RLC暂态过程τ值的统一性解释

对ＲＬＣ暂态过程中欠阻尼、临界阻尼和过阻尼的τ值给出了统一的物理解释．     

4-Hydroxynonenal-modified amyloid-beta peptide inhibits the proteasome: possible importance in Alzheimer's disease

The amyloid β-peptide (Aβ) is a 4-kDa species derived from the amyloid precursor protein, which accumulates in the brains of patients with Alzheimer’s disease. Although we lack full understanding of the etiology and pathogenesis of selective neuron death, considerable data do imply roles for both the toxic Aβ and increased oxidative stress. Another significant observation is the accumulation of abnormal, ubiquitin-conjugated proteins in affected neurons, suggesting dysfunction of the proteasome proteolytic system in these cells. Recent reports have indicated that Aβ can bind and inhibit the proteasome, the major cytoslic protease for degrading damaged and ubiquitin-conjugated proteins. Earlier results from our laboratory showed that moderately oxidized proteins are preferentially recognized and degraded by the proteasome; however, severely oxidized proteins cannot be easily degraded and, instead, inhibit the proteasome. We hypothesized that oxidatively modified Aβ might have a stronger (or weaker) inhibitory effect on the proteasome than does native Aβ. We therefore also investigated the proteasome inhibitory action of Aβ _1–40 (a peptide comprising the first 40 residues of Aβ) modified by the intracellular oxidant hydrogen peroxide, and by the lipid peroxidation product 4-hydroxynonenal (HNE). H₂O₂ modification of Aβ _1–40 generates a progressively poorer inhibitor of the purified human 20S proteasome. In contrast, HNE modification of Aβ _1–40 generates a progressively more selective and efficient inhibitor of the degradation of fluorogenic peptides and oxidized protein substrates by human 20S proteasome. This interaction may contribute to certain pathological manifestations of Alzheimer’s disease Received 26 September 2000; accepted 26 September 2000     

二阶退化双曲型方程的第二类广义Darboux问题

A.V.Bitsadze在文[1]中提出和研究了二阶一致线性双曲型方程uxx-uyy+aux+by+cu+d=0(A)的第一类和第二类Darboux问题.本文的目的是讨论二阶退化双曲型方程第二类广义Darboux问题和斜微商问题解的表示式,并证明这些问题解的存在唯一性。本文使用不同于[1]中的方法,但类似于[1]中的方程(A),根据本文中的结果,我们可以解决广义Chaplygin方程在一般区域上的Frankl问题.     

胰岛素信号通路PI3K／Akt对海马神经元β-淀粉样前体蛋白裂解酶1mRNA水平的影晌

目的通过胰岛素和磷脂酰肌醇-3激酶（P13K）抑制剂渥曼青霉素（wortmannin）对P13K／丝氨酸苏氨酸蛋白激酶（P13K／Akt）信号通路的激活和抑制作用,观察P13K／Akt信号通路对海马神经元β-淀粉样前体蛋白裂解酶1（BACEl）mRNA水平表达的影响。方法20只sD大鼠随机分为空白对照组、假手术组、胰岛素组和渥曼青霉素组,海马立体定向注射胰岛素和P13K抑制剂渥曼青霉素。逆转录一聚合酶链反应（RT-PCR）检测P13K／Akt信号传导下游蛋白Akt以及BACEImRNA水平。结果注射胰岛素的海马P13K信号通路下游信号分子：AktmRNA表达上调（分别较空白和阴性对照组P=0．047,P=0．002）,而BACElmRNA表达下调（分别较空白和阴性对照组P=0．004,P=0．01）。渥曼青霉素组的P13K下游信号分子AktmRNA表达明显被抑制（分别较空白和阴性对照组P=0．002,P=0．039）,同时BACEImRNA的表达较对照组上调（分别较空白和阴性对照组P=0．039,P=0．018）。结论胰岛素信号通路P13K／AM可以调节BACEl的转录水平参与阿尔茨海默病的发病机制。     

一个分数阶四维超混沌系统的同步研究

本文对一个分数阶四维超混沌系统应用一步耦合法进行同步设计构造,并利用拉普拉斯终值定理从理论上证明了其同步的有效性,应用预校-估正法将分数阶系统离散化,用数值模拟仿真验证了理论分析的正确性,实现初值不同的分数阶超混沌系统的耦合同步.     

儿童连身裤结构参数与人体运动适应性研究

采用人体体表描线法对8～9岁男童进行皮肤变化率的测量实验,通过测量人体动、静态6种动作下的皮肤变化率,得出影响儿童连身裤设计的结构参数,即背长、胸围、臀围、立裆及它们的取值范围.     

满-通古斯文化与迟子建小说研究

迟子建成长于我国满-通古斯语族的核心区域——大兴安岭,其小说在精神特质和艺术表达上都鲜明地体现出满-通古斯文化的印记。迟子建小说中的满-通古斯文化因素既是满-通古斯文化的一种存在形态又是一种独特的文化创造,它蕴含着东北边疆地区的文化心理、价值规范和精神内核。以满-通古斯文化为视阈研究迟子建小说,不但可以系统地挖掘迟子建小说中满-通古斯文化背后的价值取向和审美意蕴,还能阐释和把握其精神图像和风格特色。因此,满-通古斯文化与迟子建小说研究进一步探寻了东北地域文学研究的深层文化和精神维度,有着立足地域又超越地域的学术价值。     

一种混沌神经网络模型及其在优化中的应用

通过在Hopfield神经网络模型 (HNN)中引入非线性自反馈项 ,提出了一种具有暂态混沌动力学行为的神经网络模型。该模型首先经过一个倍周期倒分叉过程进行混沌搜索 ,进而进行类似HNN的梯度搜索。由于它利用了混沌搜索固有的随机性和轨道遍历性 ,因而具有较强的克服陷入局部极小的能力。两个典型的函数优化例子表明了该算法的有效性     

利用计算机模拟PC电路实验

本文对RC电路实验进行了计算机模拟求解，这时现有的PC电路实验是一个很好的补充，同时它也表明计算机解决物理问题是一个很好的途径。     

Hurst’s analysis to detect fluctuation of the jet in a two-dimensional fluidized bed

The experimental study of vertical jet in a two-dimensional fluidized bed is presented. The time series of vertical jet penetration depth are acquired by image processing. The fluctuation of jet which is studied by means of Hurst’s analysis becomes weaker with increase in jet velocity, fluidization number, particle diameter and static bed height. They are found that the signal is persistent and the fractal dimensional of vertical jet is between 1. 19 and 1. 64. Foundation item: Supported by Doctoral Foundation of China Biography: Zhou Ya-ming (1971-), male, born in 1971, Ph. D Candidate, majored in basic theory of two-phase fluid and fluidized bed.