关于图的第二特征标R2(G)

对任意图G，h(G，x)表示图G的伴随多项式，R2(G)表示图G的第二特征标，本文刻画了R2(G)=-2，-1，0，1，2的全部连通图。     

O－芳基－苯基硫代膦酰氯和O－芳基－苯基硫代膦酸异硫氰基酯的研究

合成一些新的有机磷化物，组成为（ＡｒＯ）ＰｈＰ（ｓ）Ｙ（Ｙ＝Ｃｌ、ＮＣＳ）．测定了ｍＰ、ＩＲ、ＨＮＭＲ并进行了元素分析．Ｉａ的除草活性尚好．     

C60偶联多孔硅系统的蓝光发射

用G60作为表面钝化剂，与多孔硅进行偶联．发现当C60偶联多孔硅系统在空气中存储一年后，能够发射460nm左右的强烈蓝光．经过系统的测量和分析，认为蓝光起源的发光中心与SiO2体材料中的“自捕获激子”模型类似．它是由一个氧空位和一个间隙氧组成的，间隙氧同时和相邻的晶格氧形成过氧连接．光激发载流子来自于Si纳米晶粒的核心，辐射复合过程则在多孔硅表面的发光中心进行．进一步的电子束辐照和臭氧辐照实验证明了这个发光中心的存在．从FTIR谱的分析，推测是样品表面Si=O双键的缓慢变化促使了蓝光中心的自发产生．     

Science Letters： A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors （TLRs） plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 （TLR2） ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen （HDM）. Mice were sensitized and challenged with Dermatophagoidesfarinae allergen （Der f）, and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid （BALF）. Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

激光光束质量的评价方法

激光光束质量是一个很有现实意义的论题，对不同应用的激光光束其质量的评价标准一般不同。给出了几种有代表性的激光光束质量的评价方法，并分别对各种评价标准的合理性与适用性进行了详细的分析；研究了实际应用中对激光光束质量的一些要求和相关的评价参数。     

Specific anti-tumor effect induced by attenuated Salmonella typhimurium vaccine expressing extracellular region of vascular endothelial growth factor receptor 2

The purposes of this research were to study the stable expression of exogenous gene encoding therapeutic protein in attenuated Salmonella typhimurium, observe the metabolism of oral gene vaccine carried by attenuated Salmonella typhimurium in BALB/c mouse, and investigate the feasibility of prevention and treatment of tumors by the recombinant bacteria. Recombinant plasmid pcDNA3.1 VEGFR2(n1-7) was transformed into competent attenuated Salmonella typhimurium SL3261 to develop oral DNA vaccine SL3261-pcDNA3.1 VEGFR2(n1-7). To observe whether the exogenous gene can be expressed in the recombinant bacteria, PCR was performed to amplify the CMV promoter of the eukaryotic expression vector as the proof of stable expression of exogenous protein; transmission elec- tron microscopy (TEM) was applied to observe the morphology of the recombinant bacteria to confirm that the exogenous gene has no impact on the growth of the bacteria, and then BALB/c mice were immunized with the gene vaccine. After inoculation of the gene vaccine, the recombinant bacteria SL3261 could be detected in the tissues such as small intestine, colon, liver and spleen. And then, mice in each group were challenged with tumor cells. The results of animal experiment showed that tumor growth of the mice in experimental group was inhibited and survival time of immunized mice was prolonged compared with control groups. A higher lymphocyte infiltration in tumors from animals treated with DNA vaccine was observed. Immunohistochemical analysis of tumor samples revealed an en- hanced accumulation of CD8 cytotoxic T lymphocytes, as well as an increase in CD4 cells in the tumors of animals treated with the oral gene vaccine compared to tumors from control group mice. Ultrastructure of the tumor tissue showed that tumor cells in the samples of the immunized mice were well-differentiated. Our research confirmed that the exogenous gene can be stably expressed in the attenuated Salmonella typhimurium and has no impact on the growth of the recombinant bacteria; the exogenous gene can de delivered to the host by attenuated Salmonella typhimurium to produce anti-tumor effect with no obvious cytotoxity to the host. In this study, it is established that attenuated Salmonella typhimurium could be used as a vector for oral gene vaccine, and our study provided a theoretical basis for the body distribution and the metabolism of the recombinant bacteria. This strategy may provide a simple, safe and effective way for the prevention and treatment of tumors.     

