ESR1基因多态性能影响慢性乙型肝炎的发病风险

军事医学科学院贺福初院士课题组与国家人类基因组北方研究中心等单位的国内同行合作 ,在对 2 0 2 5名乙型肝炎患者和 2 93个乙型肝炎核心家系的规模化分析后发现 ,ESR1基因上的T2 9C多态性能增加乙型肝炎慢性化的风险。这一发现证实ESR1基因是研究乙型肝炎慢性化的潜在靶标。相关研究论文发表在 2 0 0 4年 8月 13日Hepatology ,4 0 (2 ) :318—32 6上。该领域的国际著名权威、英国伦敦帝国大学的MarkThursz教授在同期杂志上撰写述评认为“这是一项在多个方面皆引人注目的研究”。慢性乙型肝炎是我国最常见的病毒性传染病 ,我国约有 1.…     

p53蛋白两种作用之间的关系

据英国Nature，2006，443：159报道．p53蛋白是脊椎动物DNA损伤响应和肿瘤抑制的一个重要调控因子．原先的研究认为这两种作用是有因果关系的．但最新研究数据却表明了与之相反的结果。     

Synthetic Study on Polyhydroxyestrogens Modeled for Inagami-Tamura Endogenous Digitalis-like Factor and Their Activity

1 Results Mammalian possess receptors for digitalis,cardiac glycosides,derived from plants.As one of the results from studies on a real endogenous ligand for the receptors,so called an endogenous digitalis-like factor (EDF) or substance (EDS),Inagami and Tamura isolated a promising candidate possessing a molecular weight,336.We elucidated several possible structures (Fig.1) for the factor and synthesized several modeled compounds,some of which exhibited remarkable constriction at higher concentrations t...     

记忆形成之谜

很久以来，科学家们就认为，用于构筑记忆电路的神经元是一种不可再生的资源，我们每一个人获得的细胞数量都是有限的。而且细胞的供应量每一年都在减少，所以，人到中年记忆便模糊不清，而且要学习新东西也越来越困难。但是，新的实验结果已经使这些旧观念开始动摇了。     

扩频调制技术在开关电源设计中的应用

介绍了多相扩频振荡器LTC6902的原理,并将其应用于开关电源中,以提高开关电源的EMC性能。     

松螺栓连接的可靠性设计

从实例出发,论述了松螺栓连接的可靠性设计。     

Investigations on the Sensing Mechanism of Humidity Sensors Based on Poly(4-vinylpyridine)/carbon Black Composite by AC Impedance Spectra

1 Results Investigations on the sensing mechanism is important for understanding the electrical responses of humidity sensors to humidity change,and could provide guidelines for the design and synthesis of humidity sensitive materials with desirable properties.In this work,the sensing mechanism of humidity sensors based on quaternized poly(4-vinylpyridine) (PVP)/carbon black (CB) composite[1] was studied by measuring their AC impedance spectra at various humidities at room temperature.Under low humidity...     

为什么有的人耳朵可以动？

动耳朵和卷舌头一样都是遗传。人类的三块耳外肌已经退化，从前的人也许可以像其他灵长动物一样，用扇动耳朵，绷紧前额来威吓敌人。虽然我们不需要像狼那样移动耳朵朝向声源，但有些人确实可以通过收缩耳后肌拉动耳朵。     

电力企业人力资源开发存在的问题及对策

电力生产企业是技术密集型企业,具有经营型、社会公益型的双重特点。多年来,在传统的计划经济体制下,电力企业虽然对人力资源的定量研究已经有了相当长的历史,但是这种定量分析始终局限于人力资源本身的数量特征上,未能涉及人力资源更重要的特征,即其质量特征。其根     

PEAK COVARIANCE STABILITY OF A RANDOM RICCATI EQUATION ARISING FROM KALMAN FILTERING WITH OBSERVATION LOSSES

We consider the stability of a random Riccati equation with a Markovian binary jump coefficient. More specifically, we are concerned with the boundedness of the solution of a random Riccati difference equation arising from Kalman filtering with measurement losses. A sufficient condition for the peak covariance stability is obtained which has a simpler form and is shown to be less conservative in some cases than a very recent result in existing literature. Furthermore, we show that a known sufficient condition is also necessary when the observability index equals one.