勤务编排问题的关联度识别型遗传算法

为了提高遗传算法求解勤务编排问题时的优化性能,提出一种关联度识别型遗传算法。算法根据勤务的组成结构定义基因关联度,以量化基因之间的联结关系。据此引入基因座优化算子,将勤务集合划分为若干子集合,依次调整各勤务子集对应的染色体结构,使关联度较强的变量基因位置较为靠近。基于这种染色体结构设计多点交叉算子,根据相邻基因的关联度选择交叉点位置,分基因片段完成交叉操作,以便于交叉算子高效交换积木块,达到提高遗传算法寻优效率的目的。实验结果证明,该算法能够有效地求解勤务编排问题。     

一种太阳能驱动自行小车模型设计

利用四杆机构的工作特性,通过内联传动,完成以太阳能为动力源,能够自动转向并且按预定轨迹运行的自行小车模型设计,很好地利用了四杆机构的机械特性,达到了运用简单机构实现复杂运动的目的,同时也体现了低碳环保的理念.     

基于VC＋＋6．0的平面连杆机构运动学模拟

运用复数矢量法对于单自由度平面连杆机构的运动进行了软件模拟和分析。软件建立了机构的位移方程组,利用数值方法求解机构分析中的非线性位移方程组,并利用差分法对于速度和加速度进行了进一步运算,基于VC＋＋6．0编写的软件,实现了图形化的设计运行效果和方便的用户交互,可以用作教学演示或者用于简单的机构运行分析。     

Rate of decay in admixture linkage disequilibrium and its implication in gene mapping

Modeling linkage disequilibria (LD) between genes usually observed in admixed natural populations has been shown an effective approach in high-resolution mapping of disease genes in humans. A prerequisite to obtain accurate estimation of recombination fraction between genes at a marker locus and the disease locus using the approach is a reliable prediction of the proportion of the admixture populations. The present study suggested the use of gene frequencies to predict the estimate of the admixture proportion based on the observation that the gene frequencies are much more stable quantities than the haplotype frequencies over evolution of the population. In this paper, we advanced the theory and methods by which the decay rate of nonlinear term of LD in admixed population may be used to estimate the recombination fraction between the genes. Theoretical analysis and simulation study indicate that, the larger the difference of gene frequencies between parental populations and the more closely the admixture proportion approaches 0.5, the more important the nonlinear term of the LD in the admixed population, and hence the more informative such admixed populations in the high-resolution gene mapping practice.     

齿轮五杆机构连杆曲线的长周期性及其应用

本文提出了齿轮五杆机构的长周期特性,用广义型转化法对这一特性进行了分析,并提出了一个具体的应用实例。     

连杆机构CAI/CAD软件的研制

介绍了连杆机构CAI/CAD软件的结构、功能、特点、开发环境以及解决的关键技术问题.该软件既可用于教学,又可用于工程设计,具有实用价值.     

产生对称连杆曲线铰链四杆机构的几何特征及简单的图解近似综合

讨论了能够产生对称连杆曲线的铰链四杆机构的几何特征。提出了一种简单的图解综合法,它可以综合能够产生对称连杆曲线的铰链四杆机构并使对称的连杆曲线在给定的厚度S(在对称轴方向上)和宽度(在垂直与对称轴方向上)范围内。还提出了一种能产生带有一段近似直线的对称连杆曲线的四杆机构的综合、简单、实用的新方法。     

The human genome and understanding of common disease: present and future technologies

The study of candidate genes over the past three decades has yielded notable successes in common-disease genetics. During this time, however, interpretation of genetic association studies has been hampered by the use of clinical cohorts of inadequate power and insufficient information on genetic variation in candidate genes. The unavailability of highthroughput and low-cost genotyping technologies has also limited the scope of complex-disease genetic studies. More recently, however, the sequencing and characterization of variation within the human genome has revolutionized genetic studies and enabled full genome-wide scans for genes associated with disease. The identification of disease-associated (causative) genes has illuminated disease mechanisms. The translation of this knowledge into direct clinical benefit in diagnosis, prognosis and therapy for an individual’s disease still remains a challenge. Received 11 September 2006; received after revision 17 December 2006; accepted 18 January 2007     

我国煤炭开发利用中跨区域产业联动的可行性分析

产业链研究不仅对产业发展有重要意义,而且对区域经济的发展日益重要。基于产业链的跨区域延伸,首先提出了跨区域产业联动的概念;进而从区域经济角度对我国煤炭产业链的现状进行了具体分析,阐述了所存在的问题,在此基础上指出了煤炭开发利用中进行跨区域产业联动的必要性。     

金融开放条件下利率-汇率联动与金融风险防范

我国利率政策和汇率政策的矛盾给金融市场积聚着风险,而金融开放带来的是对这种风险的放大。为此,分析了金融开放条件下利率政策和汇率政策的联动配合在防范金融风险中应有的作用,并提出加强我国利率-汇率联动,更有效地防范金融风险的政策主张。