Early circulating erythroid progenitors (BFU-E) in sickle cell anemia

Sickle cell anemia (SS) patients can be divided into two sub-populations according to peripheral HbF levels. Patients with low (<9%) HbF levels (LFSS) are characterized by an increased number of circulating BFU-E in active DNA synthesis, and release of burst promoting activity (BPA) by unstimulated low density (LD) adherent cells. In contrast, circulating BFU-E from SS patients with high (>9%) HbF levels (HFSS) are normal in number, largely in resting phase, and their LD cells do not release BPA-like activity.More recently further heterogeneity has been found among these two groups. In LFSS patients GM-CSF is constitutively produced by unstimulated monocytes. In contrast, HFSS patients' adherent cell depletion increases cycling of BFU-E in culture. CM from HFSS patients inhibits BFU-E expression in culture. Hence, LD adherent cells from HFSS patients may release an inhibitory factor(s). The nature of this factor has to be determined.In addition, there are distinct subpopulations of BFU-E responsiveness to growth factor (GM-CSF, IL-3): a) LFSS patients have a homogeneous BFU-E population, equally responsive to GM-CSF and IL-3; b) HFSS patients, in addition to this subpopulation, have a subset of BFU-E dependent exclusively on IL-3 which is 20 to 40% of the total number of circulating BFU-E. This is similar to BFU-E from normal individuals. Hence, LFSS BFU-E represent an actively proliferating population, equally responsive to GM-CSF and IL-3, controlled by at least constitutively produced GM-CSF and possibly other factors.These observations suggest a significant modification in BFU-E behavior in the subset of SS patients with low HbF levels and high hemopoietic stress. The heterogenous regulation of BFU-E in SS disease seems to be an epiphenomenon of HbF levels, and not vice-versa.     

基于PIC单片机和ICL7650的高性能检流计

本文阐述了基于PIC单片机和ICL7650的指针式检流计的设计,实现了表头指针保护,欠压检测,自动关机,键控灵敏度选择等功能并具有稳定性和灵敏度高的性能。     

国内外脂肪代用品的研究

脂肪代用品在替代食品中的脂肪并模拟其性能,维护消费者身心健康方面起着重要的作用,在对国内外脂肪代用品的研究现状综述的基础上,指出了我国脂肪代用品的研究前景。     

关于ln2的渐近展开公式

通过引进变量代换和级数求和法得到ｌｎ２的若干新的渐近展开式，并且比较了计算ｌｎ２的收敛速度。所得结果有利于计算和判断收敛速度，对估计ｌｎ２近似计算中的误差提供了依据。     

有关亲核取代反应和β—消去反应的教学思考

卤代烃化学性质的教学是该章节的重点和难点.从基本概念入手,通过对两类反应机理和影响因素的讲解,可以让学生较为轻松地突破难点,将α—C设计在一个假想平面上讲解亲核取代和消去反应机理,方便学生对亲核取代和消去反应机理和有关立体化学的理解和掌握.     

基于DS18B20的数字式测温计设计

讨论了用C8051F320单片机和DS18B20单总线数字测温传感器,来设计数字式测温计的方法.完全利用单总线技术线路简单、硬件开销少、成本低廉、软件设计简单的优点,较好地解决了传统测温仪器普遍存在的携带不便、易损坏、易受腐蚀、易受电磁干扰等不足.可应用于对温度测量要求高可靠度、高精度、高智能化的HVAC环境控制等领域.     

企业电能管理系统的通信研究

通信层是企业电能管理系统必不可少的组成部分,本项目采用TI公司的TMS320F2812 DSP作为通信终端主芯片,传输网采用RS485总线手拉手布网并采用广播应答通信方式,设计电路板和布网时应用抗干扰技术保证通信质量,考虑到未来系统的发展选用Modbus通信规约方便日后与外界相连网.     

FINITE RIODAN MATRIX AND RIODAN GROUP

l introductionIn 1991, L. Shapiro and his co -- authorsI2] gave the following.Definition l.l Let L = (l.i),.j >0 be a infinite matrix with entries that belong to the fieldC of complex numbers, and letbe the GF of the i,, column of L. Then L is called a Riodan matrix ifwb e reandsuch that g(x) and f(x) belong to the ring of formal power series C[x] and f, /0.The Riodan matrix has many applications to combinatoricsll]--14]. For example, in 1997,N. Asamoah[I] dealt with the problem of latt…     

Y型沸石分子筛羟基谱带的红外光谱研究

本文制备了一系列不同硅铝比的Y型沸石样品,以红外光谱法系统地研究了样品的羟基谱带及其变化情况。结果表明,Y型沸石羟基谱带随沸石体系组成的变化及晶格空位和骨架外铝的出现而发生一系列的变化,样品表面羟基振动频率受骨架内电负性和骨架外电荷变化的影响会产生规律性的位移,进一步还讨论了其作用的机理,另外讨论和归属了Y型沸石常出现的几种羟基红外吸收谱带。     

离子取代对La_2CuO_4的结构和磁学性质的影响(英文)

La2 CuO4的结构中因存在键角为 180°的…Cu—O—Cu—O—Cu…链而表现出反铁磁性 .Zn2 + 或Mg2 + 取代Cu2 + 后就破坏了这种长程有序 ,使Cu2 + 的有效磁矩升高 ,并且在 77～ 30 0K温区内观察不到N啨ｅｌ态 .La2 Cu1 xNixO4没有电子自旋共振(ESR)响应 ,也观察不到其N啨ｅｌ态 .La2 Cu1 xMxO4(M =Zn2 + ,Mg2 + )有ESR响应 ,这种响应很可能是由拉长的CuO6 八面体产生的 .采用常规的物理方法如X 射线粉末衍射 (XRD)和电子自旋共振等对样品进行了表征