太原地区空调系统若干设计问题的探讨

太原地区的气候条件给空调系统设计带来了一些与常规设计有所区别的特点,如在负荷计算,冷热源选择,风量确定,风和水系统设计等方面,掌握这些特点可以在空调系统设计中带来方便。     

Anti-amyloidogenic therapies: strategies for prevention and treatment of Alzheimer’s disease

Deposition of amyloid β-protein (Aβ) in the brain is an early and invariant neuropathological feature of Alzheimer’s disease (AD). The current search for anti-AD drugs is mainly focused on modification of the process of accumulation of Aβ in the brain. Here, we review four anti-amyloidogenic strategies: (i) reduction of Aβ production, which has mainly been approached with secretase inhibition, (ii) promotion of the Aβ degrading catabolic pathway, including an Aβ degrading enzyme, neprilysin, (iii) immunotherapy for Aβ and (iv) inhibition of Aβ aggregation. We have reported that AD patients have a favorable molecular environment for Aβ aggregation and that various compounds, such as polyphenols, interfere with Aβ aggregation and destabilize preformed Aβ fibrils. Received 21 December 2005; received after revision 14 February 2006; accepted 29 March 2006     

Glycogen synthase kinase 3β and Alzheimer’s disease: pathophysiological and therapeutic significance

Alzheimer’s disease (AD) is a neurodegenerative disorder associated with cognitive and behavioral dysfunction and is the leading cause of dementia in the elderly. Several studies have implicated molecular and cellular signaling cascades involving the serine-threonine kinase, glycogen synthase kinase β(GSK-3β) in the pathogenesis of AD. GSK-3β may play an important role in the formation of neurofibrillary tangles and senile plaques, the two classical pathological hallmarks of AD. In this review, we discuss the interaction between GSK-3β and several key molecules involved in AD, including the presenilins, amyloid precursor protein, tau, and β-amyloid. We identify the signal transduction pathways involved in the pathogenesis of AD, including Wnt, Notch, and the PI3 kinase/Akt pathway. These may be potential therapeutic targets in AD. Received 19 December 2005; received after revision 24 January 2006; accepted 6 February 2006     

柯西积分公式的推广

把一般的柯西积分公式integral from n=r(f(z)/((z-z_0)~m)dz=(2πi/(m-1)!f~(m-1)(z_0)推广到被积函数f(z)在周线Γ内部有2个及其以上奇点的情形,并得到了相应的积分计算公式.     

基于素质教育的中学地理教学改革与方法创新

结合中学地理教学目标、教材特点和当代中学生学习环境的变化,提出了基于素质教育的中学地理教师应具备的素质和技能:教师是复合型研究性人才;具有终身学习理念;具有科学方法论做指导;具有跨学科知识结构体系.根据目前中学地理教学的现状和问题,提出了基于素质教育的中学地理教学改革和方法创新的途径:自觉运用哲学理论和逻辑方法;软化学...     

8周健身运动处方教学对保健班学生身体成分的影响

为了解健身运动处方对保健班学生身体成分的影响,对齐齐哈尔大学23名保健班学生进行8周健身运动处方教学,并对所有学生在8周教学前后的体脂百分比、BMI和身体形态等指标进行测试.结果表明,保健班学生实验后的体脂百分比出现一定程度的下降,符合健康标准的人数逐步增多,胸围和呼吸差发生了一定的变化(P<0.05),腰围在低于风险...     

反射起偏实验的改进

随着科学技术的发展,许多传统的物理实验装置需要进行更新,但许多高校不能重新购置全新的设备,故需要自主的对传统的实验设备进行改进.在原有反射起偏实验装置的基础上,加装转动平台及升降平台,通过此项改进,有利于实验操作的进行和实验现象的观察。     

回望乡土——20世纪80年代中国乡土诗发展概览

20世纪80年代中国乡土诗是伴随改革开放的逐步推进而曲折前行的。从宏观和历史的角度来看,80年代乡土诗的整体创作经历了“兴盛→平淡→繁荣”的发展过程,并在题材内容、意象运用等内涵发展方面发生了明显变化,呈现出丰富性、多样化的基本概貌。     

春秋时期鲁国历法研究的一些新观点

在阐述春秋时期鲁国历法研究的历史和现状的基础上,刍议历代春秋时期历法研究均不成功的原因;对月建、两次"日南至"、"三正"、频大月等重要议题进行重新审视;给出春秋时期鲁国244年间各年之岁首日期、JD和干支,并标出置有闰月的年。特别对春秋时期鲁国历法的建正、失闰和超闰等有争议的问题进行深入的研究,论证复原、重现春秋时期鲁国历谱的原则。最后讨论春秋时期各国历法的建正问题。     

Spatial prisoner’s dilemma games with increasing size of the interaction neighborhood on regular lattices

We studied the evolution of cooperation in the prisoner’s dilemma game on a square lattice where the size of the interaction neighborhood is considered. Firstly, the effects of noise and the cost-to-benefit ratio on the maintenance of cooperation were investigated. The results indicate that the cooperation frequency depends on the noise and cost-to-benefit ratio: cooperation reaches a climax as noise increases, but it monotonously decreases and even vanishes with the ratio increasing. Furthermore, we investigated how the size of the interaction neighborhood affects the emergence of cooperation in detail. Our study demonstrates that cooperation is remarkably enhanced by an increase in the size of the interaction neighborhood. However, cooperation died out when the size of the interaction neighborhood became too large since the system was similar to the mean-field system. On this basis, a cluster-forming mechanism acting among cooperators was also explored, and it showed that the moderate range of the neighborhood size is beneficial for forming larger cooperative clusters. Finally, large-scale Monte Carlo simulations were carried out to visualize and interpret these phenomena explicitly.