中草药防治鳖暴发性传染病

科果介绍鳖常见暴发性传染病的病原和预防措施，重点阐述了实践中筛选出来的防治鳖白点病，红脖子病，疖疮病，白底板病、出血病和腮腺炎等６种暴发性传染病的中草药配伍方剂，及其使用剂量和使用方法。     

广西大学女教工妇科病调查分析

对广西大学８９８名已婚女教工妇科病进行调查分析，结果发现女教工妇科病总发病率为４５．１％，其中几种常见病如子宫颈炎、阴道炎、子宫肌瘤发病率分别为２８．１％，４．７％，４．０％。其次为更年期，为４１．９％，老年期最低，为１１．９％，依据以上的发率规律，提出防治措施。     

Deficiency of kallikrein-like enzyme activities in cerebral tissue of patients with alzheimer's disease

Summary We examined the changes in the intracerebral activities, at the time of postmortem autopsy, in patients with Alzheimer's disease. When compared with the control group, the activity of kallikrein-like enzyme was significantly decreased, while prolyl endopeptidase activity increased, in the patients group. Aprotinin inhibited 50% of the activity of the former enzyme at 2×10^–7M. Taken together with the results of a multivariate study, the above findings may indicate that intracerebral kallikrein deficiency plays an important role in the pathogenesis of Alzheimer's disease.     

苹果轮纹病的发生与防治

介绍了苹果轮纹病的成因，发病机理及症状等，提出了一些综合防治措施，如选栽抗病品种和抗病砧木，加强栽培管理等。     

基于三重注意力机制的新冠肺炎病灶分割模型

为了解决感染区域比正常组织对比度低的问题,提出了一种基于三重注意力机制(triple attention mechanism,TAM)的新冠肺炎(corona virus disease 2019,COVID 19)病灶分割模型——TM-Net,并将其应用于条件生成对抗网络.MultiConv模块可以自动提取肺部切片中...     

链格孢属真菌对农作物的危害

链格孢属(Altemaria)真菌是农作物的主要致病菌之一,它能引起包括玉米、小麦、烟草、马铃薯、番茄、苹果、梨等几十种农作物发病,其发病机理主要是由病菌的代谢产物——毒素导致的,由于毒素的作用使农作物产生各种症状,如黑斑病、褐斑病、茎枯病、赤星病等等,严重影响了农作物的产量,给我国农业生产带来了巨大损失。     

On the mechanism of inhibition of p27 degradation by 15-deoxy-Δ12,14-prostaglandin J 2 in lymphoblasts of Alzheimer’s disease patients

It has been proposed that neuroinflammation, among other factors, may trigger an aberrant neuronal cell cycle re-entry leading to neuronal death. Cell cycle disturbances are also detectable in peripheral cells from Alzheimer’s disease (AD) patients. We previously reported that the anti-inflammatory 15- deoxy-Δ^12,14-prostaglandin J ₂ (15d-PGJ ₂) increased the cellular content of the cyclin-dependent kinase inhibitor p27, in lymphoblasts from AD patients. This work aimed at elucidating the mechanisms of 15d-PGJ ₂-induced p27 accumulation. Phosphorylation, half-life, and the nucleo-cytoplasmic traffic of p27 protein were altered by 15d-PGJ2 by mechanisms dependent on PI3K/Akt activity. 15d-PGJ ₂ prevents the calmodulin-dependent Akt overactivation in AD lymphoblasts by blocking its binding to the 85-kDa regulatory subunit of PI3K. These effects of 15d-PGJ ₂ were not mimicked by 9,10-dihydro-15-deoxy-Δ^12,14- prostaglandin J ₂, suggesting that 15d-PGJ ₂ acts independently of peroxisome proliferator-activated receptor γ activation and that the α,β-unsaturated carbonyl group in the cyclopentenone ring of 15d-PGJ ₂ is a requisite for the observed effects. Received 14 July 2008; received after revision 2 September 2008; accepted 12 September 2008     

Biological and Potential Therapeutic Roles of Sirtuin Deacetylases

Sirtuins comprise a unique class of nicotinamide adenine dinucleotide (NAD⁺)-dependent deacetylases that target multiple protein substrates to execute diverse biological functions. These enzymes are key regulators of clinically important cellular and organismal processes, including metabolism, cell division and aging. The desire to understand the important determinants of human health and lifespan has resulted in a firestorm of work on the seven mammalian sirtuins in less than a decade. The implication of sirtuins in medically important areas such as diabetes, cancer, cardiovascular dysfunction and neurodegenerative disease has further catapulted them to a prominent status as potential targets for nutritional and therapeutic development. Here, we present a review of published results on sirtuin biology and its relevance to human disease. Received 25 June 2008; received after revision 20 August 2008; accepted 29 August 2008     

MPTP慢性帕金森病小鼠海马内氧化应激与细胞凋亡蛋白的表达

目的 观察 MPTP慢性帕金森病小鼠海马氧化应激指标及细胞凋亡相关蛋白的表达.方法 应用MPTP制备慢性帕金森病模型,观察行为学改变,Morris水迷宫实验,检测模型组和对照组小鼠海马内超氧化物歧化酶（SOD）、还原型谷胱甘肽（GSH）及丙二醛（MDA）舍量变化,以及免疫组织化学方法、RT-PCR方法、Western blot方法检测海马Bax和Bel-2蛋白表达.结果 慢性帕金森病模型小鼠行为学特点为震颤、活动减少;水迷宫实验结果提示认知功能降低;与对照组海马比较：模型组海马SOD、GSH含量均下降,而MDA含量升高（P〈0.05）;模型组海马Bax蛋白表达增高,而Bel-2蛋白表达下降（P〈0.05）.结论 氧化应激在慢性帕全森病认知功能障碍发病机制中起重要作用,而Bax和Bcl-2蛋白参与了氧化应激诱导海马神经元凋亡的调控过程.     

中医病名英译规范策略

通过分析中西医疾病命名特点、中医英译原则,对中医病名英译的策略进行了较为深入的讨论。根据中西医病名含义的多种对应关系,采用首选意译、次选直译、控制音译和多种译法结合的翻译策略。详细论述了如何灵活应用三种翻译方法对各种中医病名进行翻译。