AP121在大鼠体内的组织分布研究

研究试图建立抗抑郁新药AP121在大鼠体内主要脏器组织的药物浓度检测方法,并探究其在大鼠体内的分布规律. 选用健康SPF级SD大鼠24只,随机分为A、B、C3组,每组8只,雌雄各半,每组中随机选择1只大鼠作为空白对照（0 h）,其他7只按19.32 mg·kg?1灌胃给予AP121 Labrasol溶液后于1、4、9 h采集心脏、肝脏、脾脏、肺脏、肾脏组织样本,采用HPLC-MS/MS法检测5种脏器组织中AP121的浓度. 结果显示,1、4、9 h 3个时间点5种组织中的AP121浓度分布分别为:肝脏>肺脏>心脏>脾脏>肾脏,肺脏>肝脏>心脏>脾脏>肾脏,肝脏>肺脏>心脏>脾脏>肾脏;AP121在肺脏、心脏及肝脏中浓度个体差异大;肝脏中的AP121在1 h达最高浓度,其它4种脏器组织中AP121均在4 h达最高浓度,9 h各组织中的浓度大幅下降,且低于1 h时. 分析结果表明,所建立的LC-MS/MS法测定大鼠5种主要脏器中AP121的分析检测灵敏、准确、可靠,可为该药系统的药代动力学评价提供技术支持;肝脏和肺脏可能是AP121的代谢转化器官或作用的靶器官,后续药物开发过程中,需关注药物对肺脏、心脏及肝脏的个体影响差异,且需重点关注药物对于肝脏和肺脏的影响.     

Molecular genetic basis for the rhino mouse from Chinese KM subcolony

Both the rhino mouse and hairless mouse resulted from hairless gene mutation, but they show different phenotypes of skin physiology. The rhino mouse has more similar histological characters to human papular alopecia.Therefore rhino mouse is a good experimental animal model for human papular alopecia. This study reports a hairless mouse named rhino KIZ, arose from KM colony in Kunming Institue of Zoology, by systematic studies on morphology,skin histopathology, gene sequence, pedigree and protein domain analysis. The results demonstrate that a C-to-T transition in exon 11 of hr gene (The mutant gene has been applied for a Chinese patent (patent No. 03135280)) results in the rhino KIZ. The rhino KIZ with clear genetic mechanism will be a useful animal model.     

An early cretaceous<Emphasis Type="Italic">Ginkgo</Emphasis> ovule-bearing organ fossil from Liaoning,Northeast China and its evolutionary implications

Ginkgo is a very important gymnospermous genus that has only one surviving species, Ginkgo biloba L. As a so-called “living fossil“, wild Ginkgo was found only in China, but it once flourished well and had a world-wide distribution in the Mesozoic. The earliest Ginkgo has been known from the Middle Jurassic, based on ovule-bearin gorgans. In the Jurassic and Early Cretaceous, Ginkgo was one of the dominant gymnosperms in floras and possibly one of the coal-forming plants in North China. During the Early Tertiary, it reduced to a circumpolar distribution in the North Hemisphere; only a few reported from the South Hemisphere. From the Pliocene onwards, the Ginkgoales has been represented by the extant monotypic “living fossil“ Ginkgo biloba.     

黄瓜病虫害诊断专家系统知识组织的研究与设计

针对黄瓜病虫害的特点和特征描述,利用产生式-特征表结合的表达方式、模糊逻辑和可能性理论,对黄瓜病虫害诊断的知识组织进行研究,解决了黄瓜病虫害诊断过程中的症状表现的偶然性和差异性。该研究对于开发一系列的蔬菜病虫害诊断专家系统有很好的应用和参考价值。图1,表1,参10。     

Graph rigidity and localization of multi-robot formations

This paper provides theoretical foundation tor the problem ot localization in multi-robot formations. Sufficient and necessary conditions for completely localizing a formation of mobile robots/vehicles in SE(2) based on distributed sensor networks and graph rigidity are proposed. A method for estimating the quality of localizations via a linearized weighted least-squares algorithm is presented, which considers incomplete and noisy sensory information. The approach in this paper had been implemented in a multi-robot system of five car-like robots equipped with omni-directional cameras and IEEE 802.11b wireless network.     

组织的系统结构定义探讨

为了解释现实中存在的,有着相同的组织部门结构却有着不同的功能,似乎与“系统的结构决定其功能”的系统原理相矛盾的现象,在肯定结构决定功能的系统原理、在系统结构的一般定义以及切克兰德的系统分类的基础上,借鉴有关悖论的智能,提出了“系统的类型不同,共结构的具体定义也应不同”的观点,由此得出了直接移植“被设计系统”的结构定义到组织导致了上述矛盾的结论,并进一步给出了作为“人类活动系统”的组织的结构定义,还用案例对这个定义的意义做了说明。     

建立教育实习导师制提高教育实习质量

文章从提高教育实习质量的角度出发,结合目前高等教育的改革与发展,分析本院现有教育实习的组织模式之不足,主张与中学真诚合作,建立和完善教育实习的导师制,并有目标地协调好"指导教师、实习教师、学生"三者之间的合作关系,从而达到提高教育实习质量之目的.     

任务导向与员工导向:一项关于国营企业和中外合资企业领导风格的比较研究

文章对中国国营企业和中外合资企业的领导风格进行了比较研究。采用一种在西方广泛使用的测量领导风格的调查问卷,对410名国营企业和中外合资企业的员工进行了问卷调查。这些问卷的统计分析结果显示出两种不同的领导风格：“任务导向”和“员工导向”。国营企业有着更强有力的“任务导向的领导”,而中外合资企业存在着更强有力的“员工导向的领导”。     

基于信息技术的企业组织激励研究

通过将信息技术水平系数纳入到委托代理模型中,创新地建立了基于信息技术的企业组织激励模型,模型分析结果表明,简单组织中监督系统的信息技术水平越高,底层员工报酬合同的激励作用越显著,复杂组织中,随着信息技术水平的提高,底层员工报酬合同的激励作用也增强,而中层管理者的激励作用会因为风险传递效应的存在而呈现出先增强后减弱的变化趋势,通过对组织代理成本的分析可知,在信息技术水平较低和较高时,简单组织和复杂组织分别具有“激励优势。”。