全文获取类型
收费全文 | 1568篇 |
免费 | 54篇 |
国内免费 | 100篇 |
专业分类
系统科学 | 84篇 |
丛书文集 | 34篇 |
教育与普及 | 17篇 |
理论与方法论 | 9篇 |
现状及发展 | 120篇 |
综合类 | 1457篇 |
自然研究 | 1篇 |
出版年
2024年 | 5篇 |
2023年 | 23篇 |
2022年 | 46篇 |
2021年 | 21篇 |
2020年 | 35篇 |
2019年 | 20篇 |
2018年 | 23篇 |
2017年 | 29篇 |
2016年 | 29篇 |
2015年 | 43篇 |
2014年 | 76篇 |
2013年 | 45篇 |
2012年 | 66篇 |
2011年 | 96篇 |
2010年 | 70篇 |
2009年 | 85篇 |
2008年 | 82篇 |
2007年 | 116篇 |
2006年 | 107篇 |
2005年 | 89篇 |
2004年 | 92篇 |
2003年 | 89篇 |
2002年 | 72篇 |
2001年 | 53篇 |
2000年 | 44篇 |
1999年 | 44篇 |
1998年 | 28篇 |
1997年 | 35篇 |
1996年 | 31篇 |
1995年 | 19篇 |
1994年 | 25篇 |
1993年 | 10篇 |
1992年 | 14篇 |
1991年 | 17篇 |
1990年 | 8篇 |
1989年 | 6篇 |
1988年 | 8篇 |
1987年 | 5篇 |
1986年 | 5篇 |
1985年 | 7篇 |
1984年 | 2篇 |
1981年 | 1篇 |
1955年 | 1篇 |
排序方式: 共有1722条查询结果,搜索用时 15 毫秒
81.
《Journal of Natural History》2012,46(31):2935-2952
The scales of one high Andean eumaeine lycaenid butterfly species with pale dorsal coloration and four species with vivid dorsal colour were investigated using field emission scanning electron microscopy. The micro‐ and nanostructures are illustrated, described, measured, and interpreted. The vivid colours in the species are caused by a pepper‐pot nanostructure of Urania‐type scales. This nanostructure is a three‐dimensional lattice within the body of the individual scale. The scales of the non‐vivid orange species are lacking this nanostructure and the surfaces of their scales show high microstructure irregularities. This absence of vivid colour may be correlated with thermal regulation. The irregularity of the scale microstructures suggests a heavy environmental pressure on the populations sampled. Previously unknown structural variations of Urania‐type scales are also described. The existence of closed scale microcell structures, explained as an apomorphic character in the tribe Eumaeini, most probably evolved independently several times. It is hypothesized that scale micro‐ and nanostructure modifications develop syntopically within a population, which in turn can lead to rapid diversification. 相似文献
82.
Berger W Steiner E Grusch M Elbling L Micksche M 《Cellular and molecular life sciences : CMLS》2009,66(1):43-61
The unique and evolutionary highly conserved major vault protein (MVP) is the main component of ubiquitous, large cellular
ribonucleoparticles termed vaults. The 100 kDa MVP represents more than 70% of the vault mass which contains two additional
proteins, the vault poly (ADP-ribose) polymerase (vPARP) and the telomerase-associated protein 1 (TEP1), as well as several
short untranslated RNAs (vRNA). Vaults are almost ubiquitously expressed and, besides chemotherapy resistance, have been implicated
in the regulation of several cellular processes including transport mechanisms, signal transmissions and immune responses.
Despite a growing amount of data from diverse species and systems, the definition of precise vault functions is still highly
complex and challenging. Here we review the current knowledge on MVP and vaults with focus on regulatory functions in intracellular
signal transduction and immune defence.
Received 27 June 2008; received after revision 25 July 2008; accepted 30 July 2008 相似文献
83.
运用演化博弈理论研究了互联网金融平台行为及监管策略的博弈演化过程,系统考察了互联网金融平台行为及监管博弈过程的影响因素,并重点对固定惩罚机制和动态惩罚机制下互联网金融平台行为及其监管策略博弈均衡进行了比较.研究表明,固定惩罚机制下,互联网金融平台和金融监管机构的博弈过程不能达到稳定的均衡状态,两个群体的行为呈现周期模式.动态惩罚机制下,互联网金融平台和金融监管机构间的博弈演化轨迹呈螺旋收敛的趋势;互联网金融平台的"自律"的初始概率不同,其随时间演化收敛到不同的均衡值;提高最重惩罚度上限,互联网金融平台选择"自律"行为策略的概率增加. 相似文献
84.
