Finding finer functions for partially characterized proteins by protein-protein interaction networks

Based on high-throughput data, numerous algorithms have been designed to find functions of novel proteins. However, the effectiveness of such algorithms is currently limited by some fundamental factors, including (1) the low a-priori probability of novel proteins participating in a detailed function; (2) the huge false data present in high-throughput datasets; (3) the incomplete data coverage of functional classes; (4) the abundant but heterogeneous negative samples for training the algorithms; and (5) the lack of detailed functional knowledge for training algorithms. Here, for partially characterized proteins, we suggest an approach to finding their finer functions based on protein interaction sub-networks or gene expression patterns, defined in function-specific subspaces. The proposed approach can lessen the above-mentioned problems by properly defining the prediction range and functionally filtering the noisy data, and thus can efficiently find proteins’ novel functions. For thousands of yeast and human proteins partially characterized, it is able to reliably find their finer functions (e.g., the translational functions) with more than 90% precision. The predicted finer functions are highly valuable both for guiding the follow-up wet-lab validation and for providing the necessary data for training algorithms to learn other proteins.     

论黑白摄影的抽象与非现实

黑白摄影以其自身的独特性,在商业摄影界和艺术摄影界极具地位,主要是黑白这两种极色的不同组合产生的概括能力,赋予黑白摄影极强的抽象性,同时抽象性使黑白摄影剥离了色彩的真实,让照片本身的意义更加突出,以一种更直接、更质朴、更彻底的方式呈现在我们面前。而且他对客观事物的提炼、升华和再创造以黑、白、灰表现现实世界,注定是"非现实"的产物,而且永远是"非现实"的产物。     

地下区域动态传热研究

本文研究了地下区域非稳定传热，用拉式变换法求出地面吸热的理论s-传递函数，进而求出其理论频率响应特性。用频域回归方法求出地面吸热多项式s-传递函数，通过实例验证了多项式s-传递函数与理论传递函数的等价性，为更简单，高效地计算地下区域动态传热提供了一种新的思路。     

亚纯函数与其导数的公共Julia方向

本文研究不指定级的亚纯函数与其导函数的公共Julia方向的存在性问题。     

模和容量

本文论述了复平面内两个非交紧集的模与容量及环域的保形模是彼此一致的这一重要关系。     

特征结构提取的高阶Hopfield神经网络实现

本文首先建立了特征结构提取问题的罚函数表示，通过对罚函数求极小可以求得原始协方差矩阵的主特征向量及其对应的特征值。为了求得其他特征结构，特构造了一个协方差矩阵序列。如果将罚函数展开并进行整理，高阶Ｈｏｐｆｉｅｌｄ神经网络可被引入到特征结构提取中。这种方法比较直观，它将网络稳定时的输出与所求协方差矩阵的主特征向量的各个分量相对应，而网络稳定时的能量则对应于协方差矩阵的迹与所求特征值之差，计算机仿真结果验证了这种方法的正确性。     

周期函数的导函数的周期问题

本文将证明：在整个实轴上可微分的周期函数与其导函数的周期相同这一推测．     

非网络版软件在Novell网上运行环境的设计

本文通过对非网络版软件在单机上运行环境分析，找出了一套调整此类软件使其在Ｎｏｖｅｌｌ网上运行的方法，并提出了非网络软件在Ｎｏｖｅｌｌ网上运行环境的设计的观点，具有较大的意义。     

PbI_2－PbBr_2－KCl系统玻璃的形成及其析晶行为

ＰｂＩ_２可以单独形成玻璃。ＰｂＩ_２－ＰｂＢｒ_２－ＫＣｌ三元系统玻璃具有良好的玻璃形成能力。通过恰当的热处理，不仅可获得透红外性能与原始玻璃一致的微晶玻璃，同时还可克服自发析晶倾向和大幅度地提高玻璃的显微硬度。以此三元系统为基础，有望开发出一类具有实用前景的透红外玻璃材料。