全文获取类型
收费全文 | 1671篇 |
免费 | 58篇 |
国内免费 | 70篇 |
专业分类
系统科学 | 29篇 |
丛书文集 | 54篇 |
教育与普及 | 13篇 |
理论与方法论 | 13篇 |
现状及发展 | 32篇 |
综合类 | 1657篇 |
自然研究 | 1篇 |
出版年
2024年 | 4篇 |
2023年 | 8篇 |
2022年 | 10篇 |
2021年 | 14篇 |
2020年 | 7篇 |
2019年 | 10篇 |
2018年 | 15篇 |
2017年 | 23篇 |
2016年 | 21篇 |
2015年 | 35篇 |
2014年 | 105篇 |
2013年 | 47篇 |
2012年 | 81篇 |
2011年 | 90篇 |
2010年 | 93篇 |
2009年 | 113篇 |
2008年 | 129篇 |
2007年 | 140篇 |
2006年 | 121篇 |
2005年 | 111篇 |
2004年 | 93篇 |
2003年 | 73篇 |
2002年 | 60篇 |
2001年 | 57篇 |
2000年 | 50篇 |
1999年 | 52篇 |
1998年 | 38篇 |
1997年 | 36篇 |
1996年 | 30篇 |
1995年 | 17篇 |
1994年 | 29篇 |
1993年 | 8篇 |
1992年 | 12篇 |
1991年 | 15篇 |
1990年 | 6篇 |
1989年 | 15篇 |
1988年 | 13篇 |
1987年 | 9篇 |
1986年 | 2篇 |
1985年 | 7篇 |
排序方式: 共有1799条查询结果,搜索用时 15 毫秒
61.
在J2EE架构中数据对象的设计与实现 总被引:1,自引:0,他引:1
从数据流角度出发,基于MVC模式设计要求,对数据对象在不同层之间的传输和转换问题进行了深入分析,设计出基于对象化数据在不同层之间的实现思路,基于网络传输和跨平台性考虑,提出了VO和XAO的解决方案,并采用了COMMAND模式进行设计实现。 相似文献
62.
63.
The role of hypoxia-inducible factors in cancer 总被引:7,自引:0,他引:7
64.
Parasites of the grey mullet Mugil cephalus collected from Lower K?z?l?rmak Delta in Turkey were investigated. Trichodina puytoraci, Trichodina lepsii, Ligophorus mediterraneus, Ligophorus cephali, Gyrodactylus sp., Microcotyle mugilis, Ascocotyle (Phagicola) longa, Haplosplanchnus pachysomus, Diplostomum spathaceum, Tylodelphys clavata, Posthodiplostomum sp., Neoechinorhyncus agilis and Ergasilus lizae were identified. Overall infection prevalence (%), mean intensity and mean abundance values were 99.61%, 458.10 ± 75.72 and 456.30 ± 75.44, respectively. Infection indices of parasite species in relation to season, lakes/lagoons and some physicochemical parameters of water such as temperature, salinity, dissolved oxygen and nitrate are determined and discussed. Posthodiplostomum sp. is a new parasite record for mugilids and Diplostomum spathaceum is the first record in M. cephalus, in the present study. Moreover, Ligophorus mediterraneus, Ligophorus cephali and Ergasilus lizae are new records for Turkish parasite fauna of fish and Mugil cephalus is a new host record for Neoechinorhyncus agilis in Turkey. 相似文献
65.
基于J2ME移动通讯设备软件的研究与开发 总被引:2,自引:0,他引:2
本文深入介绍了J2ME体系结构,分析了移动设备应用程序的结构和开发过程,讨论了将J2ME/M IDP应用程序和J2EE服务集成的方法,并预测了移动商务的前景. 相似文献
66.
67.
Shin JM Vagin O Munson K Kidd M Modlin IM Sachs G 《Cellular and molecular life sciences : CMLS》2008,65(2):264-281
Inhibition of gastric acid secretion is the mainstay of the treatment of gastroesophageal reflux disease and peptic ulceration;
therapies to inhibit acid are among the best-selling drugs worldwide. Highly effective agents targeting the histamine H2 receptor
were first identified in the 1970s. These were followed by the development of irreversible inhibitors of the parietal cell
hydrogen-potassium ATPase (the proton pump inhibitors) that inhibit acid secretion much more effectively. Reviewed here are
the chemistry, biological targets and pharmacology of these drugs, with reference to their current and evolving clinical utilities.
Future directions in the development of acid inhibitory drugs include modifications of current agents and the emergence of
a novel class of agents, the acid pump antagonists.
Received 30 May 2007; received after revision 15 August 2007; accepted 13 September 2007 相似文献
68.
Muñoz U Bartolomé F Esteras N Bermejo-Pareja F Martín-Requero A 《Cellular and molecular life sciences : CMLS》2008,65(21):3507-3519
It has been proposed that neuroinflammation, among other factors, may trigger an aberrant neuronal cell cycle re-entry leading
to neuronal death. Cell cycle disturbances are also detectable in peripheral cells from Alzheimer’s disease (AD) patients.
We previously reported that the anti-inflammatory 15- deoxy-Δ12,14-prostaglandin J
2 (15d-PGJ
2) increased the cellular content of the cyclin-dependent kinase inhibitor p27, in lymphoblasts from AD patients. This work
aimed at elucidating the mechanisms of 15d-PGJ
2-induced p27 accumulation. Phosphorylation, half-life, and the nucleo-cytoplasmic traffic of p27 protein were altered by 15d-PGJ2
by mechanisms dependent on PI3K/Akt activity. 15d-PGJ
2 prevents the calmodulin-dependent Akt overactivation in AD lymphoblasts by blocking its binding to the 85-kDa regulatory
subunit of PI3K. These effects of 15d-PGJ
2 were not mimicked by 9,10-dihydro-15-deoxy-Δ12,14- prostaglandin J
2, suggesting that 15d-PGJ
2 acts independently of peroxisome proliferator-activated receptor γ activation and that the α,β-unsaturated carbonyl group
in the cyclopentenone ring of 15d-PGJ
2 is a requisite for the observed effects.
Received 14 July 2008; received after revision 2 September 2008; accepted 12 September 2008 相似文献
69.
诗人蒲柏曾给牛顿拟过一个碑文,后来虽未予采用,但该诗却流传甚广,很多关于牛顿的文章都引用过它。其后,另一个英国诗人J.C.斯奎尔,按同样的形式又续了一首诗。对于后一首诗准确的理解和翻译,曾经引起了一场很热烈的争论。 相似文献
70.
以NaBrO3/NaHSO4.H2O为氧化体系在固态条件下,通过对二芳基卡巴肼的单侧脱氢快速高效合成了十种二芳基卡巴腙.该方法操作简便、产率高、无溶剂、对环境友好. 相似文献