A major metabolite of Δ1-tetrahydrocannabinol reduces its cataleptic effect in mice

Summary The results described here demonstrate that THC-induced catalepsy in mice can be substantially inhibited by the prior administration of ¹-THC-7-oic acid, the major metabolite of THC in most species including humans. This raises the possibility that the intensity and duration of action of THC may depend to a large degree on the levels of this metabolite at the sites of action.We thank the National Institute on Drug Abuse for supporting this project by grants DA-02043 and DA-02052 and for supplying all of the cannabinoids. One of us (S.B.) is also the recipient of a Research Scientist Award from NIDA. We are grateful to Kristen Carlson and Thomas Honeyman for helpful suggestions in preparing this report.     

台湾地区SCI论文数在世界中所处的位置及统计分析

台湾的科技发展得到了世界越来越多的关注,本文通过SCI收录台湾地区的科技论文,从发表机构、学科、参考文献以及台湾地区科技论文的被引用等情况,介绍台湾地区的科技论文产出情况,以便了解台湾地区在世界科技中的地位和影响。     

The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins

The biological functions of the more than one hundred genes coding for deubiquitinating enzymes in the human genome remain mostly unknown. The USP25 gene, located at 21q11.2, encodes three protein isoforms produced by alternative splicing. While two of the isoforms are expressed nearly ubiquituously, the expression of the longer USP25 isoform (USP25m) is restricted to muscular tissues and is upregulated during myogenesis. USP25m interacts with three sarcomeric proteins: actin alpha-1 (ACTA1), filamin C (FLNC), and myosin binding protein C1 (MyBPC1), which are critically involved in muscle differentiation and maintenance, and have been implicated in the pathogenesis of severe myopathies. Biochemical analyses demonstrated that MyBPC1 is a short-lived proteasomal substrate, and its degradation is prevented by over-expression of USP25m but not by other USP25 isoforms. In contrast, ACTA1 and FLNC appear to be stable proteins, indicating that their interaction with USP25m is not related to their turnover rate. Received 7 November 2005; received after revision 7 January 2006; accepted 13 January 2006     

Immune responses to DNA vaccines

DNA vaccines, based on plasmid vectors expressing an antigen under the control of a strong promoter, have been shown to induce protective immune responses to a number of pathogens, including viruses, bacteria and parasites. They have also displayed efficacy in treatment or prevention of cancer, allergic diseases and autoimmunity. Immunologically, DNA vaccines induce a full spectrum of immune responses that include cytolytic T cells, T helper cells and antibodies. The immune response to DNA vaccines can be enhanced by genetic engineering of the antigen to facilitate its presentation to B and T cells. Furthermore, the immune response can be modulated by genetic adjuvants in the form of vectors expressing biologically active determinants or by more traditional adjuvants that facilitate uptake of DNA into cells. The ease of genetic manipulation of DNA vaccines invites their use not only as vaccines but also as research tools for immunologists and microbiologists. Received 26 October 1998; received after revision 3 December 1998; accepted 3 December 1998     

微山县耕地变化驱动力研究

根据济宁市微山县1990~2004年的相关统计数据,利用灰色关联分析方法确定了影响耕地面积变化的驱动因子,并对其最大驱动力进行了分析。结果表明:微山县耕地面积变化与农业总产值在工农总产值中的比例关联系数最大,达到0.815 85,其次为粮食单产、农作物播种面积、全社会固定资产投资完成额、GDP、城市化水平、公路客运量和社会消费品零售总额。最后通过其15a间的耕地面积变化数据,建立了耕地面积灰色GM(1,1)预测模型,平均相对误差为2.89%,精度较高,可以用于后期的耕地面积变化预测。     

Geometric error control in the parabola-blending linear interpolator

This paper considers geometric error control in the parabola-blending linear interpolation method （Zhang, et al., 2011）. Classical model of chord error by approximation with contact circle on the parabolas leads to incorrect result. By computing the geometric error directly without accumulating the approximation error and chord error, the authors realize correct geometric error control by establishing inequality constraints on the accelerations of the motion.     

改进群组G1组合赋权的省级科学发展评价模型及应用

根据科学发展观内涵,以权威机构典型观点的高频指标为基础, 从经济、生态、社会、人的全面发展、科学技术等五个方面构建了省级行政区科学发展综合评价指标体系. 运用标准差修正群组G1组合赋权的方法对评价指标进行赋权, 建立了改进的群组G1组合赋权的科学发展评价模型, 并对中国14个省级行政区的科学发展状况进行实证研究. 本文的主要创新与特色一是对专家给出的不同排序进行一致性检验, 淘汰不通过一致性检验的专家排序,避免指标排序出现逻辑混乱问题. 二是通过循环修正的思路统一通过一致性检验的不同专家对两个指标重要程度的排序, 得到集合不同专家意见的一个统一排序,解决了群组决策中专家排序不一致的问题, 三是通过相邻两个指标的标准差的比值确定G1赋权法的指标之间的重要性比率, 避免了现有研究中G1赋权法重要性之比人为主观确定、随意性大的问题,解决了主客观权重的客观分配问题.     

一种用于复杂战争过程的建模方法(Ⅰ)

本文重点介绍建模理论。现代战争系统是一个复杂系统,拥有复杂系统的所有特性,即物质、能量与信息的全面开放性,作用机制非线性和不确定性。以往的战争模型着重描述的是战场硬损耗过程,而对信息和C~3I系统等软因素缺乏描述。针对现代战争的特点我们提出了一种用于现代战争的建模方法,该方法基于复杂系统理论,能够全面描述现代战争过程的各要素,从而能够分析C~3I系统等在现代战争中的作用。     

特大规模组合电路测试数据产生方法研究

针对特大规模组合电路和全扫描设计电路提出了一种高速测试生成方法。该方法采用有限回溯测试模式产生方法生成测试码,采用ｎ（机器字长）个测试码并行的单故障传播方法模拟验证测试覆盖。测试生成与故障模拟为ｎ对１紧耦合集成方式。该方法运行１０个Ｂｅｎｃｈｍａｒｋ电路,取得了低测试长度、高故障覆盖、高效率的良好效果。