我国存货准则与IAS2的比较与思考

我国已经颁布了新的存货准则,并于今年年初开始实施,这对于进一步规范企业存货的确认、计量和披露,提高会计信息的相关性和可靠性,完善我国会计准则体系,推动我国证券市场乃至整个社会主义市场经济的发展,将起到积极的作用.     

Eph受体家族和Ephrin-A5在NSCLCs中上调表达及其临床意义

采用荧光实时定量PCR的方法在48个非小细胞肺癌组织以及配对的正常肺组织中检测Eph/ephrin 基因的mRNA水平.发现肺癌组织中EphB4, EphB3 和 ephrin-A5的表达水平与配对的正常肺组织相比分别上调了60%,81%和65%,并具有显著的统计学差异. 而且,统计学分析发现ephrin-A5的表达水平与肿瘤分型、转移、性别、吸烟以及诊断年龄等临床病理学参数之间存在显著的相关性.此外,EphA2的表达水平与肿瘤大小、家族遗传史以及诊断年龄之间也存在显著的相关性.总之,这些结果提示EphB4, EphA2, EphB3 和ephrin-A5 在肺癌的发生和发展过程中可能以一种单独或者协同的形式发挥作用.这些蛋白有可能成为研究和诊断肺癌的重要靶向基因.     

Developmental modes of the Neoproterozoic-Lower Paleozoic marine hydrocarbon source rocks in China

Based on the researches on rock type, the mode of occurrence, diagnostic minerals and creatures, the sedimentary geochemistry and organic facies of Chinese marine source rocks from wells and outcrops, and on the research findings of developmental modes of foreign marine source rock, the authors consider that it is impossible to objectively make clear the formation mechanism of hydrocarbon source rock with high organic matter abundance by either single mode of preservation or high organic matter productivity. According to the Chinese geological features, the formation mechanism of the Neoproterozoic-Lower Paleozoic marine source rock is generalized into four modes, namely, thermal water activity-upwelling flow-anoxic; carbonate gentle slope-upwelling flow; xerothermic climate-brine euxinic milieu; and humid climate-retained euxinic milieu; as the Lower Cambrian undercompensation basin organic facies （the Tarim Basin, South China and southwestern margin of North China）, carbonate gentle lime mud bound organic facies （the Upper Ordovician in Tazhong region of the Tarim Basin and the Lower Silurian in the Upper Yangtze Platform）, the Middle Cambrian evaporation laggon organic facies （the Tarim Basin and the Upper Yangtze Platform）, enclosed undercompensation terrigenous bay organic facies （the Middle-Upper Ordovician in the west of the Tarim Basin, the Lower Silurian Long- maxi Formation in the Upper Yangtze platform）. Chinese marine sedimentations with lower organic matter abundance are generalized into two modes of consumption-dilution mode of open epicontinental sea and depletion-dilution mode of supercompensation basin.     

Effects of self evaluation on late ERP components

High-density event-related potentials (ERPs) were measured when participants were required to evaluate oneself, significant others (father and mother) and the most familiar public figures (Lei Feng and Jiang Qing) based on trait adjectives. There were three referential conditions and a non-referential control condition including self-evaluation (SE), significant other-evaluation (SOE), general other-evaluation (GOE), and semantic positivity-evaluation (SPE). The behavioral data showed that RTs to GOE condition were longer than the other three conditions. Scalp ERP analysis revealed that (1) SPE condition elicited a more negative N2 than SE condition, which was associated with inhibition of responses; (2) SE condition elicited a more positive P300 than SPE condition, which was an index of attention to self-relevant stimuli; (3) there was no difference on the amplitude and latency of P300 between SE and SOE conditions, which reflected that the concept of “self” included intimate others (e.g., father and mother) in Chinese culture.