叶酸修饰聚酰胺-胺负载5-氟尿嘧啶纳米给药体系的制备及其体外性能研究

使用化学键键合的方式分别将叶酸(FA)和5-氟尿嘧啶-1-基乙酸(FUA)偶联于树状大分子聚酰胺-胺(PAMAM)制备纳米载药体系FA-PAMAM-FUA,并结合单因素分析法筛选出最佳制备条件为FA∶PAMAM∶FUA的物质的量的比为10∶1∶450,p H值为6.用紫外可见光谱、红外光谱和纳米粒度仪对FA-PAMAM-FUA的光学特性、粒径大小和体外释药性能进行了表征.结果表明:优化条件下制备的FAPAMAM-FUA粒径呈正态分布,平均粒径为90.28±20.00 nm,分散度为0.258±0.002(n=3),体系载药量达28.45%,FA-PAMAM-FUA给药体系对药物具有一定的p H敏感特性以及缓释功能.采用MTT法考察了5-Fu、FA-PAMAM-FUA对乳腺癌细胞MCF-7的增殖抑制作用,结果表明两者对MCF-7细胞的增殖具有明显地抑制作用,剂量依赖性强,随浓度的增高,FA-PAMAM-FUA对癌细胞增殖抑制作用较5-Fu明显增强.     

泡沫陶瓷基氢氧化高镍催化剂的制备及模拟污水处理研究

本研究以活性炭为造孔剂制备泡沫陶瓷,通过浸渍法使NiCl2负载于泡沫陶瓷,再与NaClO和NaOH混合溶液反应生成NiOOH催化剂.以一定浓度的亚甲基蓝为污水模拟物,亚甲基蓝褪色时间来衡量NiOOH催化剂的催化性能.以催化剂量、次氯酸钠量、pH、温度为变量,分别通过单因素实验和正交试验探究了它们对催化效果的影响以及确定污水处理的较优组合条件.结果表明,在温度为55℃、pH为8、催化剂量为1.0g、NaClO量为15.0mL时,亚甲基蓝的完全褪色时间为131min.各因素对污水处理效果的影响顺序为温度催化剂量pHNaClO量.污水处理的最佳实用组合条件为温度为35℃、pH为8、催化剂量为1.0g、NaClO量为15.0mL.     

UHPLC-MS/MS法同时测定大鼠血浆中汉黄芩素、隐绿原酸和白杨素-7-O-葡萄糖醛酸苷含量

建立了UHPLC-MS/MS同时测定大鼠血浆中的汉黄芩素、隐绿原酸和白杨素-7-O-葡萄糖醛酸苷含量的方法。以芹菜苷为内标,采用ACQUITY UPLC HSS T3色谱柱(2.1 mm×100 mm, 1.8 μm),乙腈和0.1％甲酸溶液为流动相,流速为0.2 mL·min^-1。结果表明,汉黄芩素、隐绿原酸和白杨素-7-O-葡萄糖醛酸苷线性范围为1～1 000 ng·mL^-1(R2>0.99),最低定量浓度为1 ng·mL^-1,提取回收率、基质效应均符合生物样品分析要求。建立的方法灵敏、准确,可用于大鼠血浆中汉黄芩素、隐绿原酸和白杨素-7-O-葡萄糖醛酸苷的测定及其药代动力学研究。     

A revision of Bovichtus Cuvier, 1831 (Pisces: Bovichthyidae) from Australasia,with description of a new deepwater species from the New Zealand Subantarctic

The genus Bovichtus includes four species from the Australasian region, viz. B. variegatus Richardson, B. psychrolutes Günther, B. angustifrons Regan, and B. oculus n. sp. B. decipiens Regan and Aurion effulgens Waite are junior synonyms of B. variegatus and B. psychrolutes respectively. B. oculus, described from a specimen taken in 847–902 m on the Campbell Plateau in the New Zealand Subantarctic, is the first known deep water Bovichtus species. It differs from all congeners in having a very large eye (horizontal diameter <9·0 times in SL) and, alone with B. psychrolutes, has a patch of ctenoid scales on the body behind the pectoral fin base.     

Membraniporoidea,Microporoidea and Cellarioidea (bryozoa,Cheilostomata) collected by Discovery Investigations

Thirty eight species of anascan Cheilostomata are described from the collections of Discovery Investigations, and other British antarctic expeditions. Ten new species are described, including Stomhypselosaria watersi introduced for Cellaria dubia (Busk) sensu Waters (1904). Two new genera are introduced, and Swanomia nom. nov. is proposed for Mawsonia Livingstone 1928, non Woodward 1907.     

Description of two new species of Guernea (Crustacea,Amphipoda, Dexaminidae) from Japan,with tentative revision of subfamily Prophliantinae

Guernea minor sp. nov. and G. ezoensis sp. nov. are described from Japan. Based on these new species and the literature, a tentative revision of the subfamily Prophliantinae is proposed. The subgenus Prinassus of the genus Guernea is invalidated. The subgenus Haustoriopsis of the genus Guernea is re-elevated to a separate genus from Guernea. Dexaminoculus is transferred from Prophliantinae to Dexamininae.     

The larval development of Petalomera japonica (Henderson) (Decapoda,Dromiidae) reared in the laboratory

The complete larval development of Petalomera japonica (Henderson) is described, based on laboratory rearing. The species has two zoeal stages and a megalopa. Detailed comparisons are made with other dromiid larvae, particularly those of Petalomera wilsoni.     

杂谈新媒体视觉下“微教育”的推广

以新媒体视觉为切入点,以微教育风暴为契合点,以微教育平台为着眼点,借助时尚元素为社区教育添彩,搭乘网络快车为教育工作提速,是当前社区教育直面的时代课题。     

A new species of the genus Scaptognathus (Acari,Halacaridae) from Japan

A new species under the name Scaptognathus ventridiscus sp. nov. is described from Japan. It differs from its congeners by the possession of a ventral disc in the male, a peculiar arrangement of dorsal plates and dorsal setae, and unique leg chaetotaxy.     

基于L-V模型的重庆两江新区生产性服务业与现代制造业协同发展实证研究

为探索生产性服务业与现代制造业之间的竞争与协同互动发展的内在机制,借鉴生物学共生理论,采用LV模型分析、非线性最小二乘、调查访谈等方法分析了两产业之间的协同发展机制,以两江新区为实证分析估算了L-V模型及离散转化模型的相关参数值,并对模型的均衡点和稳定性予以分析并得到均衡点的稳定性特征值;结果表明L-V模型能较好地契合生产性服务业和现代制造业之间的协同发展机制研究,两产业之间存在互利共生、互为支撑,实现共同升级与发展.