钛酸铋的热力学理论

利用点群４／ｍｍｍ的对称性给出了应力作用下的钛酸铋的弹性吉布斯自由能的表达式，并导出了自发应变，介电性质和压电性质。     

45钢固体粉末法稀土、硼、铬、铝共渗工艺研究

研究了RE_Mg合金对固体粉末法硼、铬、铝共渗层成分、组织和性能的影响 .发现随着RE_Mg合金加入量的增加 ,渗层中Al2 O3的量不断增多 ,当RE_Mg合金加入量为 5 %时 ,渗层中出现连续致密分布的Al2 O3黑区组织 ,对此进行了性能测试和机理探讨     

具粘性双曲型方程组解的整体存在性

对于具粘性双曲型方程组Cauchy问题，通过引进Lax熵-熵流对的方法，得到了解的整体存在性，利用补偿紧致的方法证明了L∞逼近解的收敛性.     

立体构成与现代服装造型设计的关系

面的回转会产生立体，服装造型可以说就是面料按结构组合与面回转的原理形成的立体形态。此文通过立体构成与服装造型设计上的关系，阐明立体构成对服装造型设计的影响与作用。     

诺氟沙星——铽（Ⅲ）与核酸的相互作用研究及其应用

研究了诺氟沙星—铽(Tb^3 )络合物与核酸(DNA)的相互作用，据此建立了核酸的测定方法，讨论了诺氟沙星—铽与DNA分子之间的结合方式。     

Banach空间中一类强非线性发展方程的反周期解

本文讨论一类强非线性发展方程的反周期解的存在性。针对一大类既含有单调非线性算子又含有非单调非线性算子的发展方程。我们巧妙地结合单调算子理论与Leray-Schauder不动点理论，证明了其反周期解的存在性。最后，举例说明理论结果在2m阶拟线性抛物型方向的时间反周期问题中的应用。     

具有时滞的非自治的Lotka-Volterra生态系统的全局稳定性

考虑一个具有时滞的非自治的捕食——食饵生态系统。该系统是由一个捕食，二个食饵种群所构成我们给出了系统的周期解是全局稳定的充分条件。     

Science Letters： A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors （TLRs） plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 （TLR2） ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen （HDM）. Mice were sensitized and challenged with Dermatophagoidesfarinae allergen （Der f）, and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid （BALF）. Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

Specific anti-tumor effect induced by attenuated Salmonella typhimurium vaccine expressing extracellular region of vascular endothelial growth factor receptor 2

The purposes of this research were to study the stable expression of exogenous gene encoding therapeutic protein in attenuated Salmonella typhimurium, observe the metabolism of oral gene vaccine carried by attenuated Salmonella typhimurium in BALB/c mouse, and investigate the feasibility of prevention and treatment of tumors by the recombinant bacteria. Recombinant plasmid pcDNA3.1 VEGFR2(n1-7) was transformed into competent attenuated Salmonella typhimurium SL3261 to develop oral DNA vaccine SL3261-pcDNA3.1 VEGFR2(n1-7). To observe whether the exogenous gene can be expressed in the recombinant bacteria, PCR was performed to amplify the CMV promoter of the eukaryotic expression vector as the proof of stable expression of exogenous protein; transmission elec- tron microscopy (TEM) was applied to observe the morphology of the recombinant bacteria to confirm that the exogenous gene has no impact on the growth of the bacteria, and then BALB/c mice were immunized with the gene vaccine. After inoculation of the gene vaccine, the recombinant bacteria SL3261 could be detected in the tissues such as small intestine, colon, liver and spleen. And then, mice in each group were challenged with tumor cells. The results of animal experiment showed that tumor growth of the mice in experimental group was inhibited and survival time of immunized mice was prolonged compared with control groups. A higher lymphocyte infiltration in tumors from animals treated with DNA vaccine was observed. Immunohistochemical analysis of tumor samples revealed an en- hanced accumulation of CD8 cytotoxic T lymphocytes, as well as an increase in CD4 cells in the tumors of animals treated with the oral gene vaccine compared to tumors from control group mice. Ultrastructure of the tumor tissue showed that tumor cells in the samples of the immunized mice were well-differentiated. Our research confirmed that the exogenous gene can be stably expressed in the attenuated Salmonella typhimurium and has no impact on the growth of the recombinant bacteria; the exogenous gene can de delivered to the host by attenuated Salmonella typhimurium to produce anti-tumor effect with no obvious cytotoxity to the host. In this study, it is established that attenuated Salmonella typhimurium could be used as a vector for oral gene vaccine, and our study provided a theoretical basis for the body distribution and the metabolism of the recombinant bacteria. This strategy may provide a simple, safe and effective way for the prevention and treatment of tumors.