Molecular evidence for increased hematopoietic proliferation in the spleen of the b/b laboratory rat

The splenomegaly and the appearance of a significant number of CFU-E (erythroid colony-forming units) and BFU-E¹ (erythroid burst-forming units) in the Belgrade laboratory rat (b/b) spleen prompted us to analyse further the molecular evidence for increased hematopoietic proliferation in the b/b spleen. Messenger RNAs (mRNAs) specific for globins, proteins for iron transport and deposition and the band 3 protein were used in rat erythropoietic tissues as markers for proliferation and erythroid differentiation. In the b/b spleen, all mRNAs analysed display an erythroid-specific pattern of expression. This analysis also revealed an enhanced level of mRNA for ferritin in the +/b spleen, whereas erythrocyte-specific mRNA production was normal.     

Antiviral activities of anthraquinones,bianthrones and hypericin derivatives from lichens

The antiviral activities of some naturally occurring anthraquinones bianthrones, and hypericin derivatives were compared by the end-point CPE (viral cytopathic effects) method and plaque assays. Under optimal conditions of exposure to light, hypericin, 7,7-dichlorohypericin and 5,7-dichloroemodin exhibited strong inhibitory activity against HSV-1 (herpes simplex virus type 1) in both assays. Partial inactivation of the virus was shown by emodin, 7-chloroemodin and 7-chloro-1-O-methylemodin; the bianthrones and other anthraquinones were found to be inactive. Antiviral activity appeared to be, positively correlated with increasing substitution of chlorine in the anthraquinone structure. In the absence of light, only hypericin and 7,7-dichlorohypericin displayed detectable activity.     

笔段型液晶显示器图形基元的计算机辅助设计系统

利用AutoLIST语言编程,对AutoCADR12系统进行二次开发,开发出绘制笔段型液晶显示器图形基元的计算机辅助设计系统"BJ"．使人机交工绘制基元图形的过程,转化为通过给定设计参数,自动生成基元图形的过程。节省了作图时间,降低了繁琐作图过程对菲林设计的干扰。     

土壤中碳酸钙和有机碳测定的一种新方法

利用阿曼苏丹国的一千多个土壤样品,对土壤中碳酸钙和有机碳测定的实验方法进行了研究。发现实际碳酸钙的含量可由“亚稳态”时碳酸钙含量乘以适当的因子代替,从而大大提高了工作效率。而利用有机碳/全氮(C/N)的特殊规律,则可建立一个确定“有机碳”实验中所需土壤样品量的新方法。     

Cyclophosphamide-impaired regulation of hepatic heme metabolism

Summary Im male rats hepatic cytochromes b₅ and P-450 were reduced at different times after treatment with cyclophosphamide (CP) (200 mg/kg i.p. for 3 days). In contrast, microsomal heme did not change until 48 h after the last dose of CP, leading to accumulation of heme in a non-cytochromal form. Parallel to the above changes the heme metabolism showed derangement: -aminolaevulinate synthase, the rate-limiting enzyme in heme synthesis, was depressed and heme oxygenase, the enzyme which catalyzes the oxidative degradation of heme, was increased.     

粉末高温合金平衡相析出行为的热力学对比

利用热力学平衡相计算方法及相应的高温合金数据库对René95,Rene88DT和эп741нп三种合金在平衡相析出温度范围和析出量以及之间的关联性进行了系统的热力学计算对比分析.结果表明:三种粉末高温合金的平衡相种类基本相同,主要平衡相为γ,γ'和碳化物M23C6,MC,M6C.René95合金中的碳化物含量要高于其他两种合金.3п741нп有着较高的γ'相析出温度和较大的析出量.随温度降低,Co和Nb从γ'相中析出,在其周围富集,其中3п741нп合金中尤为明显.合金元素的偏聚度也和合金的初熔点与终熔点之差的大小有关,其熔解区间越大即初熔点和终熔点之差越大,合金元素的偏聚度越大.     

奈必洛尔中间体的不对称合成

(S,R,R,R)-奈必洛尔是一种新型、强效的β1-肾上腺素能受体阻滞剂降压药物.采用氧化/Wittig烯化一锅煮反应和Sharpless不对称环氧化/环化一锅煮反应,经八步反应,不对称合成出(S,R,R,R)-奈必洛尔的两个关键中间体1-[6-氟-(2S)-3,4-二氢-2H-2-苯并吡喃]-(1R)-1,2-乙二醇和1-[6-氟-(2R)-3,4-二氢-2H-2-苯并吡喃]-(1S)-1,2-乙二醇.该合成路线工艺简单,单步反应产率高,八步反应总收率达19%.     

基于W eb和开源技术的“生产管理系统”的开发与应用

主要介绍了当今流行的W eb技术、面向对象的Java编程语言及一系列的开放源代码技术,并就美国一家公司的“生产管理系统”从原有的C/S结构移植到基于W eb的B/S结构的改造工程,论述了整个系统的移植过程,及其成功经验,最后总结了我们在进行企业信息化建设过程中可借鉴之处.     

CAPP技术推广应用的探讨

介绍了CAPP技术的发展和现状，企业对CAPP技术的需求，选取CAPP软件应注意的问题，针对CAPP推广应用中存在的问题，提出了解决的方法。     

Pro／E在玻璃模具设计过程中的应用

以一种刻字的玻璃器皿模具制作为例，介绍了Pro／E软件在玻璃模具设计过程中三维造型和快速成型中的应用，为玻璃模具的快速制造提供了一个可靠的设计平台，并为玻璃模具制造奠定基础．