AR(p)扰动下最小均方误差受控过程的联合监控

针对最小均方误差(Minimum Mean Square Error,MMSE)受控过程联合监控可控输入与过程输出这一问题,在任意阶自回归AR(p)平稳扰动模型下开发了一种通用的联合控制图,并将界内点排列非随机判异规则引入其中.同时,对AR(p)平稳扰动模型下生产过程的MMSE控制器和输入与输出的平均链长(Average Run Length,ARL)进行了推导.最后,通过仿真实验验证了该联合控制图的有效性.     

基于贪婪算法获取稀疏表示探讨研究

本文给出一个反例,指出在一般的字典中,稀疏表示中正交匹配搜索（OMP）算法不能得到测量的最稀疏信号,从而说明匹配搜索、正交匹配搜索等贪婪算法在稀疏表示中不能保证每一个测量能得到信号的最稀疏表示.     

制备(R)-2,2-二甲基四氢噻唑4-羧酸-L-酒石酸盐的新方法

发展了一种制备(R)-2,2-二甲基四氢噻唑4-羧酸-L-酒石酸盐(D-DMT·L-TA)的新方法,可以以73.0%的收率以及99%的光学纯度得到产品.     

邻苯二甲酸二丁酯致小鼠卵巢毒性的实验研究

目的:探讨邻苯二甲酸二丁酯对小鼠卵巢的影响及其机制.方法:320只小鼠分别灌胃不同剂量的邻苯二甲酸二丁酯(DBP)(0,100,250,500 mg/(kg·d))30天,在5 d,10 d,20 d,30 d时用分光光度法检测小鼠卵巢超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、碱性磷酸酶(AKP)和酸性磷酸酶(ACP)的活性及丙二醛(MDA)的含量,用免疫组织化学法检测卵巢Bax蛋白的表达情况.结果:DBP降低了SOD、CAT、AKP、ACP的活性,增加了MDA的含量和Bax蛋白的表达.双因素方差分析表明,剂量因素对结果的影响大于时间因素.结论:DBP促进了细胞凋亡,抑制了卵巢的抗氧化能力.     

基于CT影像的颈动脉分叉血流动力学特性分析

利用实际病人的CT影像数据构建颈动脉分叉血管几何模型,利用ANSYS有限元软件计算血流速度和压力分布,对颈动脉血流动力学的特征进行分析,如颈动脉剪切应力在一个心动周期里不同时刻的变化情况,颈动脉窦部的血流速度场随时间变化情况,涡流形成的特点;然后分析颈总动脉、颈内动脉和颈外动脉的血流阻力变化情况.数值仿真结果表明,在心动周期的不同时刻,颈动脉窦部的剪切力几乎是最小的.在颈动脉窦部下方附近,涡流易于形成.在收缩期的开始阶段,动脉阻力有一个很大的高峰.这些特点会对研究颈动脉血管疾病有一定的启发.     

Characterization of cocrystals formed by grinding amino acids through terahertz time-domain spectroscopy

In this paper,we used terahertz time-domain spectroscopy(THz-TDS)over a range of 0.3–2.5 THz to investigate the formation of solid-state cocrystals of amino acids,formed by grinding mixtures of two different kinds of amino acids.For comparison,we prepared dual-layer samples,combined by pressing two single-component pellets together without grinding.In the ground-mixture samples,some extra absorption peaks appeared,different from the characteristic peaks of the pure components,but these peaks did not appear in the dual-layer samples.Thus,these extra absorption peaks in the THz range are unique features of cocrystals.From our results,we believe that THz-TDS is a promising technique to characterize cocrystals.     

