<Emphasis Type="Italic">In situ</Emphasis> synthesis of TiC reinforced Cu<Subscript>47</Subscript>Ti<Subscript>34</Subscript>Zr<Subscript>11</Subscript>Ni<Subscript>8</Subscript> bulk metallic glass composites

In situ synthesized TiC particles and β-Ti dendrites reinforced Cu47Ti34Zr11Ni8 bulk metallic glass (BMG) composite ingots were prepared by the suction casting method.The ingots with diameters from 1 up to 4mm were successfully obtained. It was shown that introducing TiC micro-sized particles into the amorphous matrix did not disturb the glass forming ability (GFA) of the matrix,while the yield strength and ductility could be well improved.The phase constitution, microstructure and elements distribution in the composites were studied by OM, XRD, SEM and EDS.It was shown that the in situ synthesized TiC particles acting as heterogeneous nucleation sites promoted the precipitation of β-Ti dendrites, resulting in the formation of the TiC particles and β-Ti dendrites co-reinforced BMG composites. The compressive tests were employed to probe the yield strength and ductility of BMG composites.     

Permeation study of the potassium channel from streptomyces Lividans

A three-state hopping model is established according to experiments to study permeation of an open-state potassium channel from Streptomyces Lividans (KcsA potassium channel). The master equations are used to characterize the dynamics of the system. In this model, ion conduction involves transitions of three states, with one three-ion state and two two-ion states in the selectivity filter respectively. In equilibrium, the well-known Nernst equation is deduced. It is further shown that the current follows Michaelis-Menten kinetics in steady state. According to the parameters provided by Nelson, the current-voltage relationship is proved to be ohmic and the current-concentration relationship is also obtained reasonably. Additional validation of the model in the characteristic time to reach the steady state for the potassium channel is also discussed. This model lays a possible physical basis for the permeation of ion channel, and opens an avenue for further research.     

Regulation of BMP4 on the proliferation and differentiation in SVZa neural stem cells

The neural stem cells in the anterior subventricular zone (SVZa) mainly generate the progenitors that will differentiate into neurons, and along a highly circumscribed migratory access Rostral migratory stream (RMS), they migrate to the olfactory bulbs (OB). To understand the effects of BMPs on SVZa neural stem cells, in this study BMP4 at various concentrations was used to induce SVZa neural stem cells, and the living cell labeling using BMP4 promotor conjugated with red fluorescence protein showed the expression of BMP4 dynamically. The results demonstrated that low BMP4 doses (1-5 ng/mL) promoted while high doses (10-100 ng/mL) inhibited the proliferation of SVZa neural stem cells, and BMP4 promotedneuron differentiation in the early stage (1-3 d), howeverm, it inhibited the neuron commitment after 4 d. Noggin, the antagonist of BMP4, blocked the physiological effects of BMP4. In OB, BMP4 is mainly to accelerate the progenitors to withdraw from the cell cycle and trigger the differentiation, and in RMS, it promotes the proliferation of committed progenitors and not differentiation, further in SVZa, BMP4 enhances astrocyte commitment.     

Homoharringtonine induces apoptosis of endothelium and down－regulates VEGF expression of K562 cells

Homoharringtonine (HHT) has currently been used successfully in the treatment of acute and chronic myeloid leukemias and has been shown to induce apoptosis of different types of leukemic cells in vitro. Emerging evidence suggests that angiogenesis may play an important role in hematological malignancies, such as leukemia. However, whether HHT can relieve leukemia by anti-angiogenesis is still unknown. We investigated the anti-angiogenesis potential of HHT with the human umbilical vein endothelial cell line (ECV304) and leukemic cell line (K562) in vitro. Cellular proliferation was determined by MTT assay and apoptosis was analyzed by flow cytometry, The mRNA expression of vascular endothelial growth factor (VEGF) was assessed by RT-PCR and VEGF protein production was detected by Western blot. Inhibition of cell proliferation and induction of apoptosis by HHT were discovered in ECV304 cells, and appeared in a dose- and time-dependent manner, Also, treatment with HHT caused down-regulation of VEGF mRNA expression in K562 cells in similar dose- and time-dependent manner and inhibition of VEGF protein production in K562 cells in response to the enhancing concentration of HHT. The results demonstrated that HHT could also induce apoptosis in endothelium and down-regulate VEGF expression in K562 cells. In conclusion, we believe HHT has anti-angiogenesis potential and speculate that HHT might exert its anti-leukemia effects via reduction of angiogenesis.     