Many notions regarding the function, structure and regulation of cholera toxin expression have remained essentially unaltered
in the last 15 years. At the same time, recent findings have generated additional perspectives. For example, the cholera toxin
genes are now known to be carried by a non-lytic bacteriophage, a previously unsuspected condition. Understanding of how the
expression of cholera toxin genes is controlled by the bacterium at the molecular level has advanced significantly and relationships
with cell-density-associated (quorum-sensing) responses have recently been discovered. Regarding the cell intoxication process,
the mode of entry and intracellular transport of cholera toxin are becoming clearer. In the immunological field, the strong
oral immunogenicity of the non-toxic B subunit of cholera toxin (CTB) has been exploited in the development of a now widely
licensed oral cholera vaccine. Additionally, CTB has been shown to induce tolerance against co-administered (linked) foreign
antigens in some autoimmune and allergic diseases.
Received 25 October 2007; accepted 12 December 2007 相似文献
85.
六垛南闸闸下淤积现状分析 总被引:2,自引:0,他引:2
针对我国在滨海河口地区修建的挡潮闸在河口建闸后普遍存在的泥沙淤积问题,根据苏北灌溉总渠入海口六垛南闸等处的实测资料,分析该挡潮闸下潮汐引河通道冲淤特性,指出挡潮闸下引河的潮流特性、潮流挟沙特性及引河淤积的原因。认为对闸门进行科学合理的控制、有效利用上游有限的泄水量和闸下落潮水流拖淤来防淤减淤是较为简便易行且经济的措施。 相似文献
86.
Betaine homocysteine S-methyltransferase: just a regulator of homocysteine metabolism? 总被引:1,自引:0,他引:1
Betaine homocysteine methyltransferase (BHMT), a Zn2+-dependent thiolmethyltransferase, contributes to the regulation of homocysteine levels, increases in which are considered
a risk factor for cardiovascular diseases. Most plasma homocysteine is generated through the liver methionine cycle, in which
BHMT metabolizes approximately 25% of this non-protein amino acid. This process allows recovery of one of the three methylation
equivalents used in phosphatidylcholine synthesis through transmethylation, a major homocysteine-producing pathway. Although
BHMT has been known for over 40 years, the difficulties encountered in its isolation precluded detailed studies until very
recently. Thus, the last 10 years, since the sequence became available, have yielded extensive structural and functional data.
Moreover, recent findings offer clues for potential new functions for BHMT. The purpose of this review is to provide an integrated
view of the knowledge available on BHMT, and to analyze its putative roles in other processes through interactions uncover
to date.
Received 26 May 2006; received after revision 3 July 2006; accepted 24 August 2006 相似文献
87.
Identification of rate-limiting steps or components of intracellular second messenger systems holds promise to effectively
interfere with these pathways under pathological conditions. The emerging literature on a recently identified family of signalling
regulator proteins, called tribbles gives interesting clues for how these proteins seem to link several ‘independent’ signal
processing systems together. Via their unique way of action, tribbles co-ordinate the activation and suppression of the various
interacting signalling pathways and therefore appear to be key in determining cell fate while responding to environmental
challenges. This review summarises our current understanding of tribbles function and also provides an evolutionary perspective
on the various tribbles genes.
Received 10 January 2006; received after revision 20 March 2006; accepted 5 April 2006 相似文献
88.
在江苏淮地区的新垦土生荒土上,对水稻-小麦-水稻、水稻-油菜-水稻、水稻-绿肥-水稻3种种植模式不同施肥下的氮、磷、钾产投入与土壤肥力关系进行了分析,结果表明:在生荒土上,随着各植年限的增加,氮、磷的产股比有 大的提高。三季种植后,土壤有机质净增量与有机质投入量,总投氮与土壤全氮、碱解氮,总投磷量与土训速 效磷,总投钾量与速效钾呈显著正相,肥料投入对土土壤肥力演变起决定性作用,表6,参12。 相似文献
89.
文章对美、英、德等主要发达国家的劳动安全监管体制进行了介绍,对其劳动安全监管中的成功经验加以分析、借鉴,对我国劳动安全监管体制进一步改革提出了相应对策。 相似文献
90.
由于我国网络型公用事业立法滞后于经济的发展,导致了在民营化过程中出现了网络型公用事业的法律规制不完善、政府规制的体制与手段不健全和民营化缺乏竞争机制的保障等问题。本文以网络型公用事业民营化为视角,突出从经济学角度对网络型公用事业的垄断性与民营化的可行性进行分析,并试图构建一套符合中国国情的网络型公用事业法律规制模式。 相似文献