半严格-（B,G）-半预不变凸函数的性质与应用研究

主要研究了半严格-（B,G）-半预不变凸函数的性质与应用,首先通过举例子来说明半严格-（B,G）-半预不变凸函数的存在性且区别于半严格-G-半预不变凸函数、G半预不变凸函数、半严格-G预不变凸函数与严格-（B,G）-半预不变凸函数;然后给出了半严格-（B,G）-半预不变凸性的一些基本性质;最后分别在无约束与不等式约束下,获得了两类半严格-（B,G）-半预不变凸规划问题解的最优性结果。     

Isolation and characterization of rl（t）, a gene that controls leaf rolling in rice

Moderate leaf rolling is one of the most important morphological traits in rice breeding for plant ideotype. Previous studies have shown that the rl（t） gene has a high breeding potential for developing hybrid-rice varieties with an ideal ideotype, because it leads to an appropriate leaf rolling index （LRI） of about 30 % in the heterozygous state, and had a positive effect on grain yield. In this study, we isolated rl（t） and performed a preliminary investigation of its function in regulating leaf rolling in rice. DNA sequencing identified a single base change （G to T） in the finely mapped region （11 kb） containing rl（t）, and this is located in 3′-untranslated region （3′-UTR） of the only predicted gene, Roc5 （Rice outermost cell-specific）. The expression level of Roc5 is significantly higher in the rl（t） mutant than in the wild-type. Using RNAi and overexpression analysis, we found that the expression level of Roc5 correlated with LRI and leaf bulliform area, and wasalso associated with leaf abaxial or adaxial rolling. These results confirmed that Roc5 controls leaf rolling in a dosagedependent manner. Bioinformatics analysis revealed a conserved 17-nt sequence （called the GU-rich element） in the 3′-UTR of HD-GL2 （Homeodomain-Glabra2） family genes including Roc5. Based on the model of this element in regulating mRNA stability in mammals, we speculate that the single nucleotide change in this element accounts for the higher expression level of Roc5 in the rl（t） mutant compared to the wild-type, which ultimately leads to adaxial rolling of the leaf. This discovery further enhances our knowledge of the molecular mechanisms underlying leaf rolling in rice.     

Finite element models and molecular dynamic simulations for studying the response of mast cell under mechanical activation

In micropipette aspiration experiment, increasing mechanical stress applied to cell membrane induced degranulation of mast cell as well as a current that could be inhibited by an inhibitor, which is specific for the transient receptor potential vanilloid （TRPVs） channels. To determine the sensitivity of TRPVs to membrane strain and tension, and to gain new insights into the activation mechanism of TRPVs, finite element models of mast cell and molecular dynamic simulations of human aquaporin-1 are presented. During the finite element simulations, the cell membrane sustained to micropipette aspiration was simulated, and the strain distribution along membrane thickness direction was obtained. Besides, combining the finite element models of osteoblast aspirated into micro- pipette and other compared models, we examined the relationship between cell mechanical stimulations and mechanical attributes and presented a new perspective to determine the cell equivalent elastic modulus. Consid- ering the indetermination of TRPV crystal structure, human aquaporin-1, one kind of the channel membrane proteins, substituting for TRPV, has been studied with molecular dynamic （MD） simulations, under different external lateral tensions which have been obtained in mast cell finite ele- ment simulations, to investigate the mechanical stimulation effects on the membrane channels. The simulations show that human aquaporin-1 undergoes significant conforma- tional change and expands in accordance with lateraltension, which not only confirms the tendency of the pre- vious electrophysiological experiments but also leads us to a better understanding of TRPVs. The multi-scale study combining finite element simulation and MD simulation is a significant breakthrough in the field of mechanical mechanism in cell system.     

镍基催化剂对乙烷氧化脱氢制乙烯性能的研究

用均匀沉淀法制备了片状复合氧化镍NiMO(M=Li,Sr,Y,Fe,La)催化剂,并研究了其对乙烷氧化脱氢制乙烯的催化性能.采用X射线衍射(XRD)、扫描电子显微镜(SEM)、程序升温还原(H2-TPR)和程序升温脱附(O2-TPD)等方法对镍基催化剂进行了表征.X射线衍射和扫描电子显微镜检测结果表明:助剂的加入对催化剂的形貌影响不大,仍为片状结构;平均粒径为5~10 nm.程序升温还原和脱附表征结果表明:助剂Li,Sr并未进入NiO晶格;而助剂Y,Fe,La与Ni之间具有相互作用,因而影响催化剂的理化性质和催化活性.其中,Fe掺杂的片状氧化镍催化剂对乙烯的选择性和收率均有所改善,340℃时NiFeO催化剂上的乙烯收率可达18.2%.