新试剂CPAH—Ⅰ的合成,纯化及与铍离子显色反应的研究

该文首次报道了新显色剂－氨基－２－（４－氯－２－膦酸基苯偶氮）－１－－羟基－３，６－萘二磺酸（ＣＰＡＨ－Ⅰ）的合成，纯化，结构鉴定及其与铍离子的显色反应。在所拟定的条件下，铍离子与试剂形成稳定的紫红色配合物，且发色迅速，选择性好，是一个频有应用价值的新的测铍试剂。     

水口参数对异形坯连铸结晶器内流场的影响

依据湍动能理论,本文建立了结晶器内钢液的三维湍流模型,开发了计算程序,研究了不同水口状态下异形坯结晶器中钢水的流动特性.利用本模型所得计算结果与实测结果吻合较好,并可对现场生产进行离线分析.     

低温Al2O3悬浮电解新工艺的研究

A new process of low temperature Al2O3 suspension electrolysis for produc-ing aluminum in low melting point fluo-chloride system was investigated. Current efficiency (η) expres-sion deduced from experiments on 20～80A electrolysis cell showed that main effects on η are the cell current and the surface of aluminum produced．Increasing cell current and diminishing aluminum surface can both make η increase. On an electrolysis cell of about 100A capacity with the fine γγ-Al2O3 (media diam.1.22μm) and the mixture in which F－/C1－molar ratio was 1 at 750℃，aluminum metal was obtained with 86.3% current efficiency and 11.73kWh specific energy consumption.     

LnCl3／MCl熔盐体系能量不对称性（Ln=稀土元素,M=碱金属元素）

ＬｎＣｌ３／ＭＣｌ熔体中，库仑效应，ＶａｎｄｅｒＷａａｌｓ效应和极化效尖起着主导作用，导致溶液热力学性质对相理想溶液中负偏差，并在ｘＬｎＣｌ≈０．２处，形成最大有序，用扩展的似化学理论模型能较好的描述这一特点，阐述了发展新热力学模型时应考虑到次近邻粒子及诸如空穴等似离子的作用，结合熔体结构研究，探讨熔体热力间的相互作用机理。     

软岩隧道建造过程三维有限元仿真分析

根据地下隧道施工不同的开挖程序和锚固施工方法，运用三维有限元数值分析方法模拟地下隧道施工建造过程，以期寻找有利于围岩稳定的开挖和支护方式。依据岩体破坏特性和弹塑性力学应变能原理，给出了隧道开挖的优化指标和方法，并以此得到较优的施工方案。     

连片叠前深度偏移处理技术在孤西地区的应用

孤西断裂带地质构造十分复杂,速度横向变化较大,该区已进行了三维连片处理,但潜山的构造背景及准确细致的构造形态仍不清楚,制约了对该区带的深入地质研究和评价。采用匹配滤波、叠前数据规则化等技术对叠前连片道集进行精细处理后,再进行叠前深度偏移迭代,并利用层析成像法对层速度模型进行校正,成像剖面信噪比较高、潜山归位准确,内幕清楚,发现和落实了多个圈闭构造。     

NaHSO3对草莓生理学的影响

在草莓花期喷施２００ｍｇ．Ｌ＾－１的光呼吸抑制剂ＮａＨＳＯ３，经测试，草莓植株叶绿素含量增加，光合速率增强，比叶重提高，硝酸还原酶活性受抑制，单果重增加。草莓果实品质明显改善，可溶性总糖含量增加２１％，提早成熟４－７天，亩产量增加１２％。     

基于Unity3D的智能家居综合管理平台的研究与实现

利用Unity3D技术,对智能家居综合管理平台进行了优化,可根据用户的实际需要对空间进行建模,放弃了传统的二维平面管理平台,利用Unity3D对所需模型进行建模并且在所建立空间模型中实现了漫游,用户可对空间视野范围内的可控单元进行操作,实现了多目标实时控制.同时,虚拟现实技术其自身的特性增加了用户在使用时的沉浸感和互动性.     

Metformin targets liver tumor-initiating cells through the PI3K/Akt/mTOR survival pathway

Liver tumor-initiating cells （T-ICs） are thought to be inherently resistant to the cytotoxic effects of chemo- therapy, and can self-renewal and maintain tumor-initiating potential. Therefore, effective anticancer research strategies should target the unique properties of T-ICs. In this study, we found that metformin, a first-line drug of choice for the treatment of type 2 diabetes, inhibited liver T-ICs both in vivo and in vitro. Metformin inhibited the formation of hepato- spheres and epithelial-specific antigen-positive （ESA, CD133＋） cell colonies by hepatocellular carcinoma （HCC） cell lines. Metformin also downregulated the expression of several T-IC-related genes which are involved in the signal- ing pathways, governing the self-renewal, proliferation and differentiation of T-ICs. Furthermore, the targeting of liver T-ICs by metformin was PI-3-kinase-Akt-mTOR （PI3K/Akt/ mTOR）-pathway dependent. The PI3K/Akt/mTOR inhibitorLY294002 and rapamycin abolished the inhibitory effect of metformin on CD133＋ cells, and the PI3K/Akt/mTOR stimulator EGF promoted the inhibitory effect of mefformin on CD 133＋ cells. Metformin also dramatically decreased the tumor volume and number of CD133 expressing tumor cells in a xenograft mouse model. Mefformin exerted a synergistic effect with cisplatin to target both T-ICs and non-T-ICs, and resulted in the smallest tumor volume and lowest number of CD133 expressing tumor cells. This study indicates that the antidiabetic drug metformin could potentially be used in combination therapy with chemotherapeutic agents to improve the treatment of liver cancer.     

无线通信网络发展趋势研究与分析

从技术和应用角度分析了3G网络的关键技术和特点,研究了3G与WLAN融合建网的可能性、必要性、主要技术和网络的结构,讨论了下一代无线网络的发展方向和趋势。