Molecular mechanisms of serpin deficiencies

The study of serpin deficiency is currently one of the most active areas in basic medical research. Recently, three hypotheses concerning serpin deficiency have been proposed, which are referred to as the conformational disturbance hypothesis (CDH) , loop-sheet polymerisation hypothesis (LSPH) and multiple binding site hypothesis (MB-SH) . CDH was put forward to explicit serpin deficiency due to conformational change of reactive loop of serpins as a result of mutations occurring away from the reactive site residues and LSPH was to explain deficient serpins due to the formation of polymers. MBSH was proposed to explain the mechanism of the formation of stable enzyme-serpin complex via more than one binding site and blockage or mutation in any of the sites resulting in serpin deficiency. A combination of these mechanisms may be critical in understanding the roles of the many documented mutations and autoimmunities which result in qualitative and quantitative serpin deficiency.     

基于小波滤波及载噪比估计的GPS接收机多径抑制

为了抑制城市环境GPS(global positioning system)导航应用中由复杂信号反射引起的多径效应,提出了一种基于假设检验小波阈值滤波处理并联合载噪比估计的GPS接收机多径抑制方法.这种方法作用于GPS导航接收机的码和载波跟踪环路,通过估计由多径引起的跟踪误差,补偿伪距估计量,进而消除多径效应引起的定位误差.仿真实验结果表明,对于城市环境典型导航应用的多径场景,所提出的方法显著改善用户定位精度,能够将定位误差从标准接收机处理下的15.95 m降至1.75 m,而计算量无明显增加.     

基于Hellinger距离的连续型总体的假设检验

研究了两个连续型总体参数的假设检验问题.基于Hellinger距离和参数的最大似然估计,建立了一个检验统计量.在一定条件下,证明了所建立的统计量渐近服从自由度为1的卡方分布.最后用随机模拟的方法研究了所建立的统计量的稳健性,并且与似然比检验作了比较.     

论朱德对丰富毛泽东建党思想的若干思考——纪念建党90周年

目前,朱德建党思想研究多从廉政视角展开,而将其作为独立研究领域进行宏观考察的相对较少,尚需深挖和进行理论规整。朱德作为老一辈无产阶级政党领袖,在革命、建设中对党的建设进行了许多深入思考,有着特色的表述方式:站在"科学最高成就"的高度认识马克主义理论指导地位,倡导理论学习与指导的"一贯性"与"发展性";以"站在群众之中"的政党建设根本利益观作为尺度,倡导党的群众利益观;把发展作为恒久命题,倡导党应领导建立"革命家务"和搞好建设;把干部发展作为主线,倡导人才选拔"眼光向下"、青年成长重在学习。     

两参数指数—威布尔分布模型多重模糊假设检验的贝叶斯方法

针对两参数指数—威布尔分布模型,对特定的损失函数,选取Jeffreys和共轭先验分布,研究了精确样本和模糊样本的多重模糊假设检验的贝叶斯方法,并给出了数值算例.     

英语四级机考对大学英语教学模式的启示

大学英语四级机考的新模式有利于促进新的大学英语教学模式的形成。在新的教学理念指导下,通过积极开发课程资源,加强真实语言文化信息输入,大学生的英语实际应用能力,特别是英语听说能力将得到进一步的增强。     

都是“时间”惹的祸——科学探究教学中由提出假设到验证假设

从小学科学探究教学中存在的实际问题——教师经常因为"时间不够"而排除学生的多种假设,只验证其中的一、两种来进行科学探究的情况出发,结合科学史中科学家进行科学探究的过程,分析此种现象给学生带来的影响,剖析其产生的原因,提出适当建议.以期对新课改以来的小学科学探究教学有所裨益.     

Risk premia and long rates in Ireland

Using a number of long‐term maturities and monthly data, 1989–1997, we provide a number of tests of the expectations hypothesis (EH) of the term structure. The main insight in this paper is the use of the excess holding period return to provide a proxy for a possible time‐varying term premium. Nearly all previous studies using the VAR methodology have used only the spread and the change in (short) rates and they have ignored the excess holding period return. We find that we cannot reject the EH, but we do reject the presence of time‐varying risk premia. Copyright © 2001 John Wiley & Sons, Ltd.     

度量空间中某类泛函极小的Hlder连续性

主要研究了牛顿空间中泛函F(u,gu)=∫f(u,gu)dμ的极小问题,其中对某常数c>0,泛函满足gup-c|u|p≤f(u,gu)≤gpu+c|u|p.牛顿空间是Sobolev空间在度是空间中的推广,具有更一般的性质.在该空间中研究偏微分方程,对建立更一般的偏微分方程理论具有指导和开拓意义.本文利用De Giorgi迭代的方法研究了该泛函极小的正则性,证明了该泛函极小的Hlder连续性.这使得我们在不求精确解的情况下,利用方程本身的条件可以对方程解进行数值估计.     

Anurans of a seasonally dry tropical forest: Morro do Diabo State Park,São Paulo state,Brazil

We studied the richness and composition of the anuran assemblage of Morro do Diabo State Park, the major remnant of Mesophytic Semideciduous Forest in the state of São Paulo, Brazil, through hypothesis tests. From September 2005 to March 2007 we recorded 28 anuran species, comprising a mix of Atlantic, Cerrado and South American widespread species, usually considered tolerant to anthropic modifications. The low richness of species and reproductive modes, the predominance of habitat generalist species, and the high similarity with Cerrado areas can be explained by the climatic seasonality of the studied area (a pronounced dry season), as well as its large distance from centres of anuran diversification, such as the coastal mountains of the wet Atlantic Forest.