随机删失场合下部分线性模型的最近邻估计

主要讨论了随机删失场合下,误差为NA序列时的部分线性模型,利用基于分布函数的最近邻估计和最小二乘法,给出了部分线性模型的参数和非参数部分估计,并得到了参数估计o(n-1/4)的收敛速度和非参数部分的强相合性.     

NA序列Chung型对数律的精确渐近性质

令{ξn,n≥1}为零均值严平稳的负相伴(NA)随机变量序列,满足Eξ12∞和0σ2=Eξ12+2∑k=2∞Eξ1ξk∞.记Sn=∑k=1n ξk,Mn=∑ k=1n|Sk|,n≥1.利用NA序列中心极限定理和概率不等式,对边界函数和拟权函数得到了Chung型对数律的精确渐近性质.     

NA样本下回归函数估计的收敛速度

在误差为NA序列的条件下,研究了固定设计点列下非参数回归函数一般权函数的非参数估计,并在一些基本条件下给出了估计的一致最优强收敛速度。     

论壮族“那文化”的生态发展观

文山壮族在长期的农耕生产生活中形成了独特的“那文化”,在这种文化常态中体现出来的人与自然和谐、社会人际和谐的观念是一种可贵的生态发展观,其理论价值在于：它可以为建设和谐社会、走可持续发展道路提供基础性的社会历史依据和文化价值取向。     

NA样本下双边截断型分布族参数的EB估计

目的在NA样本下研究双边截断型分布族参数的经验Bayes(EB)估计。方法对密度函数采用核估计的方法构造了参数的EB估计。结果在加权平方损失函数下,获得了该估计的收敛速度。结论在适当的条件下,NA样本双边截断型分布族参数的EB估计的收敛速度任意接近O(n-1/2)。     

NA样本下单边截断型分布族位置参数的经验Bayes估计

该文在充分运用同分布 N A样本密度函数的核估计方法的情况下 ,构造出了一类单边截断型分布族位置参数θ的经验 Bayce(EB)估计 ;由分析可知 ,在适当的条件下 ,证明了位置参数θ的 EB估计的收敛速度 O(n- q) ,其中 q =λα(δ -2 ) /(2α + 4)δ,α >0 ,1>λ >0 ,δ >2。     

NA误差下线性模型参数M估计的强收敛速度

在NA误差下讨论了线性回归模型参数M估计的强收敛速度，从而将[1]在独立误差下的线性回归模型参数M估计的强收敛速度推广到NA误差场合。     

Stepwise prediction and statistical screening:B-cell epitopes on neuraminidase of human avian H_5N_1 virus

The B-cell epitopes of virus are associated with the antiviral drug and the vaccine screening. As the nucleotide sequences of neuraminidase (NA) of stain GD-01-06 were sequenced, we predicted the α-helix and β-fold structure and the indexes of the flexible regions of secondary structure of NA with methods of the Hydrophilicity plot by Kyte-Doolittle, the Surface probability plot by Emini and the Antigenic index by Jameson-Wolf, and then screened statistically the parameters to predict B-cell epitopes by the Hierarchical cluster and the Bivariate correlation and the quartiles with SPSS 13.0. The impact of variation of amino acids in NA on its epitopes was analyzed. The predictive results were evaluated by Wu’s Antigenic Index and SWISS-MODEL. We found that the most possible epitopes on NA were located within or nearby its N-terminal Nos. 120―137, 81―84, 408―415, 273―282, 429―432, 356―368, 46―55, 146―155, 341―350 and 198―209, which were the dominant regions of NA epitopes. Peptide 120―137 including the glycoprotein domain (NGT126―128) was first chosen as the B-cell epitopes on NA. NA in H5N1 strain isolated after 2003 lacked in No. 53 amino acid (I), resulting in an increase in the surface flexible region of NA in GD-01-06 and an enlargement to their epitope regions (VEP46―48→ VEPISNTNFL46―55). Conclusively, prediction of the B-cell epitopes on the NA based on multiple parameters is useful for researches on the molecular immunology and drug screening and immuno-prophylaxis. A deletion of No. 53 amino acid (I) in NA in strain GD-01-06 might increase its antigenicity.     

Inducement of Sechenov inhibition by EtOH and NA in the Bufo toad

Central inhibition, discovered by Sechenov in 1862, suggests that electrically stimulating the forebrain or medulla oblongata in frog generally suppresses reflexes. However, the underlying molecular mechanisms are still unclear. Using ethanol (EtOH), noradrenalin (NA), and other neurotransmitters in thalamic preparations, Sechenov inhibition was stimulated in Bufo toads in this study. The result showed that, similar to Sechenov inhibition, the acute application of EtOH or NA excited the thalamus and prolonged the latency of withdrawal reflex. Our study evidences the involvement of α-adrenoceptors in such central inhibition, and explains the role of acute EtOH application in the in- duction of reflex inhibition.