对湖南省大学生体育消费需要心理重塑的探讨

大学生对体育锻炼有着较高的认知水平，应该有着较高的体育消费水平。但是，我省大学生的体育消费水平并不高，除经济因素外，还与其不正确的体育消费心理有关，要适应现代社会发展的需求，需要重塑大学生正确的体育消费心理。     

Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour

Fibroblast proliferation is a key process in tissue remodeling and mast cells (MCs) are thought to play a crucial role. Having established that the three major MC products, tryptase, histamine and TNF-alpha (TNF) are normally present in human skin MCs, which are in close proximity to dermal fibroblasts, we studied their individual effects on cell cycle-controlled human dermal fibroblasts (HFFF2). These cells express receptors (H1, PAR2, TNFR1/2) for the major MC mediators, but only tryptase or a PAR2 agonist peptide stimulated proliferation and gene expression. TNF was antimitotic, and histamine, while elevating intracellular Ca²⁺ levels at high concentrations, did not affect proliferation. We conclude that MC products but also composition and numbers of respective receptors on fibroblasts are crucially responsible for fibroproliferative events. Received: 28 June 2005; received after revision 28 September 2005; accepted 6 October 2005     

论我国公共政策的价值偏离与重塑

公共政策要以实现公共利益为基本价值取向，我国公共政策在制定和执行过程中都出现价值偏离的现象，存在着公共政策“缺位”、“越位”现象，严重影响公共政策功能的发挥，甚至引发一系列社会问题。因此，需要采取行之有效的措施诸如树立正确的公平观、公共政策制定以及执行过程要体现公平的价值取向，来纠正这些偏差，重塑公共政策的价值。     

用正交异性算法仿真的肌力对股骨再造的影响

肌力与骨骼的生长(即"骨再造")有密切关系。该文基于CT数据建立股骨有限元模型,用正交异性算法仿真了肌力对骨再造的影响。骨再造仿真中,由复杂到简单共设置三组肌力载荷工况,使用正交异性算法结合有限元分析。结果表明,复杂肌力比简单肌力的仿真结果更符合股骨的真实密度分布和结构。肌力可以在一定程度上调节局部骨量大小和骨小梁的排列,对股骨近端影响较大,对中端和末端影响较小。对肌力做适当的简化不会影响骨密度分布和内部结构,但过于简化的肌力将显著影响局部骨量大小和骨小梁排列方向。     

西藏新型国有企业文化建设中的交互影响因素与融合

文章分析了传统国有企业文化、现代西方企业文化、西藏传统文化等方面对西藏新型国有企业文化建设的影响,指出转型和变革所带来的文化动荡能否在短时间内通过梳理、整合和重塑并形成新的企业文化,将决定西藏新国企在未来的发展中是否能够迅速形成新的核心竞争力,在市场竞争中取得优势,决定着西藏国有企业改革的成败。     

Emerging connections between DNA methylation and histone acetylation

Modifications of both DNA and chromatin can affect gene expression and lead to gene silencing. Evidence of links between DNA methylation and histone hypoacetylation is accumulating. Several proteins that specifically bind to methylated DNA are associated with complexes that include histone deacetylases (HDACs). In addition, DNA methyltransferases of mammals appear to interact with HDACs. Experiments with animal cells have shown that HDACs are responsible for part of the repressive effect of DNA methylation. Evidence was found in Neurospora that protein acetylation can in some cases affect DNA methylation. The available data suggest that the roles of DNA methylation and histone hypoacetylation, and their relationship with each other, can vary, even within an organism. Some open questions in this emerging field that should be answered in the near future are discussed.     

开胸术后病人的呼吸道护理

阐述了开胸术后病人呼吸道护理方法、护理结果、护理体会,为临床护理提供依据。     

显微损伤修复过程中骨组织纳米力学性能的变化

人工关节置换、骨折内固定等骨科植入物手术会在其周围造成显微损伤,这些机械性显微损伤会降低植入物周围骨的质量,影响其与植入物界面之间的结合强度,并进而影响植入物的长期稳定性.通过在山羊胫骨植入螺钉建立显微损伤模型,比较螺钉植入近端和远端两种不同情况下机械性显微损伤的产生和修复,以及修复过程中骨微观力学性能和骨组织元素成分的变化.结果发现:显微损伤产生和修复过程中,局部骨组织的硬度和弹性模量都呈现下降趋势;随着显微损伤修复的逐渐完成,其微观力学性能又有所恢复.     

p53-dependent upregulation of PIG3 transcription by γ-ray irradiation and its interaction with KAP1 in responding to DNA damage

PIG3 (p53-inducible gene 3), originally identified as one of a set of genes induced by p53 before the onset of apoptosis, was assumed to contribute to early cellular response to DNA damage. Here, we studied the relation between p53 status and the increased expression of PIG3 by ionizing radiation (IR), and the related clues regarding the involvement of PIG3 in the cellular response to IR-induced DNA damage signaling. We demonstrated that the pentanucleotide microsatellite sequence was responsible for the p5...     

近视巩膜生物力学研究进展

 近视是一种最为常见的具有致盲可能性的眼部疾患，其发病机制目前尚不完全明晰。巩膜可直接决定眼轴的长度，是近视形成的最终效应器。本文以巩膜为切入点，综述近视发生时巩膜组织生物力学性质的变化、相应巩膜组织成分的改变与原因，以及目前临床上针对性的近视治疗方案，展望了该研究领域的发展方向和趋势。