6-BA、NAA及其组合对诱导薄荷茎段分化与增殖的影响

对激素6-BA，NAA及其组合诱导薄荷茎段的分化与增殖进行研究。结果表明：6-BA在0.5～5mg/L范围内有利于茎段芽的诱导，且诱导芽数随着6-BA浓度的升高而增加；NAA在0.05～lmg/L范围内苗的生长明显，且在0.05～0.3mg/L有利于根的诱导；激素组合6-BA2mg/L NAA0.1mg/L最有利于芽的诱导，增殖系数达到7.7。     

FOUNDATION OF NUCLEAR ALGEBRAIC MODELS

Based upon Tomonoga-Rowe‘s many body theory, we find that the algebraic models, including IBM and FDSM are simplest extension of Rowe-Rosensteel‘s sp(3R).Dynkin-Gruber‘s subalgebra embedding method is applied to find an appropriate algebra and it‘s reduction chains conforming to physical requirement. The separated cases sp(6) and so(8) now appear as two branches stemming from the same root D6-O(12). Transitional ease between sp(6) and so(8) is inherently include.     

Host defense against infections and inflammations: Role of the multifunctional IL-6/IFN-β2 cytokine

Summary IL-6/IFN-2 appears to be one of the important mediators of the response to viral and bacterial infections and to shock. The biological effects now associated with IL-6/IFN-2 include: stimulation of immunoglobulin secretion by mature B lymphocytes (BSF-2 activity), growth stimulation of plasmacytomas and hybridomas (HGF activity), activation of T cells, stimulation of hepatic acute phase protein synthesis (HSF activity), stimulation of hematopoiesis, cell differentiation (DIF activity), inhibition of tumor cell growth (AP activity) and other IFN-like effects. As a typical cytokine, IL-6/IFN-2 is secreted by many cell types and acts in various combinations with other interleukins and interferons.     

Novel rearrangement of purines

Summary 6-Trichloromethyl-9-methylpurine (1) rearranges to 6-dichloromethyl-9-methyl-8-oxopurine (2) in aqueous mild acidic solution. The rearrangement is rationalized in terms of a reaction involving protonation, covalent hydration, prototropic equilibrium and/or a hydride transfer. An alternative mechanism involving a positive halogen compound and hypochlorous acid as an intermediary is also proposed. Compound1 condenses with 4,5-diaminopyrimidine to give the purine-pyrimidine Schiff base pair4.Acknowledgments. We are deeply indebted to Professor S. Cohen of the Sackler School of Medicine, Tel Aviv University (Ramat Aviv, Isreal) for his advice and encouragement. Support of this research by the Israel Cancer Association, the Ber-Lamsdorf Foundation Switzerland Israel and by the Advancement of Mankind Foundation, is gratefully acknowledged. We thank Proff. D. Arigoni and A. Eschenmoser, ETH Zürich, for their valuable proposals and comments on the mechanism of the rearrangement.     

6-氮杂甾醇类Ⅱ型5-α还原酶抑制剂的三维定量构效关系研究和虚拟筛选

采用Topomer CoMFA对37个6-氮杂甾醇类抑制剂进行三维定量构效关系分析,新建模型的交互验证和拟合相关系数为q2=0.774,r2=0.965,结果表明模型具有良好的可信度和预测能力.将基于配体的Topomer search虚拟筛选、基于受体的分子对接虚拟筛选和基于3D-QSAR模型的分子活性预测等方法运用到新抑制剂的分级筛选,最终获得4个高活性的新抑制剂分子.新抑制剂的Surflex-dock结果显示6-氮杂甾醇类抑制剂与5AR-Ⅱ靶点的作用模式主要是氢键作用.MTT法生物学活性测试结果显示新抑制剂能显著抑制BPH-1细胞增殖,且抑制程度呈浓度依赖性.通过分子对接机理解释和细胞学实验的抑制前列腺增生活性测试,这两种研究方式相互验证,证明此虚拟筛选方法能够为治疗良性前列腺增生的新药设计提供有效候选化合物.     

U型调质钢滚压成型机主机方案设计

应用型材滚弯基本原理,分析U型钢的滚弯成形过程中出现的直线段的问题.在对现有的三辊、四辊成形机原理进行分析的基础上,采用六辊滚弯原理,研制出既能修复又能成形的U型调质钢滚压成形机、其技术关键在于两对动辊的综合,这种综合可通过复合机构实现.此种机构可实现修复与成形于一体 成为国内外先进的最新的机型.     

取代酚-咪唑 型环番的合成

用２，６－二（咪唑甲基）－４－氯苯酚分别与邻、间、对－二（溴甲基）苯或２，６－二（溴甲基）吡啶反应，合成了一类新型的取代酚－咪唑钅翁型环番．所有化合物均被ＭＳ，１ＨＮＭＲ，ＩＲ和元素分析证实     

1—氢—3,6—二甲氧基环丙萘的合成及表征

本文报导了用含二氯环在的化合物为原料，在强碱条件下，一步合成１－氢－３，６－二甲氧基环丙萘。     

1,2,3,6-四氢化邻苯二甲酸酐异构化反应研究

本文在气相色谱分析的基础上,研究了1,2,3,6-四氢化邻苯二甲酸酐在各种路易士酸催化下的反应情况,并对以对甲苯磺酸为催化剂的反应进程提出了通过碳正离子中间体的可能机理。