湖南山丘区景观生态系统退化特征初探

湖南山地丘陵面积约占全省土地总面积的２／３，是省域最重要的景观生态系统类型。自然状态下，湖南山丘区景观生态系统中景观组分性质优良，景观要素组合协调，景观生态过程稳定，景观功能较强。然而，在长期的人类活动影响之下，湖南山丘区景观生态系统显现出明显的退化特征，具有表现为景观要素组合关系改变、景观组分性质劣化、景观生态过程逆转、景观生态系统抗性降低。     

45钢固体粉末法稀土、硼、铬、铝共渗工艺研究

研究了RE_Mg合金对固体粉末法硼、铬、铝共渗层成分、组织和性能的影响 .发现随着RE_Mg合金加入量的增加 ,渗层中Al2 O3的量不断增多 ,当RE_Mg合金加入量为 5 %时 ,渗层中出现连续致密分布的Al2 O3黑区组织 ,对此进行了性能测试和机理探讨     

西部地区工矿区域城市化问题初探

城市化是一种极为普遍的现象 ,矿业地区的城市化研究成果在西部地区非常少见 ,现以云南省东川市为例 ,对其发展的现状特征进行分析研究 ,将其城市化分为两个阶段 ,并揭示西部地区城市化的基本动力、地区差异性等特征 ,可为此类城市的发展提供思路     

豫西丘陵区不同氮、钾肥用量配施对豫麦47号品质和产量的影响

在该试验条件下 ,豫麦 47号的湿面筋含量平均为 2 8.3%,吸水率、面团形成时间、稳定时间分别为 6 3.2 %、3.9分钟和 4.2分钟 ,与豫麦 47号适生区栽培条件下均有较大差异。氮肥可有效提高豫麦 47号的冬前分蘖、亩有效穗数和湿面筋含量 ,钾肥可提高亩穗数和千粒重。     

加快三峡库区移民市民化进程的对策思考

推动三峡库区农村移民市民化进程,一要发挥政府在三峡库区城镇化过程中农民市民化的主导作用;二要发挥社会力量和非政府组织在农民市民化中的支撑作用;三要大力发展绿色环保工业和第三产业,使之成为农村移民市民化的有效载体;四要引导移民加强学习,增强其在市民化过程中的自动性.     

Science Letters： A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors （TLRs） plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 （TLR2） ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen （HDM）. Mice were sensitized and challenged with Dermatophagoidesfarinae allergen （Der f）, and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid （BALF）. Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

激光光束质量的评价方法

激光光束质量是一个很有现实意义的论题，对不同应用的激光光束其质量的评价标准一般不同。给出了几种有代表性的激光光束质量的评价方法，并分别对各种评价标准的合理性与适用性进行了详细的分析；研究了实际应用中对激光光束质量的一些要求和相关的评价参数。     

工程哲学与神东亿吨矿区创新实践

工程哲学指导工程实践。神东矿区在煤矿开发建设创新实践中遵循“系统性、客观性、时效性”的理性思维，系统思考，整体推进，寻找主客观最佳结合，及时掌握和集成新技术、新材料、新装备、新工艺，建设了不同于传统模式的千万吨矿井，建成世界上首个亿吨级煤炭生产基地。全员工效、生产规模、安全、环保水平、资源回收率等指标达到国际领先水平。     

Specific anti-tumor effect induced by attenuated Salmonella typhimurium vaccine expressing extracellular region of vascular endothelial growth factor receptor 2

The purposes of this research were to study the stable expression of exogenous gene encoding therapeutic protein in attenuated Salmonella typhimurium, observe the metabolism of oral gene vaccine carried by attenuated Salmonella typhimurium in BALB/c mouse, and investigate the feasibility of prevention and treatment of tumors by the recombinant bacteria. Recombinant plasmid pcDNA3.1 VEGFR2(n1-7) was transformed into competent attenuated Salmonella typhimurium SL3261 to develop oral DNA vaccine SL3261-pcDNA3.1 VEGFR2(n1-7). To observe whether the exogenous gene can be expressed in the recombinant bacteria, PCR was performed to amplify the CMV promoter of the eukaryotic expression vector as the proof of stable expression of exogenous protein; transmission elec- tron microscopy (TEM) was applied to observe the morphology of the recombinant bacteria to confirm that the exogenous gene has no impact on the growth of the bacteria, and then BALB/c mice were immunized with the gene vaccine. After inoculation of the gene vaccine, the recombinant bacteria SL3261 could be detected in the tissues such as small intestine, colon, liver and spleen. And then, mice in each group were challenged with tumor cells. The results of animal experiment showed that tumor growth of the mice in experimental group was inhibited and survival time of immunized mice was prolonged compared with control groups. A higher lymphocyte infiltration in tumors from animals treated with DNA vaccine was observed. Immunohistochemical analysis of tumor samples revealed an en- hanced accumulation of CD8 cytotoxic T lymphocytes, as well as an increase in CD4 cells in the tumors of animals treated with the oral gene vaccine compared to tumors from control group mice. Ultrastructure of the tumor tissue showed that tumor cells in the samples of the immunized mice were well-differentiated. Our research confirmed that the exogenous gene can be stably expressed in the attenuated Salmonella typhimurium and has no impact on the growth of the recombinant bacteria; the exogenous gene can de delivered to the host by attenuated Salmonella typhimurium to produce anti-tumor effect with no obvious cytotoxity to the host. In this study, it is established that attenuated Salmonella typhimurium could be used as a vector for oral gene vaccine, and our study provided a theoretical basis for the body distribution and the metabolism of the recombinant bacteria. This strategy may provide a simple, safe and effective way for the prevention and treatment of tumors.     

急倾斜厚煤层掩护支架采煤法机械化问题的探讨

掩护支架采煤法是开采急倾斜厚煤层的有效方法之一,但回采工艺大多使用炮采。为进一步扩大急倾斜厚煤层掩护支架采煤法的适用范固,大幅度地提高技术经济效果,必须实现掩护支架下的采煤机械化。本文在总结分析国内外有关经验、资料的基础上,对掩护支架结构型式的改进和采煤机械化问题进行了初步的探讨,提出了设想方案。