基于MC9S12XS128的自动电阻测试仪设计

本文以飞思卡尔公司的16位微处理器MC9S12XS128为控制芯片,用4×4矩阵键盘作为人与系统对话设备,用自带汉字库的带背光的12864LCD为显示器,设计了自动电阻测试仪。测试仪实现了100Ω、1KΩ、10KΩ、10MΩ四档位的精确测量,且在各档位间能实现自动切换;同时具有电阻筛选功能;测试仪还设计了自动测量电位器阻值随旋转角度变化的装置,能动态显示电位器阻值随旋转角度变化的曲线。系统性能稳定,测量精度高,具有相应的灵活性和实用性。     

辅酶Q_9的研究与探讨

文章介绍了一种半合成法制备辅酶Q的路线,即由芳香性主环Q与有广阔开发前景的天然提取物茄尼醇进行加90合,制取心血管新药辅酶Q9。此法成本低,可以大量合成,为进一步进行药理研究提供基础。并概述了辅酶Q9（包括辅酶Qn一类化合物）的功效及其应用情况,对其进一步的开发应用进行了展望。     

History of Science through Koyré's Lenses

Alexandre Koyré was one of the most prominent historians of science of the twentieth century. The standard interpretation of Koyré is that he falls squarely within the internalist camp of historians of science—that he focuses on the history of the ideas themselves, eschewing cultural and sociological interpretations regarding the influence of ideologies and institutions on the development of science. When we read what Koyré has to say about his historical studies (and most of what others have said about them), we find him embracing and championing this Platonic view of his work. Ultimately I think this interpretation of Koyré's history of science is lopsided and in need of correction. I claim, rather, that a careful reading of Koyré's work suggests that a tension exists between internal and external methodological considerations. The external considerations stem from Koyré's commitment to the unity of human thought and the influence he admits that the ‘transscientifiques’ (philosophy, metaphysics, religion) have on the development of science. I suggest in conclusion then, that if we are to put a philosophical label on his work, rather than ‘Platonist’, as has been the custom, ‘Hegelian’ makes a better fit.     

基于ARM9的航电综合控制单元主控模块的设计

本文结合航空电子综合控制单元的普遍需求,采用ARM9芯片AT91RM9200设计了其中的主控制和处理模块,通过对该模块电路结构和部分功能电路的介绍,描述了基于ARM9处理器设计控制模块的设计方法;实践表明,该设计具有很强的通信处理能力和接口能力,通用性较好。     

9,9-双-(丙酸丁酯基)芴及其聚合物的合成研究

以工业芴为原料,用丙烯酸丁酯为烷基化试剂,在温和的条件下,通过一步反应合成了9,9-双-(丙酸丁酯基)芴;研究了反应物摩尔数、反应时间和温度对合成反应的影响.结果表明最佳反应条件是:芴与丙烯酸丁酯的摩尔比为1∶8,反应时间为20m in,温度为35℃;以FeC l3为聚合催化剂,合成了可溶性的聚芴衍生物聚9,9-双-(丙酸丁酯基)芴;用DSC、IR、1HNMR、MS对其结构进行了表征.     

Cationic polymeric nanoformulation: Recent advances in material design for CRISPR/Cas9 gene therapy

CRISPR/Cas9 (clustered regularly interspaced short palindromic repeat/clustered regularly interspaced short palindromic repeat associated proteins 9) gene editing platform is a promising therapeutic tool for genetic disorders, due to its ability to manipulate the pathogenic gene in genomic level and to easily target specific gene by manipulating single-guide RNA. However, its successful delivery remains a challenge. Up to now, great efforts have been made to explore an effective strategy for CRISPR/Cas9 delivery. But among those delivery methods, physical methods are mainly operated on cultured cells thus limited to laboratorial use; viral vectors are hindered by fetal immunogenic and carcinogenic effects thus dubious in clinical application. Therefore, cationic polymeric vectors, with the ability to interact with CRISPR/Cas9 system to form a nanoformulation as a non-viral approach, are attracting increasing attentions, due to advantages such as well protection of cargos, less limitation in payload size, low immunogenicity or carcinogenicity, potential modifications for further functions, and ease in mass production. In this review, the recent discoveries on polymeric vectors utilized in delivery of CRISPR/Cas9 system will be summarized. With emphasis on advanced features of those polymeric vectors or their nanoformulations to meet the demands of different CRISPR/Cas9 delivery forms (plasmid, mRNA or protein), the detailed illustrations on their disease treatment applications, such as cancer, diabetes or antibiotic-resistant infections, will also be reviewed.     

加速度传感器在模型火箭定高分离中的应用

模型火箭定高分离是航天模型比赛的重要比赛项目之一,其难点在于高度的精确控制。为了使模型火箭能在设定高度分离,系统采用飞思卡尔MC9S08AW60单片机和集成3轴加速度传感器MMA7455模块,通过SPI数据传输协议将加速度传感器测得值传至单片机进行变加速度的二次积分运算求得高度值。实验测试结果表明,能完成对模型火箭高度的测定与其在定高分离的功能,其定高精度指标符合模型火箭定高分离系统的应用要求。     

脂肪醇聚氧乙烯醚合成反应的动力学研究——产物分布的统计矩

碱催化条件下，以离子反应机理进行的脂肪醇聚氧乙醇醚合成反应中，链转移反应是影响产物分布的重要因素。根据反应动力学方程的递推关系，本文采用Ｌａｐｌａｃｅ变换的方法，研究了产物分布的统计特征，得到了描述反应随时间推进分布均值及方差的变化规律表达式。结果表明，链转移反应是关联原料醇加入量及催化剂特征的重要环节。     

利用Multisim9进行电子电路仿真的教学研究

根据电子电路实验在学习本课程中的重要性，提出了在教学中利用Muhisim9进行仿真、分析与设计的思路．此软件的优点是灵活方便、实验速度快、效率高，克服了传统实验与实验室开放的局限．通过一个实例进行了阐述，从而促进理论教学，改善实验教学效果．     

蒽环类叔胺的合成与表征

以9-蒽甲醛为原料，和苄胺、芳香胺在冰乙酸的催化下脱水生成席夫碱，经过硼氢化钠还原，和3，5-二烷氧基苄基氯发生亲核取代反应，合成了一系列蒽环类叔胺化合物，并通过NMR、质谱对其结构进行了表征．