Tussah Silk Fibroin Porous Scaffolds Prepared with a Mild Self-assembly Process for Controlled Drug Release

Besides excellent biodegradability and biocompatibility,a useful tissue engineering scaffold should provide favorable surface properties,outstanding mechanical strength and controlled drug release property. In this paper,a mild process to prepare porous tussah silk fibroin（ TSF） scaffolds from aqueous solution was described. The n-butanol was used to control the self-assembly of tussah silk. The scaffolds with different TSF concentrations and the same volume showed differences in pore size and distribution. The maximum porosity of the poprepared porous scaffolds was 80% in this paper. And the pore size of the prepared porous scaffolds with different concentrations was between 10μm and 230 μm. X-ray diffraction（ XRD） analysis revealed that amorphous TSF was crystallized to β-sheet secondary structure upon gelatin. The TSF scaffolds for controlled drug release was studied and the result showed that the time of drug release was significantly longer. The produced TSF scaffolds with sustained drug release have potential application in tissue engineering.     

赤霉素对'大富贵'芍药休眠解除及内源激素和糖类代谢的影响

研究不同质量浓度赤霉素（GA₃，0、100、200、300、1 000 mg/L）替代低温解除芍药品种‘大富贵’休眠的效果，探讨休眠解除前后其内源激素和糖类代谢生理变化，为生产上利用GA₃解除芍药休眠及调控花期提供理论及技术支撑。     

盐酸环丙沙星/二氧化硅复合粒子的原位制备及其缓释性能

利用硅酸钠在盐酸环丙沙星的酸溶液中的原位水解成功制备了盐酸环丙沙星/二氧化硅复合粒子。对所得产品进行的SEM、TEM、粒度分布、XRD和FTIR等分析表明,盐酸环丙沙星/二氧化硅复合粒子为粒径0.3～0.7μm的球形粒子,呈无定形态,且盐酸环丙沙星与二氧化硅以物理方式结合。热重分析结果表明,所得复合粒子药物负载量约为28.8％(质量分数)。体外溶出实验证明,产品具有良好的缓释性能,药物释放主要受扩散控制,具有均匀的释放速率和持久的缓释时间。     

基于AT89S52玻尔兹曼常数测量仪的设计

应用PN结电流电压特性关系,采用硅三板管接成共基极电路,由集成运放实现电流电压转换以实现弱电流测量．利用AT89S52单片机所具有的智能测控特点,由AD转换对数据进行采样,采用最小二乘法对数据进行处理,从而较准确测定玻尔兹曼常[k=0．41-1．44）×10^-23J／K],误差小于5％．测量仪有手动、半自动及自动测量三种模式．     

聚丙烯酸钠高吸水树脂合成及尿素控释性研究

利用新型交联剂制备了聚丙烯酸钠高吸水性树脂,研究考察了交联剂种类及用量、引发剂用量、丙烯酸中和度以及反应时间等因素对高吸水性树脂溶胀率及溶解率的影响,得到了制备高溶胀率、低溶解率产物的最佳反应条件:交联剂用量0.08%(占丙烯酸单体的质量分数,下同),引发剂用量0.10%,丙烯酸的中和度60%,反应时间10 h.同时利用高吸水性树脂凝胶作为尿素控制释放基质,考察了高吸水树脂交联度、中和度等因素对尿素控制释放速率的影响.     

土-箱基-框架结构动力相互作用体系试验研究

通过对1/2大比例模型的试验与仿真分析,研究了结构-箱基础-土体系的动力反应.将实测基频结果与基于刚性地基的仿真分析结果对比,发现实测结果小于有限元结果;但将实测基频结果与考虑相互作用的仿真分析结果对比,发现实测结果与仿真分析结果吻合,这说明土-箱基础-结构相互作用改变了结构体系的动力特性,使结构体系的自振周期延长,同时也验证了仿真分析的有效性.     

钢纤维混凝土桥面铺装层的细观应力破坏分析

基于复合材料力学和线弹性断裂力学,简化了桥面铺装层及桥面板体系的力学模型,建立了修正的剪滞控制方程组.将模型裂缝区及远场的应力、位移条件合理转换为所建立计算模式的求解边界条件,进而得到了桥面铺装层和桥面板各子层的位移分布函数.运用能量法则,考虑温度效应对桥面铺装层的影响,得到了桥面铺装层破坏应力的解析解.运用该计算模式对某桥桥面铺装层的破坏进行了仿真分析,证实了该方法的适用性.     

柴油机燃用生物柴油燃烧与排放

研究了柴油机燃用0号柴油和生物柴油的燃烧放热规律．通过对燃烧特征参数的计算分析,发现生物柴油的燃烧始点有所提前,滞燃期缩短;燃烧初期放热尖峰出现时刻对应的曲轴转角有所提前,瞬时放热率峰值下降;燃烧持续期延长．同时还比较了柴油机燃用生物柴油和0号柴油的经济性和排放特性,发现燃油消耗率增加12％,而各种排放污染物除NOx略有上升外,CO、HC和颗粒物PM均显著下降．     

浅谈新闻写作角度和方法

文章结合自身从事新闻写作多年的经验,重点从新闻稿素材积累和选取的方法、选题的角度等分析和论述写作技巧。     

Comparison study of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin microspheres

To compare two microspheres of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin loaded theophylline as pulmonary sustained drug delivery carriers, the characteristics and ciliotoxicity were studied. The drug loadings of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin microspheres were 21.09% and 21.42%, and the encapsulation efficiencies were 91.40% and 92.80%. The distributions of 50% (d _0.5) of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin microspheres were 4.89 and 5.83 μm, respectively. Both microspheres showed spherical shape with smooth or wrinkled surfaces. FT-IR of chitosan/β-cyclodextrin microspheres demonstrated that theophylline had formed hydrogen bonds with chitosan and β-cyclodextrin, while for the carboxymethyl chitosan/β-cyclodextrin microspheres theophylline had interaction with carboxymethyl chitosan. The moisture absorption showed that an equilibrium was reached within 24 h. The two microspheres possessed better adaptability. In vitro release of theophylline from chitosan/β-cyclodextrin microspheres was slower than that from carboxymethyl chitosan/β-cyclodextrin microspheres at pH 6.8. Biography: LI Ruobao(1968–), male, Associate professor, research direction: foundation research of respiratory system.