery. Specific examples are given in each of these areas, with some focus on our work engineering poly（N- isopropylacrylamide）-based microgels and other respon- sive systems.     

Between meaning culture and presence effects: contemporary biomedical objects as a challenge to museums

The acquisition and display of material artefacts is the raison d’être of museums. But what constitutes a museum artefact? Contemporary medicine (biomedicine) is increasingly producing artefacts that do not fit the traditional museological understanding of what constitutes a material, tangible artefact. Museums today are therefore caught in a paradox. On the one hand, medical science and technologies are having an increasing pervasive impact on the way contemporary life is lived and understood and is therefore a central part of the contemporary world. On the other hand, the objects involved in medical diagnostics and therapies are becoming increasingly invisible and intangible and therefore seem to have no role to play as artefacts in a museum context. Consequently, museums are at risk of becoming alienated from an increasingly important part of contemporary society. This essay elaborates the paradox by employing Gumbrecht’s (2004) distinction between ‘presence’ and ‘meaning’.     

Causes as proximate events: Thomas Brown and the Positivist interpretation of Hume on causality

A neglected episode in the intellectual history of the Scottish Enlightenment, Thomas Brown’s philosophy has been recently reassessed and reconnected with the emergence of the Positivist interpretation of David Hume. In fact, aiming to defend Hume’s philosophy from the common charges of atheism and scepticism, Brown popularised an interpretation of Humean texts which was later to become the standard view on Hume. In this essay, I aim to identify Brown’s historical sources and connect his reading of Hume with the medical discussion on causality.     

养生文化在景观设计中的应用——以北京地坛中医药养生文化园环境景观设计为例

以"针对大众,神形兼备,通俗易懂,知行统一"为指导思想,突出和谐养生主题,设计了一个集养生知识宣传、养生习操、互动体验与休闲娱乐于一体的主题公园.把中医药养生文化应用到园林环境中,成为北京地坛中医药养生文化园的最大特点.     

贵州医药制造业竞争力评价

医药制造业正在成长为贵州经济发展的重要力量。但是通过竞争力评估模型的评价,贵州医药制造业竞争力在全国还处于一般位置。在成长发展力、地区影响力方面,贵州医药制造业处于中上水平;在行业影响力、生产经营力方面处于中下水平。这一方面说明,贵州医药制造业的后发优势明显,具有较好的成长空间与环境,另一方面也反映贵州医药制造业竞争力还需要加强。     

我国鸡球虫耐药性现状及其对策(综述)

对我国田间球虫耐药性现状的分析表明,球虫耐药性十分严重。认为制定合理用药程序、开发中草药制剂、营养调控以及免疫预防是减少球虫耐药性产生和控制鸡球虫病的主要措施,其中研制高效、低毒抗球虫中药制剂及基因工程疫苗为今后的主攻方向。     

根茎类中药粉碎理论有效功耗的研究

在根茎类中药材力学性能实验研究的基础上,设计了刀片剪切实验;建立了根茎类中药粉碎理论有效功耗的数学模型.在实验的基础上求得甘草纵向和横向平均单位面积上的有效功耗分别为4.42×10-3J/mm2和11.16×10-3J/mm2.为根茎类中药粉碎工艺和设备的设计提供了理论参考.