X波段柱面共形基片集成波导纵向缝隙天线阵的实验

利用基片集成波导SIW(substrate integrated waveguide)技术设计了一款X波段柱面共形的SIW纵向缝隙谐振天线阵.通过分析柱面共形的SIW的传输特性,沿用传统矩形波导谐振缝隙天线阵的设计方法,设计了柱面共形的SIW纵向缝隙谐振天线阵.该天线具有传统的矩形波导缝隙天线阵主瓣宽度窄、方向图可以赋形、交叉极化电平低等优异特性,同时实现了天线的小型化、轻型化.由于基片集成波导完全集成于介质基片中,使得天线与平面电路的馈电连接变得非常简单,可以用微带直接馈电,减少了中间馈电电缆以及馈电转接头的损耗,从而使天线和平面电路的集成也成为可能.实验结果验证了这种设计方法的正确性.     

重力式抗滑挡墙最优截面的模式搜索法

在满足安全要求的前提下,为了减少重力式抗滑挡墙的材料用量,降低工程造价,以抗滑挡墙的几何参数为优化变量,以截面面积为优化目标函数,在满足抗滑移、抗倾覆和地基承载力等约束条件的基础上,建立了重力式抗滑挡墙的优化模型,并用Hooke-Jeeves模式搜索算法求解,并编制了优化设计程序.通过对某抗滑挡墙的优化分析,结果表明:采用本文方法对重力式抗滑挡墙进行优化,在满足安全的条件下可以明显的降低工程费用,在滑坡治理工程中具有一定的实用价值.     

o/w微乳液中制备甲基丙烯甲酯-苯乙烯共聚物超细颗粒

在甲基丙烯酸甲酯（ＭＭＡ）－苯乙烯－环己烷／十六烷基三甲基溴化铵（ＣＴＡＢ）／水体系的ｏ／ｗ微乳液中,制备了粒径约５８ｎｍ球状甲基丙烯酸甲酯－苯乙烯共聚物超细颗粒,研究了影响粒子形态和大小的因素。     

硫酸庆大霉素聚乳酸微球的制备及其体外缓释度的测定

以硫酸庆大霉素为囊心物质,采用复乳法制备了硫酸庆大霉素-聚乳酸微球（gentamycin sulfate-polylactic acid-microspheres,GTMS-PLA-MS）,比较了不同制备条件下所得微球的差异.扫描电镜（SEM）测试表明微球外观呈球形并且多孔,两种条件下制备的微球平均粒径分别为6.67 μm和11.70μm,药物包封率分别为37.52%和49.19%.用差热分析法（DTA）分析微球得知,硫酸庆大霉素与聚乳酸两种物质相互融为一体.以pH=7.4的磷酸盐缓冲溶液为释药介质,用紫外分光光度法（UV）对载药微球的体外释药过程进行了试验.结果表明,微球在最初20 min有突释效应,此后是缓慢释药,最终累积释药量达95%以上.     

Antiproliferative effects of 4′, 5′-unsaturated adenine nucleosides on leukemia L 1210 cells in vitro

Summary Several 4, 5-unsaturated adenine nucleosides were shown to have antiproliferative activity against L 1210 leukemia cells in vitro. The active nucleosides were cytotoxic to the L 1210 cells as demonstrated by Trypan Blue uptake. The cytotoxicity was not induced by alterations in the ribonucleoside and deoxyribonucleoside triphosphate levels of the L 1210 cells.     

Novel rearrangement of purines

Summary 6-Trichloromethyl-9-methylpurine (1) rearranges to 6-dichloromethyl-9-methyl-8-oxopurine (2) in aqueous mild acidic solution. The rearrangement is rationalized in terms of a reaction involving protonation, covalent hydration, prototropic equilibrium and/or a hydride transfer. An alternative mechanism involving a positive halogen compound and hypochlorous acid as an intermediary is also proposed. Compound1 condenses with 4,5-diaminopyrimidine to give the purine-pyrimidine Schiff base pair4.Acknowledgments. We are deeply indebted to Professor S. Cohen of the Sackler School of Medicine, Tel Aviv University (Ramat Aviv, Isreal) for his advice and encouragement. Support of this research by the Israel Cancer Association, the Ber-Lamsdorf Foundation Switzerland Israel and by the Advancement of Mankind Foundation, is gratefully acknowledged. We thank Proff. D. Arigoni and A. Eschenmoser, ETH Zürich, for their valuable proposals and comments on the mechanism of the rearrangement.     

Alzheimer's disease: fundamental and therapeutic aspects

Alzheimer's disease is the most common type of progressive and debilitating dementia affecting aged people. In some early — as well as late-onset familial cases, a genetic linkage with chromosomes 14, 21 (early-onset) or 19 (late-onset) has been indicated. Furthermore, a direct or indirect role has been attributed to normal or structurally altered amyloid -protein (concentrated in senile plaques) and/or excessively phosphorylated tau protein (located in neurofibrillary tangles). Degeneration of cholinergic neurons and concomitant impairment of cortical and hippocampal neurotransmission lead to cognitive and memory deficits. Several compounds are being tested in attempts to prevent and/or cure Alzheimer's disease, including tacrine, which has very modest efficacy in a sub-group of patients, and new acetylcholinesterase inhibitors. Pilot experiments have also been launched using nerve growth factor (NGF) to prevent or stabilize the processes of cholinergic pathway degeneration. Alternatively, antioxidants, free radical scavengers and/or non steroidal anti-inflammatory agents may be screened as potential therapies for neurodegenerative diseases induced by multiple endogenous and/or exogenous factors. The recent use of transgenic mice, in parallel with other genetic, biochemical and neurobiological systems, in vivo and/or in vitro (cell cultures), should accelerate the discovery and development of specific drugs for the treatment of Alzheimer's disease.     

17β-Estradiol-sensitivity of cultured myometrial cells

Summary The estrogen sensitivity of cells cultured from the rat myometrium was studied by growing the cells in the absence or presence of 1 nM 17-estradiol. Following a time lag of 10 days, exposure to estrogen resulted in increased incorporation of radiothymidine by the cells. Estrogen treatment also decreased isoproterenol-dependent and GTP-dependent adenylate cyclase activity, but had no effect on basal activity. These cultured cells have been shown previously to have some properties of uterine smooth muscle. The effects estrogen has in viyro, therefore, may reflect important properties in vivo that account for the mechanism by which the sex steroid decreases the sensitivity of the myometrium to isoproterenol.     

介质覆盖曲面上非镜面波散射研究

提出一种表面爬行波新概念，并运用此概念，研究介质覆盖导电曲表面上非镜面波的散射特性、覆盖介质的电磁参数和涂层厚度变化时覆盖介质对表面爬行波散射抑制作用的变化趋势。     

原油乳状液液滴建模与小变形动力学分析

从微观角度出发,根据运动学基本定律,建立乳状液液滴受力模型,同时进行了乳状液液滴的小变形动力学分析,并进行了模型求解和仿真,为原油电脱水的自动控制提供了理论基础。