多层弹性体空间一般问题的解析解

本文利用广义柔度矩阵递推法,成功地导出了多层半无限弹性体空间一般问题,在任意荷载作用和两种层间接触条件下的通解.对于这个通解,不管弹性体的层数为多少,最后均不需再解任何联立方程.作为应用,文末计算了地基位移和应力问题实例.     

小样本参数估计算法及其应用

本文简要介绍了Minimax法和MSAR法对小样本数据的研究,随之重点介绍了1种实用的新算法IMSAR法及其应用。该法是通过变权松弛最小二乘法,确定适当的权因子来实现的。它克服了MSAR法的运算量随样本数据量增加而显著增加的突出缺点,仿真结果表明:IMSAR法具有较强的抗干扰能力,可适应于噪声分布未知的情况。最后,本文将IMSAR法应用于转炉炼钢动态模型及药物房室模型的建立,收到了令人满意的效果。     

切削刀具倒棱刃口挤压力的理论计算

根据试验观察．揭出了刀具刃口带负倒棱时的切削模型。在此模型中,刀具刃口 存在一个“金属死区”。以新模型为基础．采用能量法,对高温、高应变率下刀具刃 口的挤压力进行了理论计算。所做工作的特点是：１）在材料变形分析中计入了挤压 层金属绕过刀具刃口时的过剩变形;２）进行有关材料变形与物理特性的计算时,考 虑了温度与应变率的影响。利用新研制的压电式切削测力仪进行验证试验,其结果表 明,理论计算值与实测数据较好一致。     

空间机构的位置分析

本文以“基本方向”确定空间机构中各构件的位置,并基于“基本方向”之间的关系以及机构的环路封闭条件,建立了机构位置分析的数学模型。将优化技术和求解非线性方程组迭代技术结合起来,提高了解决问题的可靠性及效率。     

The contents of the pygidial gland of the primitive antNothomyrmecia macrops (Hymenoptera:Formicidae)

Summary The principal constituent of the pygidial gland ofNothomyrmecia macrops is 3,7-dimethyloct-6-en-2-one, a substance not previously identified in insects. Also identified were 2,6-dimethylhept-5-enal, 2-nonanone, indole, -dodecalactone, and the hydrocarbons pentadecane, heptadecane, heptadecene and heptadecadiene, all in low nanogram quantities.     

Pharmacodynamic profile of CQP 201-403, a novel 8α-amino-ergoline

Summary The profile of action in animals of CQP 201-403, a novel 8-amino-ergoline, is in most aspects that of a very potent dopaminomimetic, both as a prolactin secretion inhibitor, and at the levels of the CNS and the cardiovascular system. Qualitatively CQP 201-403 differs slightly from bromocriptine and apomorphine in its effects on the CNS (no influence on serotonin metabolism in the rat cortex; induction of masculine mounting behavior in rats) and the cardiovascular system of the dog (reflex tachycardia in response to a blood-pressure fall). In man the new compound proved to be highly active in lowering prolactin serum levels and to be more potent than bromocriptine (Parlodel^®).In memory of Dr Annemarie Closse, who died 14 June 1987.     

Proopiomelanocortin expression in the skin during induced hair growth in mice

We demonstrate for the first time a hair cycle-dependent gene and protein expression of proopiomelanocortin in mouse skin in vivo. Northern blot detected POMC mRNA with an apparent size of 0.9 kb in anagen but not telogen skin. Western blot emphasized a specific protein of 30–33 kDa recognized by anti -endorphin in late but not early anagen or telogen skin. By immunocytochemistry, -endorphin antigen was localized in the sebaceous gland in a hair cycle dependent manner.     

Preferential excretion of glycated albumin in C57BL-Ks-J mice: Effects of diabetes

Urinary excretion of glycated albumin was quantitated in genetically hyperglycemic mice (C57BL-Ks-J, db/db mice), a model for non-insulin-dependent diabetes mellitus, and compared with their non-diabetic littermates. The data indicated a preferential excretion of glycated albumin in non-diabetic mice. This phenomenon of editing of glycated albumin is decreased significantly in diabetic mice. Quantitative measurements of overall excretion of glycated albumin suggested that the loss of editing in diabetic mice is due to the dilution of glycated albumin by the unmodified albumin which is excreted in large amounts in diabetic mice. Therefore, the loss of editing observed in this model resembled the one we characterized in insulin-dependent diabetic humans and a streptozotocin-diabetic rat model³.     

Purification of platelet-derived endothelial cell growth inhibitor and its characterization as transforming growth factor-β type 1

In 1986, Brown and Clemmons (Proc. natl Acad. Sci. USA83 (1986) 3321) showed that platelets contain a substance, platelet-derived growth inhibitor (PDGI), that inhibits in vitro endothelial cell replication. Although platelets are rich in transforming grwoth factor (TGF-), PDGI was considered not to be related to TGF-, on the basis of its reported properties (extraction from platelets at neutral pH, binding to heparin-Sepharose). However, we purified PDGI to near homogeneity and showed that on the basis of HPLC retention behavior, in vitro growth inhibitory activities with several cell types, receptor binding, and immunoneutralization of growth inhibitory activity with specific anti-TGF- type 1 antibodies, PDGI is most probably identical with TGF- type 1.