浅谈近年艾滋病的研究进展

目前,艾滋病依然是人类无法攻破的绝症。近年来,经研究发现,HIV病毒的传播途径得到扩大,加上其突变率高,药物更新成为迫在眉睫的要求。本文总结了近年来艾滋病研究的进展,包括药物靶点的开发,疫苗的制作要求以及提出了具有研究前景的抗HIV相关的基因和蛋白,以引起关注。     

应用化学专业《药物化学》课程的教学改革与实践

结合理工类应用化学专业<药物化学>课程的特点,通过进行教学内容的改革、教学方法的改革、实践教学的改革、运用现代化的教学手段等一系列课程的教学改革与实践,达到培养高素质药学专业人才的目标.     

Studies on molecular interactions between puerarin and PC liposomes

Fluorescence emission spectra, FTIR spectra, zeta potential measurements, and ab initio quantum calculation are used to study the interaction between puerarin and membranes composed of egg phosphatidylcholine (PC) liposome. The hydrophobic interactions cause the puerarin molecule to partition into lipid bilayers with its B-ring, and favor the displacement of acid-base equilibrium of puerarin towards the base form. Due to the hydrogen bond formation between the puerarin hydroxyl groups and polar groups of PC molecules on the water/membrane interface, puerarin can easily intercalate into the organized structure of phospholipids and modulate the membrane function. Our results reveal that the liposome membrane integrity is significantly higher compared with that of empty liposome.     

Dialdehyde starch nanoparticles： Preparation and application in drub carrier

Dialdehyde starch nanoparticles (DASNP) were prepared by the redox reaction of NaIO4 and starch in water-in-oil microemulsion. IR spectrum showed that DASNP had aldehyde groups, and quantitative alkali consumption showed that its dialdehyde content was about (50±5)%. The average diameter of DASNP determined by SEM was about 100 nm. TGA-DTA showed that its thermal stability was better than starch nanoparticle (StNP) and dialdehyde starch (DAS). Its low biological toxicity was detected by cell experiment. Also the best mass ratio of doxorubicin (DOX) to combined DASNP detected by UV-VIS was 15 : 1, and the product was effective for controlled release of DOX. The cell experiment showed that the drug-carrier particle (DOX-DASNP) can release DOX for a long time and strengthened the effect of the anticancer drug. This work demonstrates that the DASNP, which has good thermal stability, small particle size, low biological toxicity, and slowly anticancer drug-releasing to strengthen drug effect, is a potentially useful carrier for anticancer drug.     

老年痴呆症的药物治疗进展

老年痴呆症（ＡＤ）是一种神经退行性疾病，至今病因未明，且尚无特效药，近年来，临床运用促智药、胆碱酯酶抑制剂、乙酰胆碱释放增强剂、ＮＳＡＩＤ、神经生长因子等药物，对改善症状、延缓疾病表一定的作用。此病的病因及药的治疗有待作更深入的研究 。     

治疗心血管病的毒气

硫化氢 设想一下当走进医院急诊室，映入眼帘的是挂着消毒洗手液、表面擦得一尘不染的墙壁，扑鼻而来的却是一阵臭鸡蛋味。这种视觉和嗅觉上的不协调可能会让人们感到不舒服，但在将来具有臭鸡蛋气味的有毒气体硫化氢很可能会成为医疗机构的常用药物。科学家在去10年间发现，     

吡喃酮类化合物定量构效关系研究

采用分子结构描述符对吡喃酮类化合物进行结构表征和抗人类免疫缺陷病毒(HIV)的活性预测,通过逐步回归(SMR)方法建立了分子结构描述符与活性之间的定量模型,取得了良好的结果,其模型相关系数R=0.985 7;继以留一法(LOO)进行交互检验,相关系数R=0.954 6,说明定量相关模型具有良好的稳定性和预测能力。     

浅谈我校药物分析课程教学改革

为提高应用化工专业学生的综合素质,为适应社会发展和企业用人的需求,在应用化工专业学生学习药物分析课程的过程中应注重教材内容的全面性、先进性、科学性与多种教学方式的应用和改革。在课堂教学过程中,要采用多种教学方式,比如启发式教学激发学生的学习兴趣,在实验教学中通过在教学内容和形式上合理、科学的安排,培养学生独立思考问题、分析问题和解决问题的能力。     

几种名优水产养殖用药禁忌(上)

鳜鱼 鳜鱼对敌百虫、孔雀石绿、硝酸亚汞、福美砷、氯化铜等较敏感,前3种药物浓度超过0.2 mg/kg以上就会造成鳜鱼不同程度的死亡;1.5 mg/kg以上的福美砷,0.7 mg/kg以上(pH＜7)氯化铜也能造成鳜鱼中毒死亡.因此,在鳜鱼池中不宜使用这些药物.     

一位70后的技术总监和她的心里话——访2009年启明星计划入选者何训贵博士

<正>十几至几十个人的规模、70后乃至80后已成中坚、追求实实在在的效益、这里的人们也有不少不为人知的烦恼……这些词是几天前我访问药源药物化学(上海)有限公司技术总监何训贵博士后