Novel rearrangement of purines

Summary 6-Trichloromethyl-9-methylpurine (1) rearranges to 6-dichloromethyl-9-methyl-8-oxopurine (2) in aqueous mild acidic solution. The rearrangement is rationalized in terms of a reaction involving protonation, covalent hydration, prototropic equilibrium and/or a hydride transfer. An alternative mechanism involving a positive halogen compound and hypochlorous acid as an intermediary is also proposed. Compound1 condenses with 4,5-diaminopyrimidine to give the purine-pyrimidine Schiff base pair4.Acknowledgments. We are deeply indebted to Professor S. Cohen of the Sackler School of Medicine, Tel Aviv University (Ramat Aviv, Isreal) for his advice and encouragement. Support of this research by the Israel Cancer Association, the Ber-Lamsdorf Foundation Switzerland Israel and by the Advancement of Mankind Foundation, is gratefully acknowledged. We thank Proff. D. Arigoni and A. Eschenmoser, ETH Zürich, for their valuable proposals and comments on the mechanism of the rearrangement.     

基于热红外遥感数据辽东地热区地表温度反演

为解决地热资源的勘探开发问题, 基于新型的 Landsat鄄8 热红外遥感数据, 采用大气校正法(RTE: Radiative Transfer Equation)反演出辽东地热区在 2014 年不同月份的地表温度, 并将反演结果中的高温异常区 与研究区内已知温泉点的空间分布特征进行对比, 结果表明, 两组数据在 8、 9 月份时具有很高的空间相关性。 该方法及结果对于探明辽东地热资源的空间分布及进一步勘探开发具有重要的指示意义。     

一种功能性轴向配位基的合成

二氧四胺大环(macrocyclic dioxotetraanine)配体因其独特的结构特点和性质而受到广泛的重视和关注.本文合成了一种溴代杂环8—溴代甲基喹淋,并作为功能性轴向给体侧臂成功地引入到十三员、十四员二氧四胺大环骨架上,发现喹啉侧臂的引入,改变了大环配体的配位环境并产生新的性质和功能     

8—羟基喹啉的亚硝基和硝基衍生物的合成

报道了以8-羟基喹啉为原料,合成5-和7-位的亚硝基和硝基衍生物。并做了差热分析和进行了讨论。     

N—（8—喹啉基）—N‘—苯甲酰基硫脲的极谱行为研究

本文研究了N-(8-喹啉基)-N’-苯甲酰基硫脲的极谱性质。发现在0.1mol·L~(-1)KBr-0.05mol·L~(-1)NaOH/K_2HPO_4溶液中,其产生三个清晰的阴极化示波极谱波,二次导数峰电位分别为-0.40V,-0.77V及-1.20V(VS.SCE),相应的线性范围依次是1.0×10~(-6)～4.0×10~(-5)mol·L~(-1),1.0×10~(-6)～5.0×10~(-5)mol·L~(-1),1.0×10~(-8)～2.0×10~(-6)mol·L~(-1)。文中对极谱波性质和电极反应机理进行了探讨。研究表明,前两峰分别为>C=S,>C=O的电还原,后者为氢催化波。     

Alzheimer's disease: fundamental and therapeutic aspects

Alzheimer's disease is the most common type of progressive and debilitating dementia affecting aged people. In some early — as well as late-onset familial cases, a genetic linkage with chromosomes 14, 21 (early-onset) or 19 (late-onset) has been indicated. Furthermore, a direct or indirect role has been attributed to normal or structurally altered amyloid -protein (concentrated in senile plaques) and/or excessively phosphorylated tau protein (located in neurofibrillary tangles). Degeneration of cholinergic neurons and concomitant impairment of cortical and hippocampal neurotransmission lead to cognitive and memory deficits. Several compounds are being tested in attempts to prevent and/or cure Alzheimer's disease, including tacrine, which has very modest efficacy in a sub-group of patients, and new acetylcholinesterase inhibitors. Pilot experiments have also been launched using nerve growth factor (NGF) to prevent or stabilize the processes of cholinergic pathway degeneration. Alternatively, antioxidants, free radical scavengers and/or non steroidal anti-inflammatory agents may be screened as potential therapies for neurodegenerative diseases induced by multiple endogenous and/or exogenous factors. The recent use of transgenic mice, in parallel with other genetic, biochemical and neurobiological systems, in vivo and/or in vitro (cell cultures), should accelerate the discovery and development of specific drugs for the treatment of Alzheimer's disease.     

关于建构Windows 8风格图书馆主页的研究

图书馆主页是图书馆服务用户的重要平台,随着科技的进步和发展,图书馆主页需要积极主动地改变自己,增加图书馆在用户心中的价值,提高用户的忠诚度.结合相关研究文献、搜索引擎,通过对200多个大学图书馆及公共图书馆主页点击访问,揭示了图书馆主页运用Windows 8风格不多的现状, 探讨了建构Windows 8风格图书馆主页的流程及方法.