铝合金7175─T74环形锻件锻造工艺研究

通过对超硬铝合金 7175T74的试验研究 ,给出了 7175T74合金的锻造工艺参数 .依此工艺生产的锻件其性能达到美国宇航材料规范AMS4149A规定的技术指标 .为工业化生产铝合金 7175T74环形锻件提供了颇有价值的借鉴     

东方田鼠抗日本血吸虫病CD74基因的差异表达及生物信息学分析

利用日本血吸虫尾蚴感染东方田鼠,提取感染前和感染后10d和15d东方田鼠肝脏组织总RNA;利用大鼠CD74基因探针,经Rorthern杂交分析东方田鼠感染日本血吸虫前及感染血吸虫10 d、15 d后肝脏组织CD74的差异表达情况;同时,采用生物信息学分析大鼠CD74基因的cDNA序列及其编码的氨基酸序列以及CD74蛋白的结构域.结果显示:东方田鼠感染日本血吸虫感染血吸虫10 d、15 d后肝脏组织CD74的表达水平比感染前显著升高;大鼠CD74基因的cDNA序列全长1220bp,编码216个氨基酸残基;大鼠CD74蛋白含一个MHC2相互作用超家族结构域和一个MHCassoc_trimer超家族结构域.     

动态扫描显示电路实验的设计与实现

动态扫描显示技术已被广泛应用。为深入理解其工作原理，结合乐山师范学院物理与电子信息科学系实验条件，设计了一套简单有效的实验电路，并说明了具体设计和实现方式。该设计对数字电路综合性、设计性实验的开发是一次成功尝试。     

微机预付费电能表驱动控制系统的设计

该文介绍了微机控制预付费电能表的驱动控制系统的设计及 BH30 2 3,74 L S14 5芯片在该系统中的应用 ,并讨论了驱动控制程序的设计 .     

α-1,3-Fucosyltransferase-VII stimulates the growth of hepatocarcinoma cells via the cyclin-dependent kinase inhibitor p27Kip1

After the transfection of 74gywg6nj81xnl/xxlarge945.gif" alt="agr" align="BASELINE" BORDER="0">-1,3-fucosyltransferase (FucT)-VII cDNA into H7721 human hepatocarcinoma cells, the protein expression of some cyclins, cyclin-dependent kinases (CDKs) and cyclin-dependent kinase inhibitors (CDIs) p16^INK4 and p21^waf1/Cip1 were unchanged. However, CDI p27^Kip1 protein, both the total amount and the amount that bound to CDK2, but not its mRNA, was significantly reduced. The de-inhibited CDK2 stimulated the phosphorylation of retinoblastoma (Rb) protein and facilitated the G1/S transition and growth rate of the cells. The decrease of p27^Kip1 protein, the increase of CDK2 activity and Rb phosphorylation, as well as the cell growth and percentage of S phase cells were correlated to the increased amount of cell surface sialyl Lewis X (SLe^x) antigen in cells with different 74gywg6nj81xnl/xxlarge945.gif" alt="agr" align="BASELINE" BORDER="0">-1,3-FucT-VII expression. The reduction in p27^Kip1 and the difference in its expression among different transfected cells were blocked by the SLe^x antibody KM93 in a dose-dependent manner, indicating that p27^Kip1 expression was influenced by 74gywg6nj81xnl/xxlarge945.gif" alt="agr" align="BASELINE" BORDER="0">-1,3-FucT-VII and its product SLe^x. The MEK/MAPK signaling pathway was more important than the PI-3K pathway in the regulation of p27^Kip1 expression.Received 5 August 2004; received after revision 25 October 2004; accepted 11 November 2005