灼口综合症的神经心理学机制研究

灼口综合症属于口腔粘膜的慢性疼痛疾病,其病因尚不清楚.从神经心理学这一新的视角对此病的发病机制加以论述.     

血虚证动物模型的标准化研究初探

目的建立标准化的血虚证动物模型。方法采用慢性失血法、溶血法和骨髓抑制法制造三种血虚证模型,观察一般情况和与血发生有关的实验室指标,并用四物汤反证造摸效果。结果三种动物模型均符合血虚证表现,同时出现外周血、骨髓有核细胞数目和细胞周期的改变,四物汤对三种动物模型均有一定疗效。结论建立了三种符合标准化的血虚证模型。     

54例2型糖尿病并高压病的临床分析

为弄清2型糖尿病并高血压病的临床特点,提高其防治水平,对54例2型糖尿病并高血压病的临床资料进行了回顾性分析。结果表明,2型糖尿病并高血压病可同时或相继发生,而且具备以下特点：嗜咽酒,高热量饮食,体力活动力,肥胖超重,血脂异常,年龄高;胰岛素抵抗综合征是2型糖尿病并高血压病共同的环境背景和发病机制,通过生活调节及药物干预,可防止病情的发展,降低死亡率。     

祛寒逐风合剂治 疗尢 王痹(类风湿性关节炎)的研究

祛寒逐风合剂是以1972年由甘肃武威出土的汉代医简中“伤寒逐风方”为基础方配制而成的中药制剂,供临床使用。方中有制附片、川椒、细辛、白术、川芎、制鳖甲等,以温经散寒为主,佐以祛风除湿、活血止痛、补益肝肾,尊《黄帝内经》中“寒者热之”、“治寒以热”之大法,主要用于治疗wang痹（类风湿性关节炎）之辩证为风寒湿阻者。几年来临床观察120例,其中治愈23例,好转95例,临床验证取得了满意疗效,与宝光牌风湿液治病该病作对照,其疗效结果经统计学处理,治疗组优于对照组（P＜0．01）,且该药对中医辩证为风寒湿阻之各种痹证,包括西医诊断之风湿性关节炎、类风湿性关节炎、强直性脊柱炎、增生性关节炎、各种腰腿痛等都有很好的疗效,有望成为治疗风湿病的一种有效药物。     

猪断奶后多系统衰弱综合征的病原学分析和诊断

断奶后多系统衰弱综合征是由猪环状病毒 2型 (PCV2 )引起的 ,PCV2属于环状病毒属 ,它是一小的、无囊膜、环形、单股、负链DNA病毒。PCV 2各分离株的同源性可达 95 %— 99% ,世界范围内只有一个PCV2血清型。诊断此病除依据临床症状与病理变化外 ,还利用中和试验、间接免疫荧光法和抗原捕捉酶免疫法检测抗体。组织化学法检测抗原 ,原位杂交及聚合酶链技术检测病毒DNA。注重日常管理和环境条件的控制 ,将此病给养猪业造成的损失减至最小。     

How do Shp2 mutations that oppositely influence its biochemical activity result in syndromes with overlapping symptoms?

Activating and inactivating mutations of SHP-2 are responsible, respectively, for the Noonan (NS) and the LEOPARD (LS) syndromes. Clinically, these developmental disorders overlap greatly, resulting in the apparent paradox of similar diseases caused by mutations that oppositely influence SHP-2 phosphatase activity. While the mechanisms remain unclear, recent functional analysis of SHP-2, along with the identification of other genes involved in NS and in other related syndromes (neurofibromatosis-1, Costello and cardio-facio-cutaneous syndromes), strongly suggest that Ras/MAPK represents the major signaling pathway deregulated by SHP-2 mutants. We discuss the idea that, with the exception of LS mutations that have been shown to exert a dominant negative effect, all disease-causing mutations involved in Ras/MAPK-mediated signaling, including SHP-2, might lead to enhanced MAPK activation. This suggests that a narrow range of MAPK signaling is required for appropriate development. We also discuss the possibility that LS mutations may not simply exhibit dominant negative activity. Received 30 November 2006; received after revision 8 February 2007; accepted 13 March 2007     

The molecular role of the Rothmund-Thomson-, RAPADILINO- and Baller-Gerold-gene product, RECQL4: recent progress

The RecQ family of DNA helicases is highly conserved throughout evolution and plays an important role in the maintenance of genomic stability in all organisms. Mutations in three of the five known family members in humans, BLM, WRN and RECQL4, give rise to disorders that are characterized by predisposition to cancer and premature aging, emphasizing the importance of studying the RecQ proteins and their cellular activities. Interestingly, three autosomal recessive disorders have been associated with mutations in the RECQL4 gene: Rothmund-Thomson, RAPADILINO, and Baller-Gerold syndromes, thus making RECQL4 unique within the RecQ family of DNA helicases. To date, however, the molecular function of RECQL4 and the possible cellular pathways in which it is involved remain poorly understood. Here, we present an overview of recent findings in connection with RECQL4 and try to highlight different directions the field could head, helping to clarify the role of RECQL4 in preventing tumorigenesis and maintenance of genome integrity in humans. Received 31 October 2006; received after revision 4 January 2007; accepted 5 February 2007     

Chronobiology of sleep in humans

Periodic circadian (24-h) cycles play an important role in daily hormonal and behavioural rhythms. Usually our sleep/wake cycle, temperature and melatonin rhythms are internally synchronized with a stable phase relationship. When there is a desynchrony between the sleep/wake cycle and circadian rhythm, sleep disorders such as advanced and delayed sleep phase syndrome can arise as well as transient chronobiologic disturbances, for example from jet lag and shift work. Appropriately timed bright light is effective in re-timing the circadian rhythm and sleep pattern to a more desired time, ameliorating these disturbances. Other less potent retiming effects may also be obtained from the judicious use of melatonin and exercise.     

融合知识图谱的多通道中医辨证模型

中医辨证是中医临床立法、处方、用药的基础和前提。中医电子病历缺乏高质量语料,模型训练容易欠拟合,且四诊信息的症状表达形式存在较大差异,限制了网络模型对复杂症状的识别能力。针对上述问题,通过对四诊信息多通道的分开处理,以及人工构建的小规模知识图谱对模型训练进行知识的增强,提出了融合知识图谱的多通道中医辨证模型。实验结果表明,基于中医电子病历数据集,提出的模型在P@1指标、P@3指标、P@5指标上相比基线模型分别提高3.51%、3.38%、3.32%,相比其他网络结构模型也有不同程度的提高,验证了所提模型对中医辨证具有显著效果。     

基于粗糙集理论的中医方证相关性算法的研究

方证相关性问题是中医理论中的重要问题之一,是关系中医辨证论治和诊治方法现代化的重要课题.基于粗糙集理论的中医方证相关性算法研究,借助粗糙集处理模糊和不确定知识的强大功能,在现有病例集上建立知识表达系统并进行约简,求出属性核及相关支持度,进而揭示方证的相关性.本研究是对中医理论现代化的一种探索与尝试.