ISA-YMG粗铅冶炼新工艺

评述了铅提取技术的历史及现代铅提取技术的特点;针对我国目前粗铅冶炼现状,结合对高铅渣冶炼的多年研究,提出一种高效、节能、清洁的ISA-YMG粗铅冶炼新工艺,并提供了YMG还原熔炼工业试验结果。     

以情感人 以情育人

新初中语文教学大纲除了强调语言学科的工具性外,大力强调了语言学科的人文性。语文教材具 有丰富的思想内容,每篇文章都寄托着作者的思想感情。因此,在阅读教学中,必须挖掘和体会课文的情感因 素,把一篇篇有血有肉的文章讲得情景交融,达到"情融融,意切切"的境界。教学过程中的一切活动都是以富有 情感的学生作为主体,学习主体对知识的掌握以及由知识向智能的转化,无不借助于具有动力因素的情感媒介 来实现。为了使学生披文入境,入境动情。教师必须钻研教材,把握教材情感基调。教学中,学生被浓厚的情感 渗透,产生强烈的情绪活动,从而有效地增强课堂教学效果。     

PBG光子晶体光纤中空气导光条件的研究

应用平面波法分析了带隙效应导引光子晶体光纤(Photonicbandgapguidingfibers,PBG PCFs)中实现空气通道导光必须满足的条件,计算机仿真了蜂窝和三角形两种不同结构的PBG PCFs的空气导光性能。计算结果表明,要实现空气导光,空气孔直径与周期的比值d/Λ必须大于某一特定值:对于蜂窝结构该比值为0.84,而对于三角形结构该比值为0.59;在特定的d/Λ下,空气导光的波长范围随Λ可变。     

克拉2气田石油地质特征

克拉2气田位于库车拗陷克拉苏构造带中段, 是双重构造中呈串珠状分布的一系列褶皱中的一个局部构造. 含气层系以下白垩统巴什基奇克组砂岩为主, 其次为下第三系库姆格列木群白云岩段和砂砾岩段及下白垩统巴西盖组砂岩. 天然气中甲烷含量大于97%, 属于干气, 气源为侏罗系煤系地层. 克拉2号构造圈闭形成于西域期, 成藏期晚. 下第三系厚层膏盐区域盖层形成的良好封盖条件及其成藏期晚是克拉2大气田得以很好保存的根本原因. 克拉2气田的异常高压是由于西域期来自北部的强烈构造挤压作用而形成的.     

黄骅盆地孔西构造带的构造演化特征

通过平衡剖面技术复原古构造演化 ,并结合区域构造分析 ,可将孔西构造带的发育过程大致分为三个构造变形阶段 :晚三叠世末期为挤压褶皱变形期 ;晚三叠世沉积后至侏罗系沉积前为逆冲构造变形期 ;早—中侏罗世为逆冲构造“轻度”渐进变形期。晚侏罗世以后 ,区域构造作用发生反转。随着晚侏罗—早白垩世、早第三纪裂陷盆地的发育 ,孔西构造带作为潜山构造被掩埋。裂陷盆地时期的伸展构造对孔西构造带前第三系的逆冲构造基本上没有大的改造     

高应力软岩巷道壁后充填支护研究

高应力软岩巷道属非线性大变形问题,巷道支护必须满足其变形要求。总结了白皎煤矿高应力软岩砌碹巷道变形破坏特征,分析了砌碹巷道破坏机理,并对碹体壁后充填粉煤灰基材料改善"支护-围岩"关系的作用机理进行了分析,最后得到了现场验证。