吲哚美辛微生物及自然光降解研究

药品与个人护理品（PPCPs）是一类新型环境微污染物,由于其“假”持久性而受到广泛的关注．微生物和光化学降解是这类物质在自然环境中的主要消减途径．以武汉地区春季太阳光为光源,引入固相萃取方法研究低浓度吲哚美辛在自然环境中的微生物及自然光降解．考察吲哚美辛固相萃取条件,以及不同浓度、基质（Cl-、HCO3-、NO3-、Fe3＋、腐植酸）及共存物（萘普生、呋喃唑酮）对吲哚美辛光降解的影响．实验结果表明,吲哚美辛在东湖水中微生物降解速率较快,而在长江水中降解很微弱．浓度范围为1-500μg／L时吲哚美辛的光降解速率常数（k）与浓度（C）成指数函数．     

湖南山丘区景观生态系统退化特征初探

湖南山地丘陵面积约占全省土地总面积的２／３，是省域最重要的景观生态系统类型。自然状态下，湖南山丘区景观生态系统中景观组分性质优良，景观要素组合协调，景观生态过程稳定，景观功能较强。然而，在长期的人类活动影响之下，湖南山丘区景观生态系统显现出明显的退化特征，具有表现为景观要素组合关系改变、景观组分性质劣化、景观生态过程逆转、景观生态系统抗性降低。     

CTS及M-CTS与Men+的配位

进行了ＣＴＳ的降解,研究了ＣＴＳ及Ｍ－ＣＴＳ与Ｍｅｎ＋的配位．用光谱分析ＣＴＳ及Ｍ－ＣＴＳ与Ｍｅｎ＋的配位结果,提出ＣＴＳ及Ｍ—ＣＴＳ的配位规律．即不同分子量ＣＴＳ的配位能力,低分子量大于高分子量;不同基团的配位能力：－ＮＨ２＞＞—ＯＨ＞—Ｃ＝Ｏ不同金属离子与相同分子量的ＣＴＳ配位,基本遵循与游离氨配位规律．     

4-Hydroxynonenal-modified amyloid-beta peptide inhibits the proteasome: possible importance in Alzheimer's disease

The amyloid β-peptide (Aβ) is a 4-kDa species derived from the amyloid precursor protein, which accumulates in the brains of patients with Alzheimer’s disease. Although we lack full understanding of the etiology and pathogenesis of selective neuron death, considerable data do imply roles for both the toxic Aβ and increased oxidative stress. Another significant observation is the accumulation of abnormal, ubiquitin-conjugated proteins in affected neurons, suggesting dysfunction of the proteasome proteolytic system in these cells. Recent reports have indicated that Aβ can bind and inhibit the proteasome, the major cytoslic protease for degrading damaged and ubiquitin-conjugated proteins. Earlier results from our laboratory showed that moderately oxidized proteins are preferentially recognized and degraded by the proteasome; however, severely oxidized proteins cannot be easily degraded and, instead, inhibit the proteasome. We hypothesized that oxidatively modified Aβ might have a stronger (or weaker) inhibitory effect on the proteasome than does native Aβ. We therefore also investigated the proteasome inhibitory action of Aβ _1–40 (a peptide comprising the first 40 residues of Aβ) modified by the intracellular oxidant hydrogen peroxide, and by the lipid peroxidation product 4-hydroxynonenal (HNE). H₂O₂ modification of Aβ _1–40 generates a progressively poorer inhibitor of the purified human 20S proteasome. In contrast, HNE modification of Aβ _1–40 generates a progressively more selective and efficient inhibitor of the degradation of fluorogenic peptides and oxidized protein substrates by human 20S proteasome. This interaction may contribute to certain pathological manifestations of Alzheimer’s disease Received 26 September 2000; accepted 26 September 2000     

活性炭吸附下TiO2光催化降解苯酚的研究

探索了不同C/TiO2质量比例下,影响苯酚去除率的一些因素.通过实验得到:在单一影响因素下C/TiO2质量的比例为1∶1时效果最佳,降解速度最快;苯酚的起始浓度升高,其降解速度增大,但去除率降低;在pH5～10范围内,pH7时1h去除率最大;TiO2的最佳用量为10g/L.在此条件下,50mg/L苯酚溶液光解2h,去除率达99%以上.     

均聚甲醛降解问题的探讨

对聚甲醛制品特别是均聚甲醛制品的降解在实验论证基础上，指出无论是均聚或者是共聚甲醛，在自然条件下都很难降解，并给出了降解的办法。     

微生物对地表水中石油类污染物的降解研究

针对当前地表水油污染具有面积、低浓度的特点，应用筛选高效降油微生物除油。试验结果表明，投加除油混合菌群，适当充氧，经２４ｈ处理，水中石油类污染物去除率达９０％以上。同时对不同种类油污染物的降解进行了初步研究。     

中国南方农牧复合模式

介绍了新西兰草场管理制度，即利用家畜和豆科植物作为低投入的一种方式维持可持续系统。提出了中国南方农业的发展模式：把边缘耕地与牧地结合起来，切实增加其耕地面积，并对该模式的大面积推广可能遇到的潜在问题，进行了深入分析，指出持续农业的发展不是技术问题，而是“系统”问题。     

Elastase digested urokinase (ED-UK)

Summary Elastase digested urokinase (ED-UK) was prepared from human high mol. wt urokinase (HMW-UK). It resembled low mol. wt urokinase (LMW-UK) in its mol. wt, specific activity, and active sites. The steady-state kinetic parameters of each enzyme for the activation of human Glu-plasminogen also resembled each other, as did their amidase parameters (with pyro-Glu-Gly-Arg-pNA).