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101.
Summary Visual determination of MSH-induced pigment migration in melanophores of small pieces ofAnolis carolinensis skin is standardized by first measuring photoelectrometrically the change in reflection/transmission of the whole dorsal skin in response to different hormone concentrations. This method allows the rapid and precise recording of time-response curves after photoaffinity labeling of MSH receptors or of dose-response curves of large series of synthetic compounds.Acknowledgments. We wish to thank Ms V. Jäggin, Ms C. Schulthess and Ms G. van Hees for excellent technical assistance, Dr. R. Andreatta, Ciba-Geigy AG, Basel, for his generous gift of -MSH and Prof. A Pletscher for his continuous interest. This work was supported by the Swiss National Science Foundation. 相似文献
102.
N. Akaike K. Hattori Y. Oomura D. O. Carpenter 《Cellular and molecular life sciences : CMLS》1985,41(1):70-71
Summary Using isolated, internally perfused bullfrog dorsal root ganglion cells we have studied the dose-response curves for -aminobutyric acid (GABA) in the presence of internally or externally applied GABA antagonists. With external application of antagonists the inhibition of the GABA current by bicuculline was competitive and that by picrotoxin was noncompetitive. Picrotoxin but not bicuculline blocked when internally perfused.To whom reprint requests should be addressed.Acknowledgments. We thank Drs S. Minakami and S. Yasui for helpful discussions and comments. 相似文献
103.
Summary Glucose-6-phosphate dehydrogenase and N-acetyl--glucosaminidase activities were both elevated after eccentric exercise indicating that this type of exercise causes muscle damage. Muscle damage as measured by glucose-6-phosphate dehydrogenase activity in the vastus intermedius was greater and occurred later in larger rats indicating that the susceptibility to muscle damage is increased and the repair process delayed in older and larger animals. 相似文献
104.
105.
S. J. Arnold 《Cellular and molecular life sciences : CMLS》1985,41(10):1296-1310
Summary Quantitative genetic models of sexual selection have disporven some of the central tenets of both the handicap mechanism and the sexy son hypothesis. These results suggest that the good genes approach to sexual selection may generally lead to erroneous results.Runaway sexual selection seems possible under a wide variety of circumstances. Quantittive genetic models have revealed runaway processes for sexually selected attributes expressed in both sexes and for attributes of parental care. Furthermore, the runaway could occur simultaneously in a series of populations that straddle an environmental gradient. While the models support the feasibility of runaway processes, empirical studies are needed to evaluate whether runaways actually happen. Estimates of critical genetic parameters are particularly needed, as well as measures of natural and sexual selection acting on the same population.The models also show that sexual selection has tremendous potential to produce population differentiation, particularly in epigamic traits. Differentiation is promoted by indeterminancy of evolutionary outcome, transient differences among populations during the final slow approach to equilibrium, sampling drift among equilibrium populations, and the tendency of sexual selection to amplify geographic variation arising from spatial differences in natural selection. Recent work with two- and three-locus models of sexual selection has produced results that parallel the results of the polygenic models36–38,58. Thus the feature of indeterminate equilibria (outcome dependent on initial conditions) is common to both types of model. 相似文献
106.
R. K. A. Giger H. R. Loosli M. D. Walkinshaw B. J. Clark J. M. Vigouret 《Cellular and molecular life sciences : CMLS》1987,43(10):1125-1130
Summary We report the synthesis, stereochemistry and preliminary pharmacological evaluation of DCN 203-922, a novel ergot alkaloid of the cyclol type, which contains in its peptide moiety the uncommon amino acid L-allo-isoleucine.Part of this paper was reported by this author at the Herbstversammlung der Schweizerischen Chemischen Gesellschaft, Bern, in October 1986. 相似文献
107.
S. Burstein S. A. Hunter V. Latham L. Renzulli 《Cellular and molecular life sciences : CMLS》1987,43(4):402-403
Summary The results described here demonstrate that THC-induced catalepsy in mice can be substantially inhibited by the prior administration of 1-THC-7-oic acid, the major metabolite of THC in most species including humans. This raises the possibility that the intensity and duration of action of THC may depend to a large degree on the levels of this metabolite at the sites of action.We thank the National Institute on Drug Abuse for supporting this project by grants DA-02043 and DA-02052 and for supplying all of the cannabinoids. One of us (S.B.) is also the recipient of a Research Scientist Award from NIDA. We are grateful to Kristen Carlson and Thomas Honeyman for helpful suggestions in preparing this report. 相似文献
108.
数字式仪表常用于变电站、工厂等生产环境,是一种直观的设备监测仪器。然而当前数字式仪表的读取方式还依赖于人工巡检,手动记录等,这些传统的巡检方式来监测设备的运行状态大大降低了巡检效率。为了实现传统行业的数字化转型,本文提出基于轻量化深度学习的数字仪表识别方法,通过改进的YOLOv5的目标检测框架,针对数字仪表目标区域在整张图片大小不一致的情况,提出对于感兴趣区域(ROI)的迭代目标检测方法,首次检测将感兴趣区域进行检测并切割统一到相同的尺度,随后迭代检测网络针对感兴趣区域内的字符进行检测并分类,以达到精确读数的目的。为提升多尺度检测性能,本文采用Res2Net模块主干网络中的的残差模块。采用GIoU取代通用的IoU作为位置损失函数加速模型训练效果的收敛。实验表明,改进后的框架实现了99.62%的准确率和99.55%的召回率,相比基线网络分别提升了12.72%和5.85%。通过将框架在边缘计算平台上的终端部署,在实际生产中取代了人工巡检,实现了商业化运行。 相似文献
109.
长7储层是鄂尔多斯盆地主要的致密区块,近一半的致密油分布其中。针对长7储层开采渗透率低、开采难度大、依靠弹性开采产能较低、能量衰竭较快等问题,通过数值模拟的方法,构建水平井分段压裂数值模拟模型,首先对比不同吞吐方式对油田产能的影响,优选出CO2吞吐为首选的补充能量方式。其次对井网形式、井网参数及吞吐参数进行优化研究。最终优选出合适的吞吐方案,达到提高生产效率的目的。结果表明,该储层的最优注采吞吐参数为:周期注入量为2 673 t、注入压力为21 MPa、注入速度为90 t/d、焖井时间为10 d。研究对鄂尔多斯盆地长7储层提高采收率具有一定的参考意义。 相似文献
110.
针对遥感图像中飞机检测尺寸大小不一、背景复杂导致的难以识别问题,提出一种基于YOLOv5网络模型的改进方法。首先,在YOLOv5网络模型中融入Swin-Transformer模块,使网络全局建模并使全维度信息交互,以提升网络的特征提取能力;其次,对损失函数进行优化,引入SIOU损失函数以考虑真实框和预测框之间的向量角度问题。对比实验表明,优化前后网络模型检测精度均为95.3%。在检测精度相同的情况下,改进后的网络模型召回率为91.2%,比改进前提升0.6个百分点;改进后平均检测精度mAP0.5为95.7%,比改进前提升0.2个百分点。结果表明,改进后的YOLOv5网络模型能在一定程度上提升遥感图像中飞机目标检测性能。 相似文献