Sugar-mimicking glycosidase inhibitors: bioactivity and application

A large number of compounds mimicking the structures of monosaccharides or oligosaccharides have been discovered from natural sources. Such sugar mimics inhibit carbohydrate-degrading enzymes because of a structural resemblance to the sugar moiety of the natural substrate. Carbohydrate-degrading enzymes are involved in a wide range of important biological processes, such as intestinal digestion, posttranslational processing of the sugar chain of glycoproteins, their quality control mechanisms, lysosomal catabolism of glycoconjugates, and some viral infections. It has now been realized that inhibitors of the enzymes have enormous therapeutic potential in diabetes and lysosomal storage disorders. In this review, the general bioactivity, current applications, and the prospects for new therapeutic applications are described. Received 27 August 2008; received after revision 08 November 2008; accepted 03 December 2008     

Antizyme inhibitor: mysterious modulator of cell proliferation

In contrast to the considerable interest in the oncogene ornithine decarboxylase (ODC) and in the family of antizymes with regard to cell proliferation and tumorigenesis, the endogenous antizyme inhibitor (AZI) has been less well studied. AZI is highly homologous to the enzyme ODC but does not possess any decarboxylase activity. Elevated ODC activity is associated with most forms of human malignancies. Antizymes bind ODC, inhibit ODC activity and promote the ubiquitin-independent degradation of ODC. Consequently they are proposed as tumor suppressors. In particular, the most studied member of the antizyme family, antizyme 1, has been demonstrated to play a role in tumor suppression. AZI inactivates all members of the antizyme family, reactivates ODC and prevents the proteolytic degradation of ODC, which may suggest a role for AZI in tumor progression. Received 9 December 2005; received after revision 13 April 2006; accepted 1 June 2006     

原子第二宇宙速度与电离能普遍公式的推导、实验验证和理论预言

提出了“原子第二宇宙速度”这一新概念,并根据此概念推导出了单电子原子和离子的原子第二宇宙速度和电离能的普遍公式。根据这些公式计算出了100余种单电子原子和离子电离能的具体数值,计算数据与实验数据符合得很好,从而使这一新的理论和计算获得了成功。因现今实验技术的局限性,有些单电子离子的电离能实验值尚未被科学界测出,我们的理论计算值就作为理论预言列出,已获得的成功使我们有理由相信它们将会获得实验验证。本文的概念和计算显然涉及到经典物理与量子物理的关系等原则问题,其物理本质将在后面两篇文章中论述。     

江西省新型材料科技发展战略的研究与思考

简要介绍和分析了国内外材料领域科技发展趋势和江西材料工业发展的现状及特点.提出了江西发展新型材料产业的战略思想和中长期战略目标.指出要以发展钢铁和有色金属新材料为主导,开发特色化工和陶瓷新材料,发展精深加工,延长产业链,提高资源利用效率,不断提升和加强材料工业在江西经济中的支柱地位.     

A review of Eunotinae (Hymenoptera: Chalcidoidea: Pteromalidae) from China

Five genera of Eunotinae are included in this paper. Ophelosia, Moranila, Cephaleta, Eunotus are reviewed and a new genus Cavitas is described. Four new species, Cavitas concava sp. nov., Eunotus applanatus sp. nov., E. strenus sp. nov. and E. aequalivenus sp. nov. are described. The type specimens are deposited in the Zoological Museum, Institute of Zoology, the Chinese Academy of Sciences.     

高校图书馆新生入馆教育实践

如何高效地利用图书馆获取信息资源是大学生们不可或缺的基本素养,入学之初对大学新生进行入馆教育是重要的一环。本文根据本校图书馆的自身特点,从四个方面对新生入馆教育实践进行了探索,以期新生们尽快地认识大学图书馆,并高效地利用图书馆。     

工程与现代性

现代性是以工程为载体的秩序寻求过程中所展现的矛盾性和悖论性。现代工程作为现代性的最高成果,兼具确定性与不确定性,其不确定性引发工程风险,而现代性的工程化后果又直接导致工程的异化和人的新异化。所以,按照生存论的解释原则,必须看到源自工程异化的人的新异化的工程人类学意味,进而探索解决人类生存危机的有效途径。     

论大学英语听力教材的编写——对《新起点大学英语听力教程》教材的分析

本文首先分析了新形势下对教材建设的新要求,然后对《新起点英语听力教程》在编写形式和原则等方面进行了分析。提出了新教材的一些特点及对提高学生英语能力的帮助,最后对教材的编写提出了一些改进的建议。