以德治国与学校教育管理

本文论述了学校贯彻以德治国的精神,学校在管理中特别要重视思想教育和道德建设,教师要率先垂范,要从爱的愿望出发去教育学生,以爱的手段方式去教育学生。     

关于增强校长培训实效性的课程研究

开展中小学校长培训 ,提高校长的整体素质 ,是我国教育可持续发展的一项重要决策。实践告诉我们 :如果只注重国家课程的开发而忽视参训校长本人的内心需求 ,这样的培训是低效的。比较好的做法是找到国家课程与参训校长所需课程的结合点 ,按需施教 ,将培训落到实处。应在国家课程的基础上开发来自于参培者本身需要的“校长本位”课程     

关于"与时俱进"的思考

江泽民同志指出“马克思主义具有与时俱进的理论品质”。这是对马克思主义时代品质和创新精神的揭示,也是对中国共产和我国人民的要求,它不但反映了现实实际和历史。而且对我们党努力创造,勇于开排,不断提高领导水平和执政能力及其抵御风险,驾驭大局的能力有极其重要的指导意义,我们只有对“与时俱进”全面,辩证地理解和思考,才能把现实工作做得更好。     

基于信息技术的企业组织激励研究

通过将信息技术水平系数纳入到委托代理模型中,创新地建立了基于信息技术的企业组织激励模型,模型分析结果表明,简单组织中监督系统的信息技术水平越高,底层员工报酬合同的激励作用越显著,复杂组织中,随着信息技术水平的提高,底层员工报酬合同的激励作用也增强,而中层管理者的激励作用会因为风险传递效应的存在而呈现出先增强后减弱的变化趋势,通过对组织代理成本的分析可知,在信息技术水平较低和较高时,简单组织和复杂组织分别具有“激励优势。”。     

高应力软岩巷道壁后充填支护研究

高应力软岩巷道属非线性大变形问题,巷道支护必须满足其变形要求。总结了白皎煤矿高应力软岩砌碹巷道变形破坏特征,分析了砌碹巷道破坏机理,并对碹体壁后充填粉煤灰基材料改善"支护-围岩"关系的作用机理进行了分析,最后得到了现场验证。     

CD1d and natural T cells: how their properties jump-start the immune system

Cellular and humoral immune mechanisms recruited to defend the host from infectious agents depend upon the early immune events triggered by antigen. The cytokine milieu within which the immune response matures is the most important of many factors that govern the nature of the immune response. Natural T cells, whose function is controlled by CD1d molecules, are an early source of cytokines that can bestow type 1 or type 2 differentiative potential upon helper T lymphocytes. This review attempts to illuminate the glycolipid antigen presentation properties of CD1d, how CD1d controls the function of natural T cells and how CD1d and natural T cells interact to jump start the immune system. CD1d is postulated to function as a sensor, sensing alterations in cellular lipid content by virtue of its affinity for such ligands. The presentation of a neo-self glycolipid, presumably by infectious assault of antigen-presenting cells, activates natural T cells, which promptly release pro-inflammatory and anti-inflammatory cytokines and jumpstart the immune system. Received 10 July 2000; received after revision 16 October 2000, accepted 16 November 2000     

小桥涵预制板改现浇的施工方法

文章从荷载横向分布机理,阐述如何将预制板梁改成现浇板梁,并提出了“预制工现浇”法。     

The generalized inverse of singular integral operators on an open arc and its applications

After choosing weight functions suitably, we define a Banach spaceH _ω ^μ (L) and discuss the generalized inverse of singular integral operators on an open arc. Using the generalized inverse, we obtain the solutions for the following singular integral equation

Role of Cys221 and Asn116 in the zinc-binding sites of the Aeromonas hydrophila metallo-β-lactamase

The CphA metallo--lactamase produced by Aeromonas hydrophila exhibits two zinc-binding sites. Maximum activity is obtained upon binding of one zinc ion, whereas binding of the second zinc ion results in a drastic decrease in the hydrolytic activity. In this study, we analyzed the role of Asn116 and Cys221, two residues of the active site. These residues were replaced by site-directed mutagenesis and the different mutants were characterized. The C221S and C221A mutants were seriously impaired in their ability to bind the first, catalytic zinc ion and were nearly completely inactive, indicating a major role for Cys221 in the binding of the catalytic metal ion. By contrast, the binding of the second zinc ion was only slightly affected, at least for the C221S mutant. Mutation of Asn116 did not lead to a drastic decrease in the hydrolytic activity, indicating that this residue does not play a key role in the catalytic mechanism. However, the substitution of Asn116 by a Cys or His residue resulted in an approximately fivefold increase in the affinity for the second, inhibitory zinc ion. Together, these data suggested that the first zinc ion is located in the binding site involving the Cys221 and that the second zinc ion binds in the binding site involving Asn116 and, presumably, His118 and His196.Received 3 March 2003; received after revision 4 August 2003; accepted 25 August 2003