多组独立样本下一般统计函数的渐近性质

统计学家PaulJanseen等人于1984年引入了一般统计函数类，巧妙地运用Gateaux微分及U统计量的一些结果得到了一般统计函数类的渐近正态性质，本文在他们工作的基础上进行了推广，引入了多组样本条件下的一般统计函数类，并利用Generalized-U统计量的性质及Gateaux微分得到了多组独立样本下一般统计函数的渐近正态性质。     

支持向量机的研究与发展

支持向量机是一种新型机器学习方法。是在统计学习理论基础上发展起来的一种新的数据挖掘方法,并已广泛应用于模式识别与回归分析。已成为国际机器学习界的研究热点。笔者主要对其基本原理与研究发展情况进行了探讨和研究。     

基于多元共生遗传神经网络的藻类预测仿真

提出一种多元共生遗传神经网络(PGANN),从遗传算法和神经网络——进化和学习两方面及其相互关系着手完善进化过程,以提高优化效果和泛化能力。该算法包括一个共生平衡交叉算子,一种多元选择策略和一种神经网络的分级优化策略,其中共生平衡算子能够兼顾进化过程中的方向性、多样性和自适应性;多元选择策略能够适应进化过程不同时段对选择压力不同的需求;而分级优化使运算规模和运算速度之间的矛盾得到缓解。将该改进的遗传神经网络PGANN应用于水库和湖泊有毒的优势蓝绿藻爆发预测,取得了满意的效果。     

The cold case: Are rhinoviruses perfectly adapted pathogens?

Rhinoviruses, which cause common cold, belong to the Picornaviridae family, small non-enveloped viruses (diameter 15-30 nm) containing a single-stranded RNA genome (about 7 kb). Over 100 different rhinoviral serotypes have been identified thus far, establishing rhinoviruses as the most diverse group of Picornaviridae. Based on receptor binding properties, rhinoviruses are divided into two classes: the major group binding to intracellular adhesion molecule-1 and the minor group binding to the very low density lipoprotein receptors. Interactions between virus and the receptor molecules cause a conformational change in the capsid, which is a prerequisite for viral uptake. Rhinoviruses trigger a chemokine response upon infection that may lead to exacerbation of the symptoms of common cold, i.e. asthma and inflammation. The following review aims to summarize the knowledge about rhinoviral infections and discusses therapeutical approaches against this almost perfectly adapted pathogen.     

Telomeres and meiosis in health and disease

Telomeres are important segments of chromosomes that protect chromosome ends from nucleolytic degradation and fusion. At meiosis telomeres display an unprecedented behavior which involves their attachment and motility along the nuclear envelope. The movements become restricted to a limited nuclear sector during the so-called bouquet stage, which is widely conserved among species. Recent observations suggest that telomere clustering involves actin and/or microtubules, and is altered in the presence of impaired recombinogenic and chromosome related functions. This review aims to provide an overview of what is currently known about meiotic telomere attachment, dynamics and regulation in synaptic meiosis.     

From endoderm to pancreas: a multistep journey

The formation of the vertebrate pancreas is a complex process that typifies the basic steps of embryonic development. It involves the establishment of competence, specification, signaling from neighboring tissues, morphogenesis, and the elaboration of tissue-specific genetic networks. A full analysis of this multistep process will help us to understand classic principles of embryonic development. Furthermore, this will provide the blueprint for experimental programming of pancreas formation from embryonic stem cells in the context of diabetes cell-therapy. Although in the past decade many studies have contributed to a solid foundation for understanding pancreatogenesis, important gaps persist in our knowledge of early pancreas formation. This review will summarize the current understanding of the early mechanisms coming into play to pattern the "pre-pancreatic" region within the endoderm and, gradually, specify the pancreatic tissue.     

The macromolecular peptide-loading complex in MHC class I-dependent antigen presentation

A challenging task for the adaptive immune system of vertebrates is to identify and eliminate intracellular antigens. Therefore a highly specialized antigen presentation machinery has evolved to display fragments of newly synthesized proteins to effector cells of the immune system at the cell surface. After proteasomal degradation of unwanted proteins or defective ribosome products, resulting peptides are translocated into the endoplasmic reticulum by the transporter associated with antigen processing and loaded onto major histocompatibility complex (MHC) class I molecules. Peptide-MHC I complexes are transported via the secretory pathway to the cell surface where they are then inspected by cytotoxic T lymphocytes, which can trigger an immune response. This review summarizes the current view of the intracellular machinery of antigen processing and of viral immune escape mechanisms to circumvent destruction by the host. Received 4 October 2005; received after revision 19 November 2005; accepted 24 November